Heritability of catastrophizing

Fillingim, Roger B.

doi:10.1097/01.j.pain.0000460338.16353.8e

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…It involves the interaction of multiple factors, and bidirectional relations between biological, psychological and social factors. 51 The reversed models in this study confirm this assumption. One of the reversed models (Model 2, Table 9) showed a relatively stronger, mediating effect of pain intensity on catastrophizing thoughts among women with low education than the hypothesized model (Table 8), where catastrophizing thoughts were mediator.…”

Section: Discussionsupporting

confidence: 75%

<p>Mediators of Pain and Physical Function in Female and Male Patients with Chronic Pain</p>

Danielsson¹,

Kvarstein²,

Bergvik³

2020

JPR

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Purpose: Chronic pain is often multifactorial and accompanied by psychological distress, catastrophizing thoughts, reduced physical function, and socioeconomic worries. In this explorative study, we investigated potential mediators in the relationships of psychological and demographic variables with chronic pain and physical function in women and men. Patients and Methods: The study included 301 patients admitted to a multidisciplinary pain clinic. Prior to their first consultation, patients completed a questionnaire including items on demographics (age, education, occupational and financial situation), catastrophizing thoughts, psychological distress, pain intensity, and physical function. Hierarchical multiple regression analyses examined demographic and psychological factors associated with pain intensity and physical function. Mediation and reversed mediation models were tested and developed based on calculated relations in the regression analyses between demographic, psychological, pain intensity and physical function variables. Results: Fifty-eight percent were females and mean age 43.8 and 46.0 years for women and men, respectively. In the regression analyses, psychological factors accounted better for pain intensity than demographic variables, while physical function was best accounted for by demographic variables. Among women, catastrophizing thoughts mediated significantly the relationships between education and pain intensity, and between education and physical function. Psychological distress mediated significantly the relationships between financial situation and pain intensity, and between financial situation and physical function in women. In men, the only significant mediation model was psychological distress mediating the relationship between financial situation and pain intensity. Some of the reversed models revealed indirect effects, indicating bidirectionality. Conclusion: The results indicate that there might be gender-specific mediators in how demographic variables are associated with pain intensity and physical function. This suggests an awareness among clinicians of potential gender-specific factors mediating pain problems, and the need for a gender-specific, multidisciplinary approach in the treatment of chronic pain.

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Section: Discussionsupporting

confidence: 75%

<p>Mediators of Pain and Physical Function in Female and Male Patients with Chronic Pain</p>

Danielsson¹,

Kvarstein²,

Bergvik³

2020

JPR

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“…Thus, the genetic risk for some psychological components of the pain experience may be distinct from the genetic risk for sensory components of the pain experience (ie, laboratory pain sensitivity). 44 In a study of genetic risk for temporomandibular disorder (TMD) onset, prostaglandin-endoperoxide synthase 1 (PTGS1, rs3842803) was associated with global psychological symptoms, and amyloid-β (A4) precursor protein (APP, rs466448) was associated with stress and negative affectivity, 130 indicating that more global psychological factors predictive of chronic pain development are influenced by genetic factors. In addition to pain, offspring of parents with chronic pain are more likely to experience externalizing and internalizing problems.…”

Section: Potential Mechanisms For the Transmission Of Riskmentioning

confidence: 99%

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

Stone

Wilson

2016

Pain

125

135

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Offspring of parents with chronic pain are at increased risk for pain and adverse mental and physical health outcomes (Higgins et al, 2015). Although the association between chronic pain in parents and offspring has been established, few studies have addressed why or how this relation occurs. Identifying mechanisms for the transmission of risk that leads to the development of chronic pain in offspring is important for developing preventive interventions targeted to decrease risk for chronic pain and related outcomes (eg, disability and internalizing symptoms). This review presents a conceptual model for the intergenerational transmission of chronic pain from parents to offspring with the goal of setting an agenda for future research and the development of preventive interventions. Our proposed model highlights 5 potential mechanisms for the relation between parental chronic pain and pediatric chronic pain and related adverse outcomes: (1) genetics, (2) alterations in early neurobiological development, (3) pain-specific social learning, (4), general parenting and family health, and (5) exposure to stressful environment. In addition, the model presents 3 potential moderators for the relation between parent and child chronic pain: (1) the presence of chronic pain in a second parent, (2) timing, course, and location of parental chronic pain, and (3) offspring’s characteristics (ie, sex, developmental stage, race or ethnicity, and temperament). Such a framework highlights chronic pain as inherently familial and intergenerational, opening up avenues for new models of intervention and prevention that can be family centered and include at-risk children.

