Heritability of Hypocalcemia at First Parturition in Norwegian Cattle: Genetic Correlations with Yield and Weight

Tveit, Borghild; Svendsen, Mathias Tiedemann; Hove, Knut

doi:10.3168/jds.s0022-0302(91)78548-2

Cited by 20 publications

(23 citation statements)

References 18 publications

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“…The 95% HPDR did not include 0 ( Table 2) for mixed inheritance (polygene + major gene) heritability. Karacaören et al (2006) found 340 B. Karacaören et al Tveit et al (1991) or 0.64 by Svendsen et al (1994), agreed with our results. In general, there are no literature estimates on mixture inheritance model heritabilities for MY, DMI, and BW in dairy cattle, and hence our results cannot compared; while for MS the mixed heritabilities were reported to be higher than polygenic heritabilities (Ilahi and Kadarmideen 2004).…”

Section: Point Estimates Of Mixed Inheritance Model Heritabilitiessupporting

confidence: 83%

Investigation of major gene for milk yield, milking speed, dry matter intake, and body weight in dairy cattle

2006

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The main aim of this study was to determine if there exist any major gene for milk yield (MY), milking speed (MS), dry matter intake (DMI), and body weight (BW) recorded at various stages of lactation in first-lactation dairy cows (2543 observations from 320 cows) kept at the research farm of the Swiss Federal Institute of Technology between April 1994 and April 2004. Data were modelled based a simple repeatability covariance structure and analysed by using Bayesian segregation analyses. Gibbs sampling was used to make statistical inferences on posterior distributions; inferences were based on a single run of the Markov chain for each trait with 500,000 samples, with each 10th sample collected because of the high correlation among the samples. The posterior mean (+/-SD) of major gene variance was 2.61 (+/-2.46) for MY, 0.83 (+/-1.26) for MS, 4.37 (+/-2.34) for DMI, and 2056.43 (+/-665.67) for BW. Highest posterior density regions for 3 of the 4 traits did not include 0 (except MS), which supported the evidence for major gene. With additional tests for agreement with Mendelian transmission probabilities, we could only confirm the existence of a major gene for MY, but not for MS, DMI, and BW. Expected Mendelian transmission probabilities and their model fits were also compared.

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Section: Point Estimates Of Mixed Inheritance Model Heritabilitiessupporting

confidence: 83%

Investigation of major gene for milk yield, milking speed, dry matter intake, and body weight in dairy cattle

2006

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“…Heritability estimates for serum Ca concentration in Holsteins after calving are lacking. Only one study investigated the genetic variation of Ca concentration in Norwegian Reds cows and reported a low heritability (0.11 ± 0.09) that was not statistically different from zero (Tveit et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Serum Ca, P, Mg, and K concentrations are influenced by environmental factors, mainly nutrition (NRC, 2001;Kronqvist, 2011). Nutritional and management strategies for the prevention of these macromineral deficiencies have been developed (Bethard et al, 1998;Tauriainen et al, 2003;Rérat et al, 2009); however, a genetic component to these traits also exists, as reported for serum Ca concentration by Tveit et al (1991).…”

Section: Introductionmentioning

confidence: 99%

“…Genetic studies so far have focused on heritability estimates of clinical hypocalcemia (milk fever) (Dyrendahl et al, 1972;Lin et al, 1989;Abdel-Azim et al, 2005) and genetic and phenotypic correlations between milk fever and various disease (Lin et al, 1989) and production traits (Lyons et al, 1991;Uribe et al, 1995;Heringstad et al, 2005). Tveit et al (1991) reported heritability estimates for postpartum serum Ca concentrations in first-lactation Norwegian cows. However, genetic studies of serum Ca, P, Mg, and K concentrations in fresh Holstein dairy cows are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Genetic parameters of calcium, phosphorus, magnesium, and potassium serum concentrations during the first 8 days after calving in Holstein cows

