Heritability, parental transmission and environment correlation of pediatric-onset type 2 diabetes mellitus and metabolic syndrome-related traits

Miranda-Lora, América Liliana; Vilchis-Gil, Jenny; Molina‐Díaz, Mario; Flores-Huerta, Samuel; Klünder-Klünder, Miguel

doi:10.1016/j.diabres.2017.02.005

Cited by 17 publications

(16 citation statements)

References 29 publications

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“…There is strong evidence for familial clustering and genetic predisposition to T2D in Mexican people (mainly at younger ages) . In this population, we have identified an association between the rs13342232 variant of the SLC16A11 gene and pediatric‐onset T2D .…”

Section: Introductionmentioning

confidence: 66%

“…13 There is strong evidence for familial clustering and genetic predisposition to T2D in Mexican people (mainly at younger ages). 14 In this population, we have identified an association between the rs13342232 variant of the SLC16A11 gene and pediatric-onset T2D. 15 More recently, we also reported the associations of GNPDA2/ rs10938397, FTO/rs9939609, ADORA1/rs903361, CADM2/ rs13078807 and VEGFA/rs6905288 with pediatric-onset T2D in a case-control study.…”

mentioning

confidence: 79%

“…Significant family aggregation of T2D has been reported, because of the sharing of genetic and environmental risk factors among relatives. In this regard, we previously reported a greater correlation of T2D with the maternal than the paternal line, and this observation could be related to preferential parental transmission of risk alleles . Some susceptibility variants for T2D may depend on the parent from whom they are inherited .…”

Section: Discussionmentioning

confidence: 99%

“…To increase statistical power, in this study, we collected genetic information from parents. These family data also allowed us to test a parent‐of‐origin effect, which could explain the correlation differences between maternal and paternal histories of T2D previously reported in our population …”

Section: Introductionmentioning

confidence: 99%

“…These family data also allowed us to test a parentof-origin effect, which could explain the correlation differences between maternal and paternal histories of T2D previously reported in our population. 14 Overall, the objective of this study was to analyze the association with pediatric-onset T2D and parental transmission of 64 obesityrelated polymorphisms in Mexican families.…”

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confidence: 99%

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Genetic polymorphisms associated with pediatric‐onset type 2 diabetes: A family‐based transmission disequilibrium test and case‐control study

et al. 2019

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Background and Objective Genetics play a very strong role in the development of pediatric‐onset type 2 diabetes (T2D); however, little information exists about specific common single nucleotide polymorphisms (SNPs) associated with T2D in this age group. The aim of the study was to analyze the association and parental transmission of 64 obesity‐related SNPs with pediatric‐onset T2D in Mexican families. Methods A total of 57 pedigrees containing 171 probands with pediatric‐onset T2D and 119 unrelated controls older than 18 years were included. The participants were genotyped for 64 polymorphisms. Association of each variant with pediatric‐onset T2D was analyzed through a parent‐offspring transmission disequilibrium test (TDT) and in a case‐control comparison by χ2 analysis. Results Five SNPs exhibited associations with pediatric‐onset T2D in the combined case‐parent trio and case‐control analysis: LINGO/rs10968576 (odds ratio [OR] 1.82, P = 0.003), POC5/rs2112347 (OR 1.96, P = 2.4E‐5), RPS10‐NUDT3/rs206936 (OR 1.40, P = 0.023), GLIS3/rs7034200 (OR 2.34, P = 1.2E‐6), and VEGFA/rs6905288 (OR 1.58, P = 0.015). The first three were also associated with obesity status. The SNPs POC5/rs2112347 and RPS10‐NUDT3/rs206936 were significantly associated through the maternal allele and GLIS3/rs7034200 through the paternal allele (P < 0.05). Conclusions These findings suggest that certain SNPs associated with obesity and other metabolic traits may also be involved in risk of pediatric‐onset T2D in Mexican families. We also identified preferential transmission of parental alleles in some variants.

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Section: Introductionmentioning

confidence: 66%

mentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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