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“…This finding was mostly attributable to challenge appraisals and non‐reactivity. Somewhat unexpectedly, despite the wealth of research suggesting that pain catastrophizing is a robust predictor of pain outcomes (Day & Thorn, 2010; Drahovzal et al, 2006; Edwards et al, 2011; Fillingim, 2015, 2017; Flor et al, 1993; Geisser et al, 1994; Keefe et al, 2004; Martinez‐Calderon et al, 2019; Quartana et al, 2009; Sullivan, Thorn, et al, 2001) and is a potential mediator of sex/race differences (Chibnall et al, 2005; Edwards et al, 2005; Fabian et al, 2011; Pence‐Forsythe et al, 2011), in the current multivariate analyses, catastrophizing did not emerge as the strongest cognitive factor. Given the network of associations that was found, and that sex differences—but not race differences—were found for pain tolerance and for both challenge appraisals and non‐reactivity, these cognitive variables were identified as potential prime candidate mediators of sex differences in pain.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most common secondary appraisals in response to pain is pain catastrophizing . Research has shown that pain catastrophizing often (but not always) predicts worse pain‐related outcomes (Day & Thorn, 2010; Drahovzal, Stewart, & Sullivan, 2006; Edwards, Cahalan, Mensing, Smith, & Haythornthwaite, 2011; Fillingim, 2015, 2017; Flor, Behle, & Birbaumer, 1993; Geisser, Robinson, Keefe, & Weiner, 1994; Keefe, Rumble, Scipio, Giordano, & Perri, 2004; Martinez‐Calderon, Jensen, Morales‐Asencio, & Luque‐Suarez, 2019; Quartana, Campbell, & Edwards, 2009; Sullivan, Rodgers, & Kirsch, 2001; Sullivan, Thorn, et al, 2001). The finding that both females and minorities report higher pain catastrophizing has been well replicated (Fabian, McGuire, Goodin, & Edwards, 2011; Leung, 2012), with pain catastrophizing potentially accounting for sex/race differences in pain (Chibnall, Tait, Andreson, & Hadler, 2005; Edwards, Moric, Husfeldt, Buvanendran, & Ivankovich, 2005; Fabian et al, 2011; Pence‐Forsythe et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The roles of race, sex and cognitions in response to experimental pain

Day

Ward

Grover

et al. 2020

European Journal of Pain

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Background This study reports a multivariate test of sex and race differences in experimental pain, and the degree to which these differences could be uniquely attributable to three levels of cognition: primary appraisals (threat, challenge), secondary appraisals (pain catastrophizing) and/or cognitive processes (mindful observing, non‐reactivity). Both the predictive and mediator role of the cognitive variables was of interest. Methods The study employed a cross‐sectional experimental design, with the cold pressor task employed as the pain stimulus. The total sample included N = 355 healthy adults (67% female, 33% male; 70% Caucasian, 30% Asian). Results Significant sex and race differences on pain tolerance were found, with females and racial minorities reporting less pain tolerance (ps < 0.001). Males reported significantly higher challenge appraisals and non‐reactivity, and lower pain catastrophizing than females; Asians reported significantly higher threat appraisals and pain catastrophizing than Caucasians. In multivariate analyses, challenge appraisals and non‐reactivity emerged as the strongest predictors of pain tolerance. Furthermore, challenge appraisals mediated the sex‐pain tolerance association (p = .017). Conclusions This study showed that race and sex differences, at least in part, may be accounted for by differences in pain‐related cognitions. Significance The three levels of cognition investigated in this research represent changeable, important processes for potentially mitigating the impact of pain in vulnerable groups.

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Heritability of catastrophizing

Cited by 3 publications

References 16 publications

<p>Mediators of Pain and Physical Function in Female and Male Patients with Chronic Pain</p>

<p>Mediators of Pain and Physical Function in Female and Male Patients with Chronic Pain</p>

Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model

The roles of race, sex and cognitions in response to experimental pain

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