Herpes Labialis: A New Possibility for Topical Treatment with Well-Elucidated Drugs

Silva-Alvarez, Amanda F; Carvalho, Ana Clara Wada de; Benassi-Zanqueta, Érica; Oliveira, Thalita Zago; Fonseca, Dyenefer Pereira; Ferreira, M. P.; Vicentini, Fabiana T. M. C.; Ueda-Nakamura, Tânia; Pedrazzi, Vinícius; Freitas, Osvaldo de

doi:10.1016/j.xphs.2021.06.029

Cited by 4 publications

(2 citation statements)

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“…25,26 There are several triggers that can reactivate herpesviruses and among them are specific hormonal conditions, stress, weather conditions such as cold, and solar radiation or conditions in which depression or activation of the immune system occurs. 26,30,31 Local trauma, insect bites, 27,30,32 pharmacological idiosyncrasies and genetic susceptibility 32,33 have also been cited as triggers. It is important to consider that some medications that act on the immune system can cause reactivation; however, if essential, they should not be interrupted.…”

Section: What This Study Addsmentioning

confidence: 99%

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L‐lysine: Its antagonism with L‐arginine in controlling viral infection. Narrative literature review

Pedrazini

Silva²,

Groppo

2022

Brit J Clinical Pharma

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Knowledge about viral characteristics, mechanisms of entry into the host cell and multiplication/dissemination can help in the control and treatment of viral pathologies. Several nutritional factors linked to the host may favour viral multiplication and their control, may lead to new prophylactic alternatives and/or antiviral therapies.The objective of this review is to discuss the relationship between the amino acid Llysine and the control of viral infections, aiming at a possible therapeutic property.This research used databases such as PubMed, Web of Science, Scielo, Medline and Google Scholar, as well as searching for references cited by journals. The time frame covered the period between 1964 and January 2022. The observed studies have shown that the usual antiviral therapies are not able to interfere with the viruses in their latent state; however, they can interfere with the adhesion and fusion of viral particles or the production of proteins, which play an important role in viral epidemiology and control, particularly in the initial moment and in reactivation. Lysine is an amino acid that can interfere mainly in the formation of capsid proteins and DNA by a competitive antagonism with amino acid arginine, which is an essential amino acid for some viruses, and also by promoting the increase of arginase, increasing the catabolism of arginine. Although there is evidence of the importance of L-lysine in viral control, more studies are needed, with a view to new antiviral therapies.

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Section: What This Study Addsmentioning

confidence: 99%

“…19,20,53,54 In the case of herpes simplex in addition to acyclovir, other DNA polymerase inhibitors, virus fusion inhibitors or nucleoside analogues can be used, some of which are reserved for immunocompromised patients with severe herpes simplex. 15,31,54…”

Section: What This Study Addsmentioning

confidence: 99%