Heritability of Venous Biomechanics

Molnár, Andrea; Tárnoki, Ádám Domonkos; Tárnoki, Dávid László; Kulcsár, Zoltán; Littvay, Levente; Garami, Zsolt; Préda, István; Kiss, Róbert Gábor; Bérczi, Viktor; Lannert, Agnes; Monos, E.; Nádasy, György L.

doi:10.1161/atvbaha.112.300062

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…In an earlier study on monozygotic and dizygotic twins, we separated the inherited, shared environmental and unshared environmental factors in forming the geometric and elastic properties of the common femoral vein [ 19 ]. However, the level of genetic determination of IJV biomechanics has not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

et al. 2018

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AimsThe elasticity of the internal jugular vein (IJV) is a major determinant of cerebral venous drainage and right atrium venous return. However, the level of genetic determination of IJV dimensions, compliance and distensibility has not been studied yet.Methods170 adult Caucasian twins (43 monozygotic [MZ] and 42 dizygotic [DZ] pairs) were involved from the Italian twin registry. Anteroposterior and mediolateral diameters of the IJV were measured bilaterally by ultrasonography. Measurements were made both in the sitting and supine positions, with or without Valsalva maneuver. Univariate quantitative genetic modeling was performed.ResultsGenetic factors are responsible for 30–70% of the measured properties of IJV at higher venous pressure even after adjustment for age and gender. The highest level of inheritance was found in the supine position regarding compliance (62%) and venous diameter during Valsalva (69%). Environmental and measurement-related factors instead are more important in the sitting position, when the venous pressure is low and the venous lumen is almost collapsed. The range of capacity changes between the lowest and highest intraluminal venous pressure (full distension range) are mainly determined by genetic factors (58%).ConclusionsOur study has shown substantial heritability of IJV biomechanics at higher venous pressures even after adjustment for age and gender. These findings yield an important insight to what degree the geometric and elastic properties of the vascular wall are formed by genetic and by environmental factors in humans.

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Section: Introductionmentioning

confidence: 99%

Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

et al. 2018

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“…When we started in 2006, we were already able to publish research in abstract books or in low impact topical medical journals (Jermendy et al, 2011a;2011b;Tarnoki et al, 2007;2010;2011). Today, we are able to publish articles in mid-to-higher-level journals, clearly highlighting the benefits of investments of CEE twin research (Molnár et al, 2013;Tarnoki et al, 2012;. Of note, collaboration with other twin registries and researchers, such as the Italian Twin Registry (thanks to the continuous support of the head, Professor Maria Antonietta Stazi, and her colleagues) and Professor Kirsi Pietiläinen from the University of Helsinki, Finland, has made our work smoother.…”

Section: Guest Editorialmentioning

confidence: 99%

Central and Eastern European Special Issue

Littvay¹,

Métneki²,

Tárnoki

et al. 2014

Twin Res Hum Genet

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From November 16–19, 2014, twin researchers of the world will descend on the lovely city of Budapest, Hungary for the 3rd World Congress on Twin Pregnancy, held in conjunction with the 15th Congress of the International Society of Twin Studies (ISTS). It is the first time a Central and Eastern European country will host the congress. On this occasion, we were honored by the request from the editor of Twin Research and Human Genetics, Nick Martin, to put together a special issue highlighting twin research conducted in Central and Eastern Europe (CEE).

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“…Százkét magyar ikerpár vena femoralis communisának anteroposterior és mediolateralis át-mérőit mérve sikerült kimutatni, hogy a vena femoralis kapacitása és elaszticitása 36-39% között örökletes, továbbá a vénás kapacitás és elaszticitás viszonylag erős genetikai összefüggést mutat a testsúllyal [44].…”

Section: Az Artériás Stiffness éS a Centrális Hemodinamika Vizsgálataunclassified

Hungarian twin studies: results of four decades

Tárnoki

Horváth

et al. 2013

Orvosi Hetilap

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Az ikervizsgálatok szerepet játszanak a fenotípusos változók kialakulásáért felelős genetikai és környezeti tényezők arányának, továbbá a genotípusok közötti genetikai kapcsoltság vizsgálatában. Magyarországon az ikerkutatások dön-tően az 1970-es években kezdődtek és alapjukat három ikernyilvántartás (köztük két iker-regiszter) biztosította. A vizsgálatok elsősorban a különböző veleszületett rendellenességekre, a fogamzásgátló tabletták és a folsav ikergyakoriságra való hatására, az ikrek pszichoszexuális viselkedésének megismerésére, az alkoholfogyasztási szokások örökletességének becslésére irányultak. Először mutatták ki a laktóz(mal)abszorpció monogénes mendeli öröklődé-sét. 2007-ben alakult meg a Magyar Ikerregiszter, amelynek segítségével több ikervizsgálatra nyílt ismét lehetőség, például a metabolikus szindróma és az érelmeszesedés hátterének megértésére. Nemzetközi ikervizsgálat során többek között az artériás stiffness, a centrális vérnyomás, a carotis intima/media falvastagság, a vénás biomechanika, a testösszetétel, a légzésfunkció és a dohányzási szokások vizsgálatára is sor került. Először sikerült kimutatni a nem alkoholos zsírmáj örökletességének hiányát és a carotisplakkok kialakulásában az öröklődés szerepét. A dolgozat a Magyar Ikerregiszter jövőbeni terveiről is áttekintést nyújt. Orv. Hetil., 2013, 154, 1579-1586. Kulcsszavak: ikerregiszter, öröklődés, környezet, epigenetika, ikerterhesség Hungarian twin studies: results of four decadesTwin studies play a role in examining the contribution of genetic variations and environmental factors responsible for the determination of phenotypic variables and of genetic linkage between genotypes. Hungarian twin studies, supported by three twin registries (among them two twin-database), date back to 1970s. Studies mainly focused on various congenital abnormalities, the effect of contraceptive pills and folic acid on the frequency of twin pregnancies, as well as psychosexual and alcohol consumptional behaviors. Monogenic Mendelian inheritance of lactose (mal) absorption was demonstrated for the fi rst time. Hungarian Twin Registry was founded in 2007, which contributed to the current understanding on the background of several disorders, e.g. metabolic syndrome and atherosclerosis. As part of an international twin study, among others, arterial stiffness, central blood pressure, carotid intima/media thickness, venous biomechanics, body composition, lung function and smoking characteristics were also assessed. Absence of genetic background in non-alcoholic fatty liver disease and high inheritance of carotid plaque characteristics were demonstrated for the fi rst time. The review also aims to summarize future plans of the Hungarian Twin Registry.

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Heritability of Venous Biomechanics

Abstract: Objective-Altered venous biomechanics may contribute to the pathogenesis of venous diseases, and their heritability is less known.

Cited by 6 publications

References 34 publications

Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

Heritability of the dimensions, compliance and distensibility of the human internal jugular vein wall

Central and Eastern European Special Issue

Hungarian twin studies: results of four decades

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