Heritability of premature mitral valve disease in Cavalier King Charles spaniels

Lewis, Thomas M.; Swift, Simon; Woolliams, John; Blott, Sarah

doi:10.1016/j.tvjl.2010.02.016

Cited by 67 publications

(84 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Olsen et al (1999) have postulated that a polygenic character of inheritance may be responsible for the disease in Dachshunds, while Madsen et al (2011) have implicated two loci in CMVD in the Cavalier King Charles Spaniel (CKCS), another breed affected by the disease. These publications underlie the role genetics play in this acquired disease (Lewis et al 2011). French et al (2012) have shown that the disease is not a result of a single gene effect in the CKCS, emphasizing the necessity to find specific mutations when making decisions related to breeding dogs.…”

Section: Introductionmentioning

confidence: 99%

Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

Garncarz¹,

Hulanicka²,

Maciejewski³

et al. 2016

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

Studies identifying specific pathologically expressed genes have been performed on diseased myocardial tissue samples, however less invasive studies on gene expression of peripheral blood mononucleated cells give promising results. This study assessed transcriptomic data that may be used to evaluate Dachshunds with chronic mitral valve disease. Dachshunds with different stages of heart disease were compared to a control, healthy group. Microarray data analysis revealed clusters of patients with similar expression profiles. The clusters were compared to the clinical classification scheme. Unsupervised classification of the studied groups showed three clusters. Clinical and laboratory parameters of patients from the cluster 1 were in accordance with those found in patients without heart disease. Data obtained from patients from the cluster 3 were typical of advanced heart failure patients. Comparison of the cluster 1 and 3 groups revealed 1133 differentially expressed probes, 7 significantly regulated process pathways and 2 significantly regulated Ariadne Metabolic Pathways. This study may serve as a guideline for directing future research on gene expression in chronic mitral valve disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

Garncarz¹,

Hulanicka²,

Maciejewski³

et al. 2016

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…The cause of MVD is still unknown, although a genetic predisposition is noted in some breeds such as Cavalier King Charles spaniels. Senility is also a predisposing factor, especially in small breed animals (Hyun, 2005;Atkins et al, 2009, Lewis et al, 2011Borgarelli and Buchanan, 2012). There is a higher prevalence in males, which are generally affected at a younger age than females (Borgarelli et al, 2004;Borgarelli and Häggström, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…This regurgitation can be detected during physical examination by auscultation of a left apical systolic murmur (Ljungvall et al, 2009;Lewis et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The disease has a slow progression over the years and in many cases can lead to the appearance of signs of congestive heart failure (CHF) (Abbott, 2008;Borgarelli et al, 2008;Häggström et al, 2009;Lewis et al, 2011). Development of CHF worsens the prognosis, so an early diagnosis should assist in appropriate clinical management (Schober et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Use of discriminant analysis based on echocardiography for classification of congestive heart failure in dogs with myxomatous mitral valve disease

Silva

Muzzi

et al. 2014

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

“…This progression can lead to congestive heart failure (chf) and due to the variable disease pathology can also lead to sudden death. [13,14] The aim of this review is to further understand the latest developments of myxomatous degeneration in order to prevent these complications. 1 This article is the result of a research project of the National Comittee for Research Development (Conadi according to its initials in Spanish) at Universidad Cooperativa de Colombia.…”

Section: Introductionmentioning

confidence: 99%

Myxomatous valve degeneration

et al. 2013

View full text Add to dashboard Cite

Abstract. This review article is an analysis of the most recent published scientific articles about myxomatous valve degeneration (mvd) and was conducted over a five month period. The aim of this review is to consolidate information about the most recent medical developments in regards to myxomatous degeneration in the mitral valve. The authors of this article reached a consensus on both the development of the disease and the most effective type of diagnosis and treatment that is available today. Myxomatous valve degeneration is the most common heart disease in the canine population. It is identified by a loss of mechanical integrity in the heart due to structural changes in the valvular components. Degenerative changes occur due to an accumulation of mucopolysaccharides in the leaflets and chordae which affect the proper operation of the valve apparatus. This is caused by faulty coaptation of the leaflets, resulting in mitral or tricuspid regurgitation, dilated ventricles and annuli, which are lesions that eventually cause the rupture of the chordae tendineae, leading to complications or possibly death. Due to the gradual progression of the disease and the presence or absence of clinical signs, it is very important that veterinarians accurately diagnose and follow-up on these patients in order to achieve stabilization and provide a suitable prognosis and treatment plan. The current ideal treatment of the disease is a low-sodium diet, administration of the ace inhibitor (angiotensin-converting-enzyme inhibitor) spironolactone and a diuretic in order to reduce the presence of pulmonary edema and avoid the progression of the disease to congestive heart failure.Keywords: av valves, canine, heart, Myxomatous degeneration, treatment. Degeneração valvar mixomatosa. Um olhar nos últimos avanços em todos os aspectos da doençaResumo. Este artigo de revisão se realizou durante um período de cinco meses. Incluíram-se, neste, os últimos avanços publicados em artigos científicos. Conseguiu-se realizar um consenso quanto ao desenvolvimento da doença, ao tipo de diagnóstico mais adequado e ao tratamento que melhores resultados está mostrando na atualidade. O objetivo desta revisão foi conhecer as últimas atualizações sobre a degeneração valvular mixomatosa. A degeneração valvar mixomatosa é a doença cardíaca mais comum na população canina, na qual há uma perda da integridade mecânica devido a mudanças estruturais nos componentes valvulares. As mudanças se devem a uma acumulação de mucopolisacáridos nas cordas tendíneas e nas valvas as quais iniciam com falhas na coaptação das valvas gerando uma regurgitação mitral ou tricuspidiana, dilatação dos ventrículos e do anel valvular, levando a complicações ou morte do paciente. Devido ao progresso gradual das lesões na doença e à manifestação ou não de signos clínicos, o diagnóstico exato e seguimento apropriado desses pacientes é de grande importância para os médicos veterinários com o objetivo de prognosticar e instaurar o tratamento adequado. O melhor tratamento na atualidade para...

show abstract

Heritability of premature mitral valve disease in Cavalier King Charles spaniels

Cited by 67 publications

References 14 publications

Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

Correlation between peripheral blood cell transcriptomic profile and clinical parameters of chronic mitral valve disease in Dachshunds

Use of discriminant analysis based on echocardiography for classification of congestive heart failure in dogs with myxomatous mitral valve disease

Myxomatous valve degeneration

Contact Info

Product

Resources

About