Heritability of heart rate recovery and vagal rebound after exercise

Nederend, Ineke; Schutte, Nienke; Bartels, Meike; Harkel, Arend D J Ten; Geus, Eco J. C. de

doi:10.1007/s00421-016-3459-y

Cited by 22 publications

(15 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dynamic HR response to exercise may have a genetic basis. Moderate heritability (32–34%) has been demonstrated for exercise and recovery HR during sub-maximal treadmill test [ 43 , 44 ], while a more recent tween study found higher heritability (65%) for HR recovery after one minute from exhaustion in healthy adolescents [ 18 ]. Recent studies have characterized the genetic contribution to resting HR [ 45 ] and HR variability [ 46 ] and their interaction with mortality, but direct link between HR response to exercise and specific genes has not yet been found.…”

Section: Discussionmentioning

confidence: 99%

Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort

et al. 2017

View full text Add to dashboard Cite

BackgroundThe heart rate (HR) response to exercise provides useful information about the autonomic function and has prognostic value, but its reproducibility over a long period of time, a critical requirement for using it as a clinical biomarker, is undetermined.AimTo determine the intra-individual reproducibility of HR dynamics during sub-maximum exercise and one minute recovery.Methods1187 individuals from the Cardio physical fitness assessment test of the UK Biobank repeated a standard exercise stress test twice (recall time 34.2 ± 2.8 months) and were prospectively studied.Results821 individuals complied with inclusion criteria for reproducibility analysis, including peak workload differences between assessments ≤10 W. Intra-individual correlation between HR profile during the first and the second assessment was very high and higher than inter-individual correlation (0.92±0.08 vs 0.87±0.11, p<0.01). Intra-individual correlation of indices describing HR dynamics was: ρ = 0.81 for maximum HR during exercise; ρ = 0.71 for minimum HR during recovery; ρ = 0.70 for HR changes during both exercise and recovery; Intra-individual correlation was higher for these indices of HR dynamics than for resting HR (ρ = 0.64). Bland-Altman plots demonstrated good agreement between HR indices estimated during the first and second assessment. A small but consistent bias was registered for all repeated measurements. The intra-individual consistency of abnormal values was about 60–70%.ConclusionsThe HR dynamics during exercise and recovery are reproducible over a period of 3 years, with moderate to strong intra-individual reproducibility of abnormal values.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Similar to reactivity, recovery plays a crucial role regarding the adaptability of the organism, to face an event and then return to resting level ( Stanley et al, 2013 ). Vagal recovery has also been termed “vagal rebound” in the literature ( Nederend et al, 2016 ). Following our metaphor, recovery deals with whether individuals fill their tank quickly enough to face another stressor, in order to have enough ability to self-regulate and react effectively.…”

Section: Cardiac Vagal Control: a Physiological Indicator Of Self-regmentioning

confidence: 99%

Vagal Tank Theory: The Three Rs of Cardiac Vagal Control Functioning – Resting, Reactivity, and Recovery

2018

View full text Add to dashboard Cite

The aim of this paper is to set the stage for the vagal tank theory, showcasing a functional resource account for self-regulation. The vagal tank theory, building on neurophysiological, cognitive and social psychology approaches, will introduce a physiological indicator for self-regulation that has mainly been ignored from cognitive and social psychology, cardiac vagal control (also referred to as cardiac vagal activity). Cardiac vagal control reflects the contribution of the vagus nerve, the main nerve of the parasympathetic nervous system, to cardiac regulation. We propose cardiac vagal control to be an indicator of how efficiently self-regulatory resources are mobilized and used. Three systematic levels of cardiac vagal control analysis are suggested: resting, reactivity, and recovery. Based on this physiological indicator we derive the metaphor of the vagal tank, which can get depleted and replenished. Overall, the vagal tank theory will enable to integrate previous findings from different disciplines and to stimulate new research questions, predictions, and designs regarding self-regulation.

show abstract

“…The median age at the EST without AAD was 36 years (IQR, 19-47). Sixty-eight patients (36%) were symptomatic before diagnosis: 52 patients (76%) had an arrhythmic syncope and 16 patients (24%) an ACA as their worst symptom before diagnosis (median age at worst symptom, 14 years [IQR, [11][12][13][14][15][16][17][18][19][20]). Symptomatic patients were more often the familial proband (49% versus 8%; P<0.001) and were younger at the EST (23…”

Section: Study Populationmentioning

confidence: 99%

Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Lieve¹,

Dusi

Werf³

et al. 2020

Circ: Arrhythmia and Electrophysiology

View full text Add to dashboard Cite

BACKGROUND: Risk stratification in catecholaminergic polymorphic ventricular tachycardia remains ill defined. Heart rate recovery (HRR) immediately after exercise is regulated by autonomic reflexes, particularly vagal tone, and may be associated with symptoms and ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Our objective was to evaluate whether HRR after maximal exercise on the exercise stress test (EST) is associated with symptoms and ventricular arrhythmias. METHODS: In this retrospective observational study, we included patients ≤65 years of age with an EST without antiarrhythmic drugs who attained at least 80% of their age-and sex-predicted maximal HR. HRR in the recovery phase was calculated as the difference in heart rate (HR) at maximal exercise and at 1 minute in the recovery phase (ΔHRR1′). RESULTS: We included 187 patients (median age, 36 years; 68 [36%] symptomatic before diagnosis). Pre-EST HR and maximal HR were equal among symptomatic and asymptomatic patients. Patients who were symptomatic before diagnosis had a greater ΔHRR1′ after maximal exercise (43 [interquartile range, 25-58] versus 25 [interquartile range, 19-34] beats/min; P<0.001). Corrected for age, sex, and relatedness, patients in the upper tertile for ΔHRR1′ had an odds ratio of 3.4 (95% CI, 1.6-7.4) of being symptomatic before diagnosis (P<0.001). In addition, ΔHRR1′ was higher in patients with complex ventricular arrhythmias at EST off antiarrhythmic drugs (33 [interquartile range, 22-48] versus 27 [interquartile range, 20-36] beats/min; P=0.01). After diagnosis, patients with a ΔHRR1′ in the upper tertile of its distribution had significantly more arrhythmic events as compared with patients in the other tertiles (P=0.045). CONCLUSIONS: Catecholaminergic polymorphic ventricular tachycardia patients with a larger HRR following exercise are more likely to be symptomatic and have complex ventricular arrhythmias during the first EST off antiarrhythmic drug. VISUAL OVERVIEW: A visual overview is available for this article.

show abstract

Heritability of heart rate recovery and vagal rebound after exercise

Cited by 22 publications

References 60 publications

Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort

Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort

Vagal Tank Theory: The Three Rs of Cardiac Vagal Control Functioning – Resting, Reactivity, and Recovery

Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Contact Info

Product

Resources

About