Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy

McCauley, Kathryn; Rackaityte, Elze; LaMere, Brandon; Fadrosh, Douglas; Fujimura, Kei E.; Panzer, Ariane R.; Lin, David L.; Lynch, Kole; Halkias, Joanna; Mendoza, Ventura F.; Burt, Trevor D.; Bendixsen, Casper; Barnes, Kathrine L.; Kim, Hae Jin; Jones, Kyra; Ownby, Dennis R.; Johnson, Christine Cole; Seroogy, Christine M.; Gern, James E.; Boushey, Homer A.; Lynch, Susan V.

doi:10.1016/j.xcrm.2022.100713

Cited by 26 publications

(17 citation statements)

References 91 publications

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“…211 The maternal microbiome may also influence gene expression in fetal T cells, either by direct vertical seeding of microbial populations or the influence of metabolites elicited from them. 39,40,41,42,43,212 Not least, and as discussed previously in the case of T Reg development in responses to NIMAs, 48,57 microchimeric maternal cells in fetal tissues can drive adaptive T Reg development and also contribute to anti-maternal effector responses associated with preterm labor.…”

Section: Control Of Intrauterine Immune System Transitionsmentioning

confidence: 78%

“…Intrauterine physiological hypoxia likely contributes to T Reg differentiation via the influence of the inducible oxygen sensor HIF‐1α and other redox‐sensitive pathways, 208‐210 while maternal nutritional status is well recognized to influence fetal and newborn immune programming 211 . The maternal microbiome may also influence gene expression in fetal T cells, either by direct vertical seeding of microbial populations or the influence of metabolites elicited from them 39,40,41,42,43,212 . Not least, and as discussed previously in the case of T Reg development in responses to NIMAs, 48,57 microchimeric maternal cells in fetal tissues can drive adaptive T Reg development and also contribute to anti‐maternal effector responses associated with preterm labor.…”

Section: Transitions In Human Fetal T Cell Developmentmentioning

confidence: 94%

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Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition

Burt

McCune

2023

Immunological Reviews

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Section: Control Of Intrauterine Immune System Transitionsmentioning

confidence: 78%

Section: Transitions In Human Fetal T Cell Developmentmentioning

confidence: 94%

Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition

Burt

McCune

2023

Immunological Reviews

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“…It has been demonstrated that a reduction in L. jensenii abundance has a close correlation with early-stage embryo arrest [34]. Furthermore, research suggests that L. jensenii may hold potential in facilitating vertical transmission from mother to infant [35].…”

Section: Discussionmentioning

confidence: 99%

Fungal-bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

Chen,

Liu

et al. 2023

Preprint

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Caesarean section scar diverticulum (CSD) is a significant cause of infertility among women who have previously had a Caesarean section, primarily due to persistent inflammatory exudation associated with this condition. Even though abnormal bacterial composition is identified as a critical factor leading to this chronic inflammation, clinical data suggests that a long-term cure is often unattainable with antibiotic treatment alone. In our study, we employed metagenomic analysis and mass spectrometry techniques to investigate the fungal composition in CSD and its interaction with bacteria. We discovered that local fungal abnormalities in CSD can disrupt the stability of the bacterial population and the entire microbial community by altering bacterial abundance via specific metabolites. For instance, Lachnellula suecica reduces the abundance of several Lactobacillus spp., such as Lactobacillus jensenii, by diminishing the production of metabolites like Goyaglycoside A and Janthitrem E. Concurrently, Clavispora lusitaniae and Ophiocordyceps australis can synergistically impact the abundance of Lactobacillus spp. by modulating metabolite abundance. Our findings underscore that abnormal fungal composition and activity are key drivers of local bacterial dysbiosis in CSD.

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“…Additionally, transplanting maternal vaginal microbiota onto neonates delivered via C-section is thought to affect the trajectory of skin and gut bacterial colonization in infants, as differential gut microbial composition has been observed in infants delivered vaginally vs. via C-section [ 149 , 150 ]. A few vaginal seeding trials were identified (NCT03567707, NCT03928431).…”

Section: Targeted Microbial Therapiesmentioning

confidence: 99%

Microbiome Therapeutics for Food Allergy

2022

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The prevalence of food allergies continues to rise, and with limited existing therapeutic options there is a growing need for new and innovative treatments. Food allergies are, in a large part, related to environmental influences on immune tolerance in early life, and represent a significant therapeutic challenge. An expanding body of evidence on molecular mechanisms in murine models and microbiome associations in humans have highlighted the critical role of gut dysbiosis in the pathogenesis of food allergies. As such, the gut microbiome is a rational target for novel strategies aimed at preventing and treating food allergies, and new methods of modifying the gastrointestinal microbiome to combat immune dysregulation represent promising avenues for translation to future clinical practice. In this review, we discuss the intersection between the gut microbiome and the development of food allergies, with particular focus on microbiome therapeutic strategies. These emerging microbiome approaches to food allergies are subject to continued investigation and include dietary interventions, pre- and probiotics, microbiota metabolism-based interventions, and targeted live biotherapeutics. This exciting frontier may reveal disease-modifying food allergy treatments, and deserves careful study through ongoing clinical trials.

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Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy

Cited by 26 publications

References 91 publications

Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition

Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition

Fungal-bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

Microbiome Therapeutics for Food Allergy

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