Hernia Mesh and Hernia Repair: A Review

See, Carmine Wang; Kim, Tiffany; Zhu, Donghui

doi:10.1016/j.engreg.2020.05.002

Cited by 53 publications

(37 citation statements)

References 104 publications

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“…From a clinical perspective, hernias are caused by the protrusion of internal organs out of the abdomen, mainly due to the presence of a weak spot or a hole into the surrounding connective and muscular tissue [2,23] and can be classified into two different groups according to the protrusion location. Groin hernias are located in the bottom half of the body [24]. They mainly affect the male population with an incidence between the 27 and 43% [25].…”

Section: Herniamentioning

confidence: 99%

“…They mainly affect the male population with an incidence between the 27 and 43% [25]. Ventral hernias are located in the superior half of the body [24], and many times, they are referred to us as incisional hernias, since occur as consequence of weaknesses developed after laparoscopic abdominal surgery [26]. The current treatment of hernia includes mesh-based surgery, with 91,673 operations performed in 2018 in UK [12].…”

Section: Herniamentioning

confidence: 99%

“…Traditional surgical procedures consisted of the superimposition of tissues which were not normally overlapped, thus introducing undesirable tension [27]. Lichtenstein approach consists in the fixation of the mesh (via tissue glues, tacks, staples or stitches) onto the aponeurotic tissue after having made an incision above the defect, thus considerably decreasing the level of tension to which the tissue will be subjected [24,27]. Unfortunately, Lichtenstein…”

Section: Herniamentioning

confidence: 99%

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Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

2021

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Surgical meshes have been employed in the management of a variety of pathological conditions including hernia, pelvic floor dysfunctions, periodontal guided bone regeneration, wound healing and more recently for breast plastic surgery after mastectomy. These common pathologies affect a wide portion of the worldwide population; therefore, an effective and enhanced treatment is crucial to ameliorate patients’ living conditions both from medical and aesthetic points of view. At present, non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia, pelvic floor dysfunctions and guided bone regeneration, with polypropylene and poly tetrafluoroethylene being the most common. Biological prostheses, such as surgical grafts, have been employed mainly for breast plastic surgery and wound healing applications. Despite the advantages of mesh implants to the treatment of these conditions, there are still many drawbacks, mainly related to the arising of a huge number of post-operative complications, among which infections are the most common. Developing a mesh that could appropriately integrate with the native tissue, promote its healing and constructive remodelling, is the key aim of ongoing research in the area of surgical mesh implants. To this end, the adoption of new biomaterials including absorbable and natural polymers, the use of drugs and advanced manufacturing technologies, such as 3D printing and electrospinning, are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical practice. The aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes, the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations. Graphic abstract

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Section: Herniamentioning

confidence: 99%

Section: Herniamentioning

confidence: 99%

Section: Herniamentioning

confidence: 99%

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Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

2021

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“…Nonetheless, there are a host of issues with polyprolene mesh, resulting in complications reviewed by Gavlin et al (2020) . Two common complications of synthetic meshes are infection and fibrosis, triggering chronic inflammation and discomfort to the patient ( Wang See et al, 2020 ).…”

Section: Musclementioning

confidence: 99%

Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials

Karkanitsa

Fathi

Ngo

et al. 2021

Front. Bioeng. Biotechnol.

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With few exceptions, humans are incapable of fully recovering from severe physical trauma. Due to these limitations, the field of regenerative medicine seeks to find clinically viable ways to repair permanently damaged tissue. There are two main approaches to regenerative medicine: promoting endogenous repair of the wound, or transplanting a material to replace the injured tissue. In recent years, these two methods have fused with the development of biomaterials that act as a scaffold and mobilize the body’s natural healing capabilities. This process involves not only promoting stem cell behavior, but by also inducing activity of the immune system. Through understanding the immune interactions with biomaterials, we can understand how the immune system participates in regeneration and wound healing. In this review, we will focus on biomaterials that promote endogenous tissue repair, with discussion on their interactions with the immune system.

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“…Possible nonlinearities may appear on the geometrical level as well as on the material level -for instance due to hyperelastic or inelastic material behaviour in the micro-structure. Examples of materials combining both geometric and material nonlinearities include cushioning shoe soles [6], synthetic meshes, used for example in hernia repair surgery [7] and impact absorbing materials used in defence applications such as body and object protection [8][9][10]. The latter is designed to absorb maximum energy at nearly constant stress.…”

Section: Introductionmentioning

confidence: 99%

Homogenization of fully nonlinear rod lattice structures: on the size of the RVE and micro structural instabilities

Herrnböck

Steinmann

2021

Comput Mech

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This work investigates the possibility of applying two-scale computational homogenization to rod lattice structures emerging, for instance, from additive manufacturing. The influence of the number of unit cells within the representative volume element (RVE), thus, the RVE’s size on the homogenized mechanical response is studied for occurring microscopic structural instabilities. Therein, the macro-scale, described in terms of three-dimensional continuum mechanics, is coupled to the micro-scale described by geometrically exact rods, enabling arbitrary large deformations and rotations. A special feature of the presented framework is that the rods building the lattice structures are not restricted to deform purely elastically but may deform inelastically. The mechanical response of lattice structures is investigated by applying the developed homogenization method to an exemplary lattice. Under special loads the structure reaches an instable state and may buckle. The appearance of instabilities depends on the geometric properties of the lattice’s underlying rods and the RVE’s size.

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Hernia Mesh and Hernia Repair: A Review

Cited by 53 publications

References 104 publications

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

Mobilizing Endogenous Repair Through Understanding Immune Reaction With Biomaterials

Homogenization of fully nonlinear rod lattice structures: on the size of the RVE and micro structural instabilities

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