Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation

Nakajima, Hidehiro; Nakajima, Hisako O.; Soonpaa, Mark H.; Jing, Shaoliang; Field, Loren J.

doi:10.1038/sj.onc.1203266

Cited by 11 publications

(15 citation statements)

References 16 publications

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“…Additionally, males had slightly higher thymoma risk than females. Animal models of thymoma offer conflicting evidence on the importance of sex and reproductive hormones 18, 19. We did not find significantly elevated (or reduced) risk for tumors of reproductive organs among thymoma patients, arguing against a role for hormonal factors.…”

Section: Discussioncontrasting

confidence: 66%

The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence

Armstrong

Goldstein

Shera

et al. 2003

Cancer

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Ein in ein Polymer eingebetteter, panchromatischer Bodipy‐Absorber mit eingebautem Energiegradienten konzentriert einfallende Sonnenstrahlung an einem endständigen Chromophor und erzeugt so eine monochromatische Emission an den Seiten des Polymer‐Wellenleiters (siehe Bild). Dieses besondere Design minimiert Selbstabsorptionsverluste der peripheren Antennen‐Einheiten mit einem beeindruckenden S‐Faktor von 10 000.

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Section: Discussioncontrasting

confidence: 66%

The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence

Armstrong

Goldstein

Shera

et al. 2003

Cancer

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“…Translocation encompassing the analogous region in humans has been implicated in lymphoepithelial thymoma. 19 Spontaneous cases of human type B3 and type C thymomas showed chromosomal imbalances, with a gain in various chromosome segments or loss of entire chromosomes. Type A thymomas did not reveal chromosomal gains or losses.…”

Section: Discussionmentioning

confidence: 99%

Comparative Morphologic and Immunohistochemical Investigation of Spontaneously Occurring Thymomas in a Colony of European Hamsters

Brandes

Fend²,

Monecke

et al. 2004

Vet Pathol

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Abstract. This study documents the characteristics of a large series of spontaneously occurring thymomas in a laboratory colony of European hamsters (Cricetus cricetus). Thymomas are rare organotypic neoplasms originating from the thymic epithelial compartment. Because the hamster thymomas largely resembled their human counterparts, the recent World Health Organization (WHO) classification of human thymic epithelial tumors was used. Forty hamsters of both sexes aged 3-29 months were examined macroscopically and histologically. In 22 (55%) of the 40 animals, necropsy revealed enormous whitish masses in the anterior mediastinum, with a diameter ranging from 0.5 to 4.5 cm and a lobulated structure. The anatomy of the thymus region was normal in the remaining 18 hamsters. Histologically, the tumors presented as thymuslike organoid structures with areas of medullary and cortical differentiation and a predominance of lymphoid cells. A network of epithelial cells in the cortical areas, demonstrated immunohistochemically with a cross-reactive antibody against pancytokeratin, supported the diagnosis of thymoma. Cortical lymphocytes showed positive staining with crossreacting antibodies against CD3 and terminal deoxynucleotidyl transferase, characteristic of immature T cells. On the basis of these findings, the tumors were classified as B1 thymomas, in some cases with AB or B2 components, according to the new WHO classification for human thymic epithelial tumors.

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“…1998). Recently, Nakajima et al . (2000) demonstrated that heritable lympho‐epithelial thymoma was induced in a line of transgenic mice by insertional mutation of a transgene.…”

Section: Discussionmentioning

confidence: 99%

A novel animal model of thymic tumour: Development of epithelial thymoma in transgenic rats carrying human T lymphocyte virus type I pX gene

Kikuchi

Ikeda

Tsuchikawa

et al. 2002

Int J Experimental Path

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Summary. The pX region encodes a major product of human T lymphocyte virus type I (HTLV-I) that has been implicated previously in tumour formation. To investigate the pathogenesis of pX gene in lymphoid tissues, we established a series of novel transgenic rats carrying the pX gene under the control of a rat lymphocyte-specific protein tyrosine kinase (p56lck) proximal promoter. The transgene was constructed with the À269 to 26 region of a rat p56lck proximal promoter and the pX cDNA, and was microinjected into fertilized ova of Fischer 344/jcl female rats. Six transgenic lines from 114 pups were established. Integration and expression of the transgene were detected by polymerase chain reaction (PCR) and Southern hybridization or by reverse transcriptase-PCR, northern hybridization, and immunostaining. ultra-structural analysis characterized the tumour cells to as epithelial cell type, and in the tumour arose in the medulla. Therefore, the tumour is classified into predominantly epithelial and spindle cell of medullary thymoma (type A of the new World Health Organization classification), as based on the human classification. Tumor occurrence increased in proportion to levels of the pX transcription in the thymus, for each line, and sex distinction was evident regarding rates related to tumour expansion. The transgenic rat model described here is suitable as a model for analysing tumorigenesis in epithelial thymoma occurring in humans.

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Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation

Cited by 11 publications

References 16 publications

The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence

The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence

Comparative Morphologic and Immunohistochemical Investigation of Spontaneously Occurring Thymomas in a Colony of European Hamsters

A novel animal model of thymic tumour: Development of epithelial thymoma in transgenic rats carrying human T lymphocyte virus type I pX gene

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