Tsiamadis

Banos

Panousis

et al. 2016

Journal of Dairy Science

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Calcium, Mg, P, and K are of great importance for the health and productivity of dairy cows after calving. So far genetic studies have focused on clinical hypocalcemia, leaving the genetic parameters of these macroelements unstudied. Our objective was to estimate the genetic parameters of Ca, Mg, P, and K serum concentrations and their changes during the first 8d after calving. The study was conducted in 9 herds located in northern Greece, with 1,021 Holstein cows enrolled from November 2010 until November 2012. No herd used any kind of preventive measures for hypocalcemia. Pedigree information for all cows was available. A total of 35 cows were diagnosed and treated for periparturient paresis and, therefore, excluded from the study. The remaining 986 cows were included in genetic analysis. The distribution of cows across parities was 459 (parity 1), 234 (parity 2), 158 (parity 3), and 135 (parity ≥4). A sample of blood was taken from each cow on d1, 2, 4, and 8 after calving and serum concentrations of Ca, P, Mg, and K were measured in each sample. A final data set of 15,390 biochemical records was created consisting of 3,903 Ca, 3,902 P, 3,903Mg, and 3,682K measurements. Moreover, changes of these concentrations between d1 and 4 as well as 1 and 8 after calving were calculated and treated as different traits. Random regression models were used to analyze the data. Results showed that daily heritabilities of Ca, P, and Mg concentrations traits were moderate to high (0.20-0.43), whereas those of K were low to moderate (0.12-0.23). Regarding concentration changes, only Mg change between d1 and 8 after calving had a significant heritability of 0.18. Genetic correlations between Ca, P, Mg, and K concentrations and their concentration changes from d1 to 4 and 1 to 8 after calving were not significantly different from zero. Most phenotypic correlations among Ca, P, Mg, and K concentrations were positive and low (0.09-0.16), whereas the correlation between P and Mg was negative and low (-0.16). Phenotypic correlations among macromineral concentrations on d1 and their changes from d1 to 4 and 1 to 8 after calving varied for each macromineral. This study revealed that genetic selection for normal Ca, P, Mg, and K concentrations in the first week of lactation is possible and could facilitate the management of their deficiencies during the early stages of lactation.

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“…The hypocalcemia occurs because Ca leaves the extracellular fluid pool to enter the mammary gland faster than it can be replaced by intestinal Ca absorption or bone Ca resorption (Goings et al, 1974;Jorgensen, 1974;Goff and Horst, 1997). Low blood calcium can be explained by increasing cortisone and estrogen levels in blood and decreasing receptor number of D vitamin in intestine during parturition (Horst et al, 1989;Tveit et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Effects of calcium propionate by different numbers of applications in first week postpartum of dairy cows on hypocalcemia, milk production and reproductive disorders

Kara

Orman

Udum

et al. 2009

Italian Journal of Animal Science

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This study was conducted to evaluate effects of calcium propionate on hypocalcemia, dry matter intake, body condition score, milk production and reproductive disorders in dairy cows. Twenty four multiparous Holstein cows were sorted by parity, body condition score (BCS) in close-up period and season of calving and assigned to one of the three treatments. The cows in treatment 1 (T1) received two drenches at calving and 24h after calving. The cows in treatment 2 (T2) received three drenches at calving, 24h after calving and 7 days after calving. The cows in treatment 3 (T3) were the control. Each drench contained 143g of calcium as calcium propionate (0.68kg). Parameters studied were serum calcium, glucose and nonesterified fatty acid (NEFA) concentrations, dry matter intake (DMI), BCS, milk production (MP), incidence of retained placenta (RP) and metritis. Milk fever developed in 5 of 8 cows, in 3 of 8 cows and in 3 of 8 cows in T1, T2 and T3, respectively, at calving. There was no cow with milk fever in T1 and T2 at 4h after second drench (about 28h after calving) but 3 of 8 cows in T3 had still milk fever at this time. The cows receiving two drenches recovered from milk fever in a shorter term as compared to the cows in T3. There were no differences among treatments for DMI, BCS, MP, RP, serum glucose and NEFA concentrations during the experimental period. There was no difference for metritis between T1 and T3 but incidence of metritis in T2 was significantly lower as compared to T3 (P<0.05). Two drenches of calcium propionate were beneficial in treating milk fever and three drenches of calcium propionate were considered to have had a preventive effect for metritis

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Heritability of Hypocalcemia at First Parturition in Norwegian Cattle: Genetic Correlations with Yield and Weight

Cited by 20 publications

References 18 publications

Investigation of major gene for milk yield, milking speed, dry matter intake, and body weight in dairy cattle

Investigation of major gene for milk yield, milking speed, dry matter intake, and body weight in dairy cattle

Genetic parameters of calcium, phosphorus, magnesium, and potassium serum concentrations during the first 8 days after calving in Holstein cows

Effects of calcium propionate by different numbers of applications in first week postpartum of dairy cows on hypocalcemia, milk production and reproductive disorders

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