Heritability of running economy: a study made on twin brothers

Rodas, Gil; Calvo, Mar; Estruch, Asunción; Garrido, Eduardo; Ercilla, Guadalupe; Arcas, Antoni; Segura, Ramón; Ventura, Josep L.

doi:10.1007/s004210050368

Cited by 17 publications

(13 citation statements)

References 38 publications

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“…Only one study has investigated the heritability of running economy at running speed of 5, 6, 7 and 8 km?h 21 by using the monozygotic and dizygotic twin method in an untrained state, but the researchers did not detect any genetic component in running economy (nor in VO 2 max relative to Table 2 Running economy at baseline and response to training according to HBB genotype body mass). 34 The heritability of VO 2 max, on the other hand, has been well documented in previous research. 20 35 Therefore, it was postulated that the report of Rodas et al was questionable due, possibly, to the limited sample size.…”

Section: Discussionmentioning

confidence: 63%

“…20 35 Therefore, it was postulated that the report of Rodas et al was questionable due, possibly, to the limited sample size. 34 Moreover, these alleles might contribute to the trainability of running economy but do not appear to influence running economy in the untrained state. The HBB gene would be a new gene associated with the training response of running economy.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms in theHBBgene relate to individual cardiorespiratory adaptation in response to endurance training

Hu²,

Feng³

et al. 2006

Br J Sports Med

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Objective: The crucial role of haemoglobin in endurance performance has been well documented. We examined whether polymorphisms in the HBB gene modified aerobic capacity. Methods: 102 recruits were trained by running 5000 m three times per week for 18 weeks. Exercise intensity progressively increased from an initial heart rate corresponding to 95% of the individual baseline ventilatory threshold during the first 10 weeks to 105% during the last 8 weeks. The phenotypes measured were running economy and VO 2 max. Running economy was determined by measuring submaximal VO 2 for 5 min at a constant running speed of 12 km?h 21 and VO 2 max was obtained during an incremental test to exhaustion. Genomic DNA was extracted from white cells of peripheral blood and the 2551C/T, intron2,+16C/G and +340 A/T genotypes were examined relative to the TAA site variants by PCR-RFLP. Results: Genotype distributions were in Hardy-Weinberg equilibrium at three loci. None of the running economy and VO 2 max-related traits were associated with the three polymorphisms or haplotypes at baseline, while the training response of running economy was associated with 2551C/T and intron2,+16C/G polymorphisms. Subjects homozygous for intron2,+16C/C or 2551C/C had decreased oxygen cost of running compared to the other individuals. Discussion: It was concluded that the 2551C/C or intron2,+16C/C genotype might explain part of the individual variation in the cardiorespiratory adaptation to endurance training.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Polymorphisms in theHBBgene relate to individual cardiorespiratory adaptation in response to endurance training

Hu²,

Feng³

et al. 2006

Br J Sports Med

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“…The residual variance of each of the previous ANOVA was the estimate of variability for the gene type considered and, therefore, (Rodas et al 1998). Using this method we calculated the coecient of the dierence between the residual variance of DZ and MZ with respect to the residual variance of DZ.…”

Section: Discussionmentioning

confidence: 99%

“…In this respect, the genetic component of several physiological variables ± maximal oxygen uptake, running economy, aerobic endurance and anthropometric characteristics ± has been reported to be dierent (Bouchard et al 1992(Bouchard et al , 1999(Bouchard et al , 2000Fagard et al 1991;Hamel et al 1986;Rodas et al 1998). Although aerobic metabolism has been extensively studied and the results of these studies seem conclusive, studies on anaerobic metabolism are not de®nitive (Jones and Klissouras 1985;Komi and Karlsson 1979;Paxinos et al unpublished work presented at the International Federation of Sports Medicine Congress, Amsterdam, 1990).…”

Section: Introductionmentioning

confidence: 97%

Heritability of explosive power and anaerobic capacity in humans

Calvo

Rodas²,

Vallejo

et al. 2001

Eur J Appl Physiol

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There is a disparity in the information about the heritability of the response of muscle anaerobic metabolism to exercise and the use of explosive power, as well as a lack of information concerning the genetic determinants of this form of work, as measured using different specific physical tests. We applied a battery of some of the commonly employed procedures (Ergojump, Wingate, maximal accumulated oxygen deficit, excess post-exercise oxygen consumption, and delta lactate concentration) to a group of 32 Caucasian male twins, 8 monozygotic and 8 dizygotic pairs, who had similar environmental backgrounds. Results were studied using a heritability index (HI). Zygosity was determined using the identity of erythrocyte antigens, protein and enzyme polymorphism and human leucocyte antigen serologic types between co-twins. Significant HI values (P< 0.05) were found in the following tests: maximal 5 s power (HI = 0.74) and total power in a 30 s interval (HI = 0.84) in the Wingate test, maximal lactate concentration (HI = 0.82) and delta lactate concentration (HI = 0.84) in the maximal progressive test, as well as in the 2nd (HI = 0.93) and in the 3rd min (HI = 0.92) of recovery after the deficit test. In this study, the most relevant findings were: firstly, significant HI values for many of the variables studied; secondly, the HI values of the parameters used to evaluate explosive power were higher than those of lactic acid capacity and thirdly, the HI of certain variables from different tests measuring, in theory, similar qualities, were different.

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“…Standard descriptive measures were used (mean and standard deviation). Differences between measures of monozygotic and dizygotic pairs of twins were assessed by the F value, calculated as the dizygotic variance divided by the monozygotic variance (Rodas et al, 1998;Calvo et al, 2002) after the normality assumption was verified with the Shapiro Wilk Test. Associations between variables were investigated with the Pearson Product-Moment coefficient.…”

Section: Statisticsmentioning

confidence: 99%

Evidence for Higher Heritability of Somatotype Compared to Body Mass Index in Female Twins

Reis

Machado

Fortes

et al. 2007

J Physiol Anthropol

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The influence of genetics on human physique and obesity has been addressed by the literature. Evidence for heritability of anthropometric characteristics has been previously described, mainly for the body mass index (BMI). However, few studies have investigated the influence of genetics on the Heath-Carter somatotype. The aim of the present study was to assess the heritability of BMI and somatotype (endomorphy, mesomorphy, and ectomorphy) in a group of female monozygotic and dizygotic twins from childhood to early adulthood. A total of 28 females aged from 7 to 19 years old were studied. The group included 5 monozygotic and 9 dizygotic pairs of twins. The heritability was assessed by the twin method (h 2 ). The anthropometric measures and somatotype were assessed using standard validated procedures. Significant differences between monozygotic and dizygotic pairs of twins were found for height, endomorphy, ectomorphy, and mesomorphy, and the heritability for these measures was high (h 2 between 0.88 and 0.97). No significant differences were found between monozygotic and dizygotic twins for weight, and the BMI and the heritability indexes were lower for these measures (respectively 0.42 and 0.52). The results of the present study have indicated that the somatotype may be more sensible to genetic influences than the BMI in females.

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Heritability of running economy: a study made on twin brothers

Cited by 17 publications

References 38 publications

Polymorphisms in theHBBgene relate to individual cardiorespiratory adaptation in response to endurance training

Polymorphisms in theHBBgene relate to individual cardiorespiratory adaptation in response to endurance training

Heritability of explosive power and anaerobic capacity in humans

Evidence for Higher Heritability of Somatotype Compared to Body Mass Index in Female Twins

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