Herpes-like Virus Infection in Yangtze Finless Porpoise (Neophocaena phocaenoides): Pathology, Ultrastructure and Molecular Analysis

Pei, Chao; Lei, Xiao Ying; Yuan, Xiu; Wang, Ding; Zhao, Qing; Zhang, Qi Ya

doi:10.7589/0090-3558-48.1.235

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…Previous research demonstrated that cyprinids were one of the main foods for the Yangtze finless porpoise (39)(40)(41)(42)(43). Moreover, Pei et al also found herpes virus in the liver of dead Yangtze finless porpoise, which was consistent with our results (44). Therefore, further research is needed to determine whether the Yangtze finless porpoise can infect the herpes virus through the food chain.…”

Section: Discussionsupporting

confidence: 91%

A metagenomic insight into the Yangtze finless porpoise virome

et al. 2022

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The Yangtze finless porpoise (Neophocaena phocaenoides asiaeorientalis) inhabiting the Yantze River, China is critically endangered because of the influences of infectious disease, human activity, and water contamination. Viral diseases are one of the crucial factors that threatening the health of Yangtze finless porpoise. However, there are few studies which elaborate the viral diversity of Yangtze finless. Therefore, this study was performed to investigate the viral diversity of Yangtze finless by metagenomics. Results indicated that a total of 12,686,252 high-quality valid sequences were acquired and 2,172 virus reads were recognized. Additionally, we also obtained a total of 10,600 contigs. Phages was the most abundant virus in the samples and the ratio of DNA and RNA viruses were 69.75 and 30.25%, respectively. Arenaviridae, Ackermannviridae and Siphoviridae were the three most predominant families in all the samples. Moreover, the majority of viral genus were Mammarenavirus, Limestonevirus and Lambdavirus. The results of gene prediction indicated that these viruses play vital roles in biological process, cellular component, molecular function, and disease. To the best of our knowledge, this is the first report on the viral diversity of Yangtze finless porpoise, which filled the gaps in its viral information. Meanwhile, this study can also provide a theoretical basis for the establishment of the prevention and protection system for virus disease of Yangtze finless porpoise.

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Section: Discussionsupporting

confidence: 91%

A metagenomic insight into the Yangtze finless porpoise virome

et al. 2022

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“…12, 18, and 29), 12 mild (Nos. 2,11,19,24,26,28,30, and 32-36), 6 moderate (Nos. 1, 5, 6, 9, 10, and 13), and 1 very marked hepatitis (No.…”

Section: Necropsy Resultsmentioning

confidence: 99%

“…Reported causes of hepatic lesions in case studies of cetaceans include a variety of bacterial, 12,21 viral, 19,23,28 trematode (Campula sp. ), 3,9,12,15,23 and protozoal 23 infections, lipidosis, 3,23,30 amyloidosis, 26 hemochromatosis, 30 nonspecific reactive hepatitis, 9 and neoplasia.…”

mentioning

confidence: 99%

Beyond Parasitism

et al. 2014

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The liver can be an indicator of the health of an individual or of a group, which can be especially important to identify agents that can cause disease in multiple species. To better characterize hepatic lesions in stranded harbor porpoises (Phocoena phocoena), we analyzed the livers from 39 porpoises that stranded along the Dutch coast between December 2008 and December 2012. The animals were selected because they had either gross or histologic liver lesions with minimal autolysis and no evidence of trematode (Campula oblonga) infection. The most common finding was a chronic hepatitis (22/39, 56.4%) that was often associated with significant disease reported in another organ system (18/22, 81.8%), of which 14 had chronic systemic disease. One case of chronic hepatitis was so severe as to mimic lymphoma, which could only be differentiated with immunohistochemistry. The other common lesions were lipidosis (11/39, 28.2%) and acute hepatitis (6/39, 15.4%), often in combination with mild chronic changes. Overall, although there were no consistent trends in etiology for the hepatic lesions, lipidosis was associated with starvation (8/11, 72.7%) and acute disease, and acute hepatitis was associated with bacterial infections and sepsis (6/6, 100%).

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“…Therefore, the fecal microbiome of YFPs showed that the animals have the stability to be able to resist the low-abundance of potential pathogens. However, we need to stay alert and prevent the relative abundance of potential pathogens from growing over to a certain extent, thereby affecting the animals' health [57]. Thus, this result has certain guidance to the work of Anqing Xijiang YFP ex situ conservation base.…”

Section: Discussionmentioning

confidence: 99%

Changes in the fecal microbiome of the Yangtze finless porpoise during a short-term therapeutic treatment

You

Ying

et al. 2020

Open Life Sciences

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AbstractThe fecal microbiome is an integral part of aquatic mammals, like an inner organ. But we know very little about this inner organ of the threatened aquatic species, Yangtze finless porpoise (YFP). Four YFPs were placed into a purse seine for skin ulceration treatment, and this opportunity was taken to nurse the animals closer. In particular, we collected the feces of the YFPs before and after the paired healing and therapeutic treatment, along with samples of their fish diet and water habitat, to explore the changes in their fecal microbiome. Firmicutes (20.9–96.1%), Proteobacteria (3.8–78.7%), Actinobacteria (0.1–35.0%) and Tenericutes (0.8–17.1%) were the most dominant phyla present in the feces. The proportion of Proteobacteria and Actinobacteria increased after the treatment. Firmicutes showed a significant decrease, and most potential pathogens were absent, which reflected the administration of ciprofloxacin hydrochloride. Moreover, environmental shifts can also contribute to changes in the fecal microbiome. These results indicate that certain microbial interactions can be affected by environmental shifts, dietary changes and health-care treatments, which can also help maintain the internal environment of YFPs. These findings will inform the future enhanced protection and management of endangered YFPs and other vulnerable aquatic animals.

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Herpes-like Virus Infection in Yangtze Finless Porpoise (Neophocaena phocaenoides): Pathology, Ultrastructure and Molecular Analysis

Cited by 9 publications

References 6 publications

A metagenomic insight into the Yangtze finless porpoise virome

A metagenomic insight into the Yangtze finless porpoise virome

Beyond Parasitism

Changes in the fecal microbiome of the Yangtze finless porpoise during a short-term therapeutic treatment

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