Hernia Materials: Fundamentals of Prosthetic Characteristics

Deeken, Corey R.; Lake, Spencer P.

doi:10.1007/978-3-319-78411-3_4

Cited by 2 publications

(4 citation statements)

References 59 publications

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“…In the 1940s, silver and tantalum meshes were introduced for hernia repair applications [1,2], and by the late-1950s, permanent synthetic polymer meshes were utilized [3]. In the decades following, more than 150 unique designs have been developed, comprised of permanent synthetic polymers, biological tissue-derived materials, and most recently, resorbable polymers [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Devices in this category are comprised of: poly-4hydroxybutyrate (Phasix TM Mesh, Becton, Dickinson and Company (BD), Franklin Lakes, NJ), ultra-pure fibroin derived from silk (SeriV R Surgical Scaffold, Sofregen Medical), polyglycolic acid (SafilV R Mesh, B Braun), a copolymer of glycolide and lactide (Dexon TM Mesh, Covidien & Vicryl TM Knitted Mesh, Ethicon, Inc.), a co-polymer of polyglycolic acid and trimethylene carbonate (GoreV R Bio-AV R Tissue Reinforcement, W.L. Gore & Assoc., Inc.), and a co-polymer of glycolide, lactide, and trimethylene carbonate (TIGRV R Matrix Surgical Mesh, Insightra Medical) [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair

Deeken¹,

Gagne

Badhwar

2020

Journal of Investigative Surgery

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Purpose: The objective of this study was to determine mechanical and histological properties of Phasix TM ST Mesh in various defect sizes and characterize the tissue replacing Phasix TM ST Mesh in a porcine model of ventral hernia repair. Methods: Simulated hernia defects were surgically created in the midline of twenty-four (n ¼ 24) Yucatan pigs. Treatment groups included 8 cm defect sutured closed (buttress) and unclosed 4 cm and 8 cm defect groups. Phasix TM ST Mesh (15 cm diameter circle) was implanted laparoscopically and fixated circumferentially with SorbaFix TM Absorbable Fixation System fasteners. The repair sites underwent mechanical, molecular weight, and histological evaluation at 48 and 72 weeks postimplantation. Results: Mechanical testing of Phasix TM ST Mesh-repaired sites revealed similar strengths at both time points for all three repair types, p > 0.05 in all cases (48 weeks: 142.4 ± 6.0 N, 142.3 ± 16.5 N, and 168.8 ± 38.5 N; 72 weeks: 110.0 ± 18.3 N, 138.6 ± 42.2 N, and 160.6 ± 42.0 N for 4 cm defect, 8 cm defect, and 8 cm buttress, respectively. mean ± SEM) No significant differences were observed over time except at 72 weeks postimplantation when the 4 cm defect group exhibited significantly lower strength than the T 0 strength of Phasix TM ST Mesh (204.6 ± 5.0 N, p < 0.05). The molecular weight of Phasix TM ST Mesh decreased over time, regardless of repair type. Histological analysis showed comparable mature collagen/fibrovascular tissue around and within the Phasix TM ST Mesh interstices, including the segment of mesh overlying the defect. Conclusion: Phasix TM ST Mesh-repaired sites exhibited similar mechanical strengths and histological properties across all defect sizes in this porcine model.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair

Deeken¹,

Gagne

Badhwar

2020

Journal of Investigative Surgery

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“…The suture pull out test, which is used to determine the suture tearing out resistance of surgical knitted meshes with suture threads, is a crucial test for the final implantation of the mesh inside the human body, proving the effective fixation of the implant. Moreover, the suture pull out strength is recommended in the literature to be 20 N. 32 The suture pull out strength of the mesh must be greater than this value to ensure safe fixation. Therefore, centered points were marked at a distance of 2 mm to the longer cutting edge, while, for the latter, the marking was in the third undamaged knitting loop (counted from the cutting edge) in the center of the longitudinal cut on each side.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Mechanical Properties of Smart Polypropylene Meshes: Effects of Mesh Architecture, Plasma Treatment, Thermosensitive Coating, and Sterilization Process

Lanzalaco

Weis

Traeger

et al. 2023

ACS Biomater. Sci. Eng.

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Smart polypropylene (PP) hernia meshes were proposed to detect surgical infections and to regulate cell attachment-modulated properties. For this purpose, lightweight and midweight meshes were modified by applying a plasma treatment for subsequent grafting of a thermosensitive hydrogel, poly(N-isopropylacrylamide) (PNIPAAm). However, both the physical treatment with plasma and the chemical processes required for the covalent incorporation of PNIPAAm can modify the mechanical properties of the mesh and thus have an influence in hernia repair procedures. In this work, the mechanical performance of plasma-treated and hydrogel-grafted meshes preheated at 37 °C has been compared with standard meshes using bursting and the suture pull out tests. Furthermore, the influence of the mesh architecture, the amount of grafted hydrogel, and the sterilization process on such properties have been examined. Results reveal that although the plasma treatment reduces the bursting and suture pull out forces, the thermosensitive hydrogel improves the mechanical resistance of the meshes. Moreover, the mechanical performance of the meshes coated with the PNIPAAm hydrogel is not influenced by ethylene oxide gas sterilization. Micrographs of the broken meshes evidence the role of the hydrogel as reinforcing coating for the PP filaments. Overall, results confirm that the modification of PP medical textiles with a biocompatible thermosensitive hydrogel do not affect, and even improve, the mechanical requirements necessary for the implantation of these prostheses in vivo.

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Hernia Materials: Fundamentals of Prosthetic Characteristics

Cited by 2 publications

References 59 publications

Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair

Mechanical and Histological Characteristics of Phasix™ ST Mesh in a Porcine Model of Hernia Repair

Mechanical Properties of Smart Polypropylene Meshes: Effects of Mesh Architecture, Plasma Treatment, Thermosensitive Coating, and Sterilization Process

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