Heritability of Ischemic Stroke in Relation to Age, Vascular Risk Factors, and Subtypes of Incident Stroke in Population-Based Studies

Schulz, Ursula G.; Floßmann, Enrico; Rothwell, Peter M.

doi:10.1161/01.str.0000121646.23955.0f

Cited by 164 publications

(128 citation statements)

References 22 publications

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“…Only patients with CI younger than 70 years were recruited because previous studies revealed that genetic influence on CI is greater in younger patients 27,28) . Our aim was to investigate whether we could replicate this finding in a Chinese sample of relatively young individuals.…”

Section: Background Characteristicsmentioning

confidence: 99%

Variants on Chromosome 9p21 Confer Risks of Noncardioembolic Cerebral Infarction and Carotid Plaque in the Chinese Han Population

Zhang

Maimaiti

et al. 2015

JAT

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Aims:Considering that cerebral infarction (CI) may share a common etiological basis with coronary artery disease (CAD), we evaluated six CAD-related single-nucleotide polymorphisms (SNPs) on 9p21 for investigating the effect of 9p21 on CI or carotid plaque in the Chinese Han population. Methods: Altogether, 528 patients with noncardioembolic CI (375 with carotid plaque and 153 without carotid plaque) and 258 control subjects were genotyped. Six SNPs previously shown to be associated with CAD were sequenced and assessed for association with CI and carotid plaque using odds ratio (OR) and 95% confidence interval (CI) from logistic regression models. Results: The G allele frequencies of rs2383206 (OR 1.472, p 0.021) and rs4977574 (OR 1.519, p 0.013) significantly increased in patients with CI without carotid plaque compared with middleaged patients in the control group. The CI risk was higher among the GG genotype carriers than among GA AA genotype carriers (OR 1.794, 95% CI 1.059 -3.039, p 0.030 for rs2383206; OR 1.866, 95% CI 1.088 -3.201, p 0.023 for rs4977574). In comparison with the non-GG genotype, the GG genotype of rs2383206 and rs4977574 combined had a 1.733-fold greater risk of CI in the middle-aged group. SNPs rs2383206 and rs4977574 were also associated with a risk of carotid plaque among patients with CI aged 65 years (OR 2.329, p 0.018 and OR 1.997, p 0.049, respectively). Moreover, six SNPs were strongly correlated with linkage disequilibrium. Conclusions: Genetic variations of rs2383206 and rs4977574 on 9p21 are potentially associated with CI and carotid plaque in the Chinese Han population. Our results provide further evidence that the 9p21 region represents a major risk locus for cerebrovascular diseases.

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Section: Background Characteristicsmentioning

confidence: 99%

Variants on Chromosome 9p21 Confer Risks of Noncardioembolic Cerebral Infarction and Carotid Plaque in the Chinese Han Population

Zhang

Maimaiti

et al. 2015

JAT

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“…Evidence shows that genetic factors are more important in small-and large-vessel stroke than in cardio-embolic stroke [8,9] . Some intermediate phenotypes also exhibit high heritability, such as carotid intima-medial wall thickness (IMT) and white-matter lesions (WML) [3] .…”

Section: Ischemic Strokementioning

confidence: 99%

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

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Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.

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“…23 Family history of stroke is associated with proband hypertension in community-based and hospital-based populations with ischemic stroke. 24 In a pooled analysis of four populations with either stroke or TIA, family history of stroke was strongly related to history of hypertension in the proband, with an OR of 1.8 (95% CI, 1.3 to 2.5; p = 0.0008). 25 Several authors caution that hypertension may account for a significant component of the heritability of ischemic stroke.…”

Section: Discussionmentioning

confidence: 96%