Herpes Simplex and Eosinophilic Oesophagitis: The Chicken or the Egg?

Squires, Katharine A. G.; Cameron, Donald J. S.; Oliver, Mark; Junqueira, José Cesar da Fonseca

doi:10.1097/mpg.0b013e31817b5b73

Cited by 42 publications

(41 citation statements)

References 12 publications

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“…It is important to note that EoE frequently recurs when steroid therapy is discontinued, and the approach to long-term maintenance medical therapy is still unclear (2). Although well tolerated compared to systemic steroids, swallowed corticosteroids do carry a small risk of candidal esophagitis (28). …”

Section: Discussionmentioning

confidence: 99%

Eosinophilic esophagitis in cystic fibrosis: A case series and review of the literature

Goralski

Lercher

Davis

et al. 2013

Journal of Cystic Fibrosis

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Patients with cystic fibrosis (CF) frequently experience gastrointestinal symptoms including nausea, emesis, malnutrition and indigestion; diseases such as gastroesophageal reflux disease (GERD), distal intestinal obstructive syndrome, and cholelithiasis are commonly implicated. We have recently diagnosed eosinophilic esophagitis (EoE) in three patients with CF. EoE is a TH-2 driven, allergen-mediated disease which causes esophageal eosinophilia and presents with symptoms of nausea, feeding intolerance, regurgitation, and dysphagia. EoE is diagnosed when esophageal biopsies reveal greater than 15 eosinophils per high power field in the setting of the appropriate clinical scenario and after exclusion of other causes of esophageal eosinophilia. Although described with increasing frequently in the gastrointestinal literature, there have been no prior cases documenting the co-existence of EoE and CF. We speculate that this is related to lack of familiarity with EoE symptoms by CF providers. We present three patients with CF diagnosed with EoE and review the current literature regarding diagnosis and management, focusing on management issues in patients with CF.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic esophagitis in cystic fibrosis: A case series and review of the literature

Goralski

Lercher

Davis

et al. 2013

Journal of Cystic Fibrosis

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show abstract

“…Interestingly, cases of EoE after ulceration as a result of herpes simplex virus infection have been documented. 19 …”

Section: Pathogenesismentioning

confidence: 97%

Eosinophilic esophagitis: a clinical, endoscopic, and histopathologic review

Ali

Lam-Himlin

Voltaggio

2012

Gastrointestinal Endoscopy

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“…This association has been described in paediatric patients at the time of diagnosis [97,98] and, in contrast with common cases of HSV primary infection or reactivation, in EoE patients the infection appeared in immunocompetent individuals. This finding gives rise to the speculation that active inflammation of the oesophageal squamous epithelium may be a risk factor for acquiring HSV infections [99].…”

Section: A C C E P T E D Accepted Manuscript Between Hp Infection Andmentioning

confidence: 80%

Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia

Lucendo

2015

Best Practice & Research Clinical Gastroenterology

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Herpes Simplex and Eosinophilic Oesophagitis: The Chicken or the Egg?

Cited by 42 publications

References 12 publications

Eosinophilic esophagitis in cystic fibrosis: A case series and review of the literature

Eosinophilic esophagitis in cystic fibrosis: A case series and review of the literature

Eosinophilic esophagitis: a clinical, endoscopic, and histopathologic review

Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia

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