Heritability of the limbic networks

Budisavljević, Sanja; Kawadler, Jamie M.; Dell’Acqua, Flavio; Rijsdijk, Frühling; Kane, Fergus; Picchioni, Marco; McGuire, Philip; Toulopoulou, Timothea; Georgiades, Anna; Kalidindi, Sridevi; Kravariti, Eugenia; Murray, Robin M.; Murphy, Declan; Craig, Michael C.; Catani, Marco

doi:10.1093/scan/nsv156

Cited by 44 publications

(36 citation statements)

References 125 publications

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“…The low-to-moderate heritability of adolescent anxiety measures in the literature 38 , 40 thus suggests anxiety as a prudent choice for our analyses. In our sample, the ICCs (twin similarity correlations) for the left and right UF FA were 0.67 and 0.75, respectively, which is in agreement with ICC estimates in adult twin studies 56 , 57 . Previous studies have reported that heritability estimates of UF FA increase with age from relatively low in early childhood to quite high in adulthood 56 , 58 .…”

Section: Discussionsupporting

confidence: 88%

“…In our sample, the ICCs (twin similarity correlations) for the left and right UF FA were 0.67 and 0.75, respectively, which is in agreement with ICC estimates in adult twin studies 56 , 57 . Previous studies have reported that heritability estimates of UF FA increase with age from relatively low in early childhood to quite high in adulthood 56 , 58 . In the current study, both samples were selected to ensure at least a portion of the twins were discordant for anxiety.…”

Section: Discussionsupporting

confidence: 88%

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Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach

Adluru

Luo

Hulle

et al. 2017

Sci Rep

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Anxiety is linked to deficits in structural and functional connectivity between limbic structures and pre-frontal cortices. We employed a monozygotic (MZ) twin difference design to examine the relationship between structural characteristics of the uncinate fasciculus (UF) measured by Diffusion Tensor Imaging (DTI) and anxiety symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins. The MZ difference design allowed us focus on environmental factors that vary within twin pairs while controlling for genetic and environmental factors shared by twin pairs. Twins aged 13–18 years reported on symptoms of generalized anxiety and social phobia prior to participating in a neuroimaging visit. Regions of interest from the JHU ICBM atlas, including uncinate fasciculus and sagittal stratum as a control tract, were registered to the study template. We incorporated multiple diffusion tensor measures to characterize the white matter differences. Within twin pairs, the more anxious twin exhibited decreased fractional anisotropy (t = −2.22, p = 0.032) and axial diffusivity (t = −2.38, p = 0.022) in the left UF compared to the less anxious twin, controlling for age and gender. This study demonstrated the feasibility and advantages of adopting the MZ twin design for DTI measures in neuroimaging research.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach

Adluru

Luo

Hulle

et al. 2017

Sci Rep

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“…Even though brain imaging investigations in social neurosciences have mainly focused on cortical grey matter, the major role white matter plays in communication between different brain areas indicates that investigating its association with specific functions can lead to a better understanding of human cognition and behavior [16][17][18] . Indeed, diffusion tensor imaging (DTI) studies have allowed to describe structural white matter correlates of various psychiatric and neurological disorders 19 , as well as an association between anatomical connectivity and individual traitsof social behavior in young healthy adults 18 .…”

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confidence: 99%

Neural basis of interindividual variability in social perception in typically developing children and adolescents using diffusion tensor imaging

Vinçon-Leite

Saitovitch

Lemaître

et al. 2020

Sci Rep

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Humans show great interindividual variability in the degree they engage in social relationship. the neural basis of this variability is still poorly understood, particularly in children. in this study, we aimed to investigate the neural basis of interindividual variability in the first step of social behavior, that is social perception, in typically developing children. For that purpose, we first used eye-tracking to objectively measure eye-gaze processing during passive visualization of social movie clips in 24 children and adolescents (10.5 ± 2.9 y). Secondly, we correlated eye-tracking data with measures of fractional anisotropy, an index of white matter microstructure, obtained using diffusion tensor imaging MRI. The results showed a large interindividual variability in the number of fixations to the eyes of characters during visualization of social scenes. In addition, whole-brain analysis showed a significant positive correlation between FA and number of fixations to the eyes,mainly in the temporal part of the superior longitudinal fasciculi bilaterally, adjacent to the posterior superior temporal cortex. our results indicate the existence of a neural signature associated with the interindividual variability in social perception in children, contributing for better understanding the neural basis of typical and atypical development of a broader social expertise. Human's everyday life is fundamentally social. Whereas social skills are very ubiquitous, the quantitative and the qualitative propensity to engage in social interactions is very heterogeneous, individual and subjective. This variability results in a wide spectrum of social behaviors, that can range from extreme shyness to extreme extroversion 1. Further comprehension of this interindividual variability is crucial to understanding its neural substrates. Over the last decades, brain imaging studies have largely investigated the neural basis of social processes, which allowed to describe a brain network particularly implicated in processing social information: the social brain, composed of the amygdala, the superior temporal sulcus (STS), the orbitofrontal cortex, and fusiform gyrus 2,3. Within this network, the STS is considered a hub for social perception and social cognition, including the perception of eyes, faces and human motion, as well as understanding others' actions and mental states 4. More recently, studies have also started to investigate the anatomo-functional neural correlates of interindividual variability in social functioning. Results from structural MRI studies, for instance, showed a correlation between different degrees of social behavior and gray matter volume in specific brain regions 5-8. Functional MRI (fMRI) activation studies showed different degrees of brain activation in specific regions associated with different levels of social behavior 9-11. Lately, resting state fMRI (rs-fMRI) studies demonstrated that intrinsic brain functional connectivity is associated with interindividual variability in cognitive performances, such ...

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“…6 illustrates that the general cognitive score and psychopathology exhibited independent associations with LICA-09. This WM microstructural pattern is of particular interest with respect to mental health for several reasons: UF is among the tracts with the highest heritability 33 , it displays a protracted maturation pattern as compared to other fiber tracts 8 , and is hypothesized to subserve a limbic temporoamygdala-orbitofrontal network, critically involved in integration of emotional states with cognition and behavior 32,34 . When investigating individual clinical ICA components, each of which express more symptom specificity compared to the general psychopathology score, similar relationships with LICA-09 subject weights ( Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

Alnæs

Kaufmann

Doan

et al. 2017

Preprint

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A healthy transition from adolescence to adulthood relies on a continuous individual adaptation to a dynamic environment. Here, we employed data driven multivariate approaches to derive both general cognitive and psychopathology factors as well as brain phenotypes in children and adolescents in the publicly available PNC sample.We identified a distinct brain white matter pattern which proved central for prediction of heritable cognition and psychopathology scores, highlighting the importance of fronto-temporal connections for intellectual and mental development.

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Heritability of the limbic networks

Cited by 44 publications

References 125 publications

Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach

Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach

Neural basis of interindividual variability in social perception in typically developing children and adolescents using diffusion tensor imaging

Heritable cognitive and psychopathology factors in youth are predicted by brain fronto-temporal white matter pathway

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