Herpes Simplex Virus Associated With Recurrent Stevens-Johnson Syndrome

Abstract

We describe a 36-year-old man with recurrent Stevens-Johnson syndrome, which became progressively more severe over a 13-year period. His episodes were apparently preceded by herpes simplex virus oral mucosal infections. A management protocol, including immediate therapy with acyclovir and prednisone at the onset of herpes simplex virus oropharyngitis, is outlined. This management strategy has successfully prevented four subsequent episodes of progression to Stevens-Johnson syndrome. Thus, Stevens-Johnson syndrome associated with herpes simplex virus may be prevented by early use of acyclovir and prednisone.

Stevens–Johnson Syndrome and Herpes Simplex Type 1 Infection during Adalimumab Therapy for Crohn’s Disease

“…On the other hand, herpes simplex type 1 infection is also a well-known cause of SJS and one of the most frequent triggers of erythema multiforme [10,11]. In 1992, Detjen et al described a case of SJS in a 36-year-old man with recurrent HSV-related oropharyngitis; even in this case, as in ours, the patient was treated with antivirals and steroids, achieving complete resolution of signs and symptoms [12].…”

Steven Johnson Syndrome in a 102-Year-Old Woman in Saudi Arabia: A Case Report

“…Roujeau et al point out that protopathic bias may be to blame for the association between SJS and TEN and drugs such as acetaminophen, ibuprofen, and secretolytics [9]. HIV, the herpes virus, and mycoplasma pneumonia are among the illnesses that have been related to these disorders [10,11]. A febrile illness is followed by cutaneous erythema with blister development, skin and mucous membrane necrosis, and separation of the skin and mucous membranes in the acute phase of SJS and TEN.…”

Recurrent Stevens-Johnson Syndrome Secondary to Herpes Simplex: A Follow Up on a Successful Management Program

“…We previously described a patient with recurrent severe Stevens-Johnson syndrome secondary to herpes stomatitis, who was successfully managed with prophylactic corticosteroids and acyclovir at the onset of his herpetic lesions. 10 Four years later, the outcome of this regimen in the management of 17 subsequent episodes is described.…”