Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS)

Zarkesh, Maryam; Daneshpour, Maryam S.; Faam, Bita; Fallah, Mohammad; Hosseinzadeh, Nima; Guity, Kamran; Hosseinpanah, Farhad; Momenan, Amir Abbas; Azizi, Fereidoun

doi:10.1017/s001667231200050x

Cited by 45 publications

(30 citation statements)

References 36 publications

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“…Studies show that MetS has both genetic and environmental bases. In fact in the TLGS population, the highest heritability among MetS components was for HDL-C and TG [27]. Our finding extends our recent findings showing that family history of diabetes might be a surrogate of genetic basis has an independent role for incident MetS.…”

Section: Discussionsupporting

confidence: 84%

Incidence of Metabolic Syndrome over 9 Years Follow-Up; the Importance of Sex Differences in the Role of Insulin Resistance and Other Risk Factors

et al. 2013

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To determine, the predictors of incident metabolic syndrome (MetS) in a community-based cohort of West Asians, during a mean follow-up of 9.3 years, a sample of 2858 non-MetS Iranian adults aged ≥ 20 years were examined at baseline and followed at three year intervals during three consecutive phases. The MetS was defined using the joint interim statement. Cox proportional hazard regression was used to determine the independent variables associated with incident MetS. Overall, 1117 new cases MetS were identified resulting in an incidence rate of 550.9/10000 person years (95% CI: 519.5-584.2). The corresponding incidence rates among women and men were 433.5/10000 person years (95% CI: 398.8-471.2) and 749.2/10000 person years (95% CI: 689.9-813.5), respectively. Baseline-adjusted predictors of developing MetS included all of the MetS components, being overweight or obese in both gender, and family history of diabetes and age only in women. There were significant effect modifications of gender on age (P<0.001), high blood pressure (0.026), high waist circumference (P<0001) and obesity categories (all P ≤ 0.01) in multivariate analysis. After considering HOMA–IR in the model, among women, all of the MetS predictors as well as those with HOMA-IR ≥ 2.23 showed a significant risk for incident MetS [HR: 1.63 (1.16-2.28)]; however, among men all the MetS components (WC was marginally significant) as well as the fourth quartile of HOMA-IR [HR: 1.50 (1.03-2.17)] and being overweight showed a significant risk. Finally, in the pooled analysis, we showed that female gender had lower risk for incident MetS than male [HR: 0.58 (0.47-0.70)]. In the Iranian population, high incidence of MetS, especially among men, was shown. Our findings confirmed that sex- specific risk predictors should be considered in primary prevention for incident MetS.

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Section: Discussionsupporting

confidence: 84%

Incidence of Metabolic Syndrome over 9 Years Follow-Up; the Importance of Sex Differences in the Role of Insulin Resistance and Other Risk Factors

et al. 2013

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“…Lifestyle, diet, lack of physical activities, and genetics are the factors involved in this syndrome (40). It seems that a diet containing pistachio promotes the metabolic profile and decreases the harmful outcomes of metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

The effect of pistachios on human health: A review study

Shahrabadi

Nadimi

Jalalli

et al. 2014

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using the keyword pistachio in combination with cholesterol, cardiovascular, health, consumption, diabetes, serum lipid levels, glucose, and metabolic syndrome. Results: Of the total of 194 articles searched, 19 articles were included in the study. The consumption of pistachio, due to its minerals, vitamins, proteins, and antioxidants, improved health and had a positive impact on health outcomes, such as fat, blood sugar, and weight control. It also helped in the promotion of a healthy heart and recovery of high blood pressure, diabetes, coronary heart disease (CHD), metabolic syndrome, and pre-diabetes. Conclusions: Pistachio, due to its nutrients, has positive impact on human body health, including the cardiovascular system, blood lipids, and blood pressure. Moreover, because of its unsaturated fats, it also affects the lipoproteins and reduces cardiovascular disease (CVD) and diabetes, and helps in the management of weight and metabolic syndrome. It can also help in the recovery of patients with prediabetes through changes in their harmful metabolism. Pistachios are recommended as part of a healthy diet for the human health and prevention of chronic non-infectious diseases.

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“…If closer relatives resemble each other more for metabolic syndrome traits than more distant relatives do, this indicates that familial factors, including genetic factors and familyshared environmental infl uences, are important for these traits. The heritability estimates observed in these studies vary widely, with heritability ranging 24-90% for BMI ( 18,(21)(22)(23)(24), 10-75% for fasting glucose ( 17,20,(22)(23)(24)(25), 20-55% for fasting insulin ( 17,20,22,23,26 ), 0.03-72% for triglycerides ( 17,19,20,(22)(23)(24)(25)27 ), 25-98% for LDLcholesterol ( 17,19,20,22,23,27 ), 30-80% for HDL cholesterol ( 17,19,20,22,24,25,27 ), 30-74% for total cholesterol ( 17,19,20,(22)(23)(24)27 ), 20-71% for SBP ( 14,17,…”

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confidence: 99%