Heritability of central blood pressure and arterial stiffness

Tárnoki, Ádám Domonkos; Tárnoki, Dávid László; Stazi, Maria Antonietta; Medda, Emanuela; Cotichini, Rodolfo; Nisticò, Lorenza; Fagnani, Corrado; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Fanelli, Fabrizio; Baracchini, Claudio; Meneghetti, Giorgio; Osztovits, Janos; Jermendy, György; Préda, István; Kiss, Róbert Gábor; Métneki, Júlia; Horváth, Tamás; Karlinger, Kinga; Rácz, Anita; Lannert, Agnes; Molnár, Andrea; Littvay, Levente; Garami, Zsolt; Bérczi, Viktor; Schillaci, Giuseppe

doi:10.1097/hjh.0b013e32835527ae

Cited by 52 publications

(47 citation statements)

References 59 publications

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“…Variations in SBP and DBP were primarily explained by additive genetic factors, accounting for 61% and 58% of their total variances, with residual variances explained by unique environmental factors, which was consistent with previous studies (Jermendy et al, 2011;Wu et al, 2011). Although low-modest heritability has been estimated in many different ethnic populations (Bochud et al, 2005;DeStefano et al, 2004;Tarnoki et al, 2012), our heritability estimate of PP (0.42) is close to a recent study reported by Tarnoki et al (2013) in Italian, Hungarian, and American twins, reflecting that maybe the heritability of PP does not vary considerably by race. Second, there were significant pair-wise phenotypic correlations among PP, SBP, DBP, and BMI.…”

Section: Discussionsupporting

confidence: 89%

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Zhang

Pang

et al. 2014

Twin Res Hum Genet

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Systolic and diastolic blood pressure, pulse pressure (PP), and body mass index (BMI) are heritable traits in human metabolic health but their common genetic and environmental backgrounds are not well investigated. The aim of this article was to explore the phenotypic and genetic associations among PP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. The studied sample contained 615 twin pairs (17-84 years) collected in the Qingdao municipality. Univariate and multivariate structural equation models were fitted for assessing the genetic and environmental contributions. The AE model combining additive genetic (A) and unique environmental (E) factors produced the best fit for each four phenotypes. Heritability estimated in univariate analysis ranged from 0.42 to 0.74 with the highest for BMI (95% CI 0.70-0.78), and the lowest for PP (95% CI 0.34-0.49). The multivariate model estimated (1) high genetic correlations for DBP with SBP (0.87), PP with SBP (0.75); (2) low-moderate genetic correlations between PP and DBP (0.32), each BP component and BMI (0.24-0.37); (3) moderate unique environmental correlation for PP with SBP (0.68) and SBP with DBP (0.63); (4) there was no significant unique environmental correlation between PP and BMI. Overall, our multivariate analyses revealed common genetic and environmental backgrounds for PP, BP, and BMI in Chinese twins.

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Section: Discussionsupporting

confidence: 89%

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Zhang

Pang

et al. 2014

Twin Res Hum Genet

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“…Our study provided evidence that genetic factors did not substantially contribute to this phenomenon, however, diverse environmental factors (eg, lifestyle: cigarette smoking, nutrition, lack of physical exercises) had a tremendous influence (70%). Our study is in accordance with previous findings that parenchymal thickness was a good marker of atherosclerotic renal disease, considering that atherosclerotic phenotypes were also mainly influenced by environmental factors (23)(24)(25)(26)(27). On the basis of such results, we believe that RPT should be monitored as an important risk factor in individuals with an unhealthy lifestyle.…”

Section: Discussionsupporting

confidence: 92%

Genetic and environmental variance of renal parenchymal thickness: a twin study

Tárnoki

Littvay³

et al. 2013

Croat Med J

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Aim To estimate heritability and environmental effects on renal parenchymal thickness. Methods In this twin study, renal parenchymal thickness of 98 Hungarian healthy adult twin pairs (68 monozygotic, 30 dizygotic) without kidney disease was measured bilaterally using renal ultrasound with Esaote MyLab 70X ultrasound machine with low-frequency curved transducers (1-8 MHz). Results In both monozygotic and dizygotic group there were more women (76.5%). Mean right and left renal parenchymal thickness was 1.32ƒ?%¶+ƒ?%0.33 cm and 1.62ƒ?%¶+ƒ?%0.31 cm, respectively. Age- and sex-adjusted heritability of renal parenchymal thickness was 0.0% (95% confidence interval, 0.0 to 50.2%), shared and unshared environmental factor was 30.2% (4.1 to 55.9%) and 69.8% (45.8 to 89.5%), respectively. Conclusion This study shows a negligible role of heritability and an important role of environmental effects in developing renal parenchymal thickness, emphasizing the importance of lifestyle for primary prevention.

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“…73,74 In a study of 1480 individuals belonging to 817 nuclei of the Framingham Study Offspring Cohort, Mitchell et al 75 demonstrated that the heritability of PWV was 40%. In another study involving pairs of dizygotic and monozygotic twins living in Hungary and the United States, Tarnoki et al 76 observed 51%, adjusted for age, gender and country of origin. A study of 930 individuals in the family of the Erasmus Rucphen Family Study (SayedTabatabaei et al 77 ) found that the heritability of PWV was 26%, adjusted for several risk factors (gender, age, mean arterial pressure, LDL-c , heart rate, and fasting glycemia).…”

Section: Genetic Aspects Of Arterial Stiffness Heritability Of Arterimentioning

confidence: 96%

Arterial Stiffness: Pathophysiological and Genetic Aspects

Alvim

Santos

Bortolotto

et al. 2017

International Journal of Cardiovascular Sciences

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Cardiovascular diseases (CVD) are the main cause of mortality and it represents a significant percentage of hospitalizations. In the scenario of minimization of costs of the health system, methods that identify subclinical CVD would be important. Some guidelines include the measures of aortic stiffness and intima-media thickness of the carotid artery as methods to identify subclinical CVD in hypertensive patients. The pulse wave velocity (PWV) is the gold standard for the evaluation of arterial stiffness. In this review, we report the pathophysiology, the determinants of arterial stiffness, and justify its inclusion in the assessment of hypertensive patient due its direct association with cardiovascular risk, as show in the I Diretriz Brasileira de Prevenção Cardiovascular. In addition, we raised the main genetic studies of this phenotype, due to its complexity, can be modulated by dozens of genes. However, a better understanding of the relationship genetic-arterial stiffness and, even an intervention based on genotypes, should be achieved in future studies.

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Heritability of central blood pressure and arterial stiffness

Abstract: Central systolic and PPs, brachial PP, AIx, aortic PWV are moderately heritable. A moderate genetic covariance among aortic PWV and central PP, central SBP and brachial SBP was found.

Cited by 52 publications

References 59 publications

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Genetic and environmental variance of renal parenchymal thickness: a twin study

Arterial Stiffness: Pathophysiological and Genetic Aspects

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