Herpes Simplex Virus Colitis in a Patient with Newly Diagnosed Crohn’s Disease

Jafri, Hassaan; Kalina, Dale; Aziz, Tariq; Serrano, Pablo E.; Haider, Shariq

doi:10.1155/2018/7591709

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…All patients presented with symptoms suggestive of acute severe UC, and initial treatment consisted of corticosteroids followed by cyclosporine [ 4 ], anti-tumor necrosis factor-inhibitors [ 7 ], or combination therapy with tacrolimus and azathioprine [ 3 ]. The diagnosis of HSV colitis was made on biopsy in only one case [ 6 ] and similar to our case, bowel perforation with subsequent surgery occurred in three patients and HSV was therefore detected with delay [ 5–7 ]. In three cases, HSV-2 was found [ 6 , 8 , 9 ]; in the remaining patients, the genotype was not characterized [ 3–5 , 7 ].…”

Section: Discussionmentioning

confidence: 56%

Herpes simplex virus colitis mimicking acute severe ulcerative colitis: a case report and review of the literature

Cathomas¹,

Rosenberg²,

Burri

et al. 2023

Journal of Surgical Case Reports

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A 60-year-old female patient with longstanding left-sided ulcerative colitis presented with symptoms mimicking an acute flare and developed a colonic perforation shortly after starting steroid treatment. Following left hemicolectomy and Hartmann’s procedure, rescue treatment with infliximab was started. Within a few days, the patient developed hepatic failure. Histology and immunohistochemistry of the specimen revealed extensive necrotizing herpes simplex virus colitis, and liver biopsy demonstrated herpes simplex virus hepatitis. Sixteen days after admission, the patient died from multiorgan failure. This compelling case of severe herpes simplex virus colitis raises awareness of a rare but potentially detrimental infection in patients with inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 56%

Herpes simplex virus colitis mimicking acute severe ulcerative colitis: a case report and review of the literature

Cathomas¹,

Rosenberg²,

Burri

et al. 2023

Journal of Surgical Case Reports

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“…For prevention, there may be a role for prophylactic antiviral therapy in patients who are immunocompromised with serological evidence of latent HSV infections or a history of disseminated or tissue-invasive infections [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Herpes Simplex Virus Colitis in an Immunosuppressed Patient

Tidwell,

Nguyen,

Forouhar

et al. 2023

Cureus

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Herpes simplex virus (HSV) can cause severe disseminated infections in immunocompromised patients. Gastrointestinal tract involvement seldom includes the colon. We present a rare case of disseminated cutaneous HSV infection with concomitant colonic involvement in an immunosuppressed patient. The patient's clinical presentation and computerized tomography (CT) findings were concerning for colitis. She failed to improve on antibiotic therapy and subsequently underwent flexible sigmoidoscopy. Gross findings and histopathology were consistent with herpes simplex virus colitis. It is essential to recognize this pathology in immunocompromised patients to evaluate the need to hold immunosuppressive therapy and ensure successful treatment to prevent fatal outcomes.

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“…19 Herpes simplex virus colitis presents as severe persistent diarrhea and is often associated with abdominal pain, fever, and weight loss. 20 The diagnosis of HSV colitis is made by histological evaluation of colonic mucosa with immunohistochemistry stain. 7,13 Early treatment has been observed to correlate with improved outcomes.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Cytomegalovirus and Herpes Simplex Virus Coinfection Gastritis and Colitis in a Person Living With HIV/AIDS

Huang

Qamar

Gancher

2021

Infect Dis Clin Pract

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Herpes simplex virus (HSV) colitis and gastritis is a very rare gastrointestinal manifestation in immunocompromised patients. We report the case of a 46-year-old man with a medical history of poorly controlled HIV/AIDS who presented with 2 months of progressively worsening nonbloody diarrhea. Esophagogastroduodenoscopy showed gastritis and sigmoidoscopy revealed severe colitis. Biopsy immunostaining revealed cytomegalovirus and HSV viral inclusions in the stomach, appendix, and rectum. The patient's symptoms largely improved with ganciclovir. To our knowledge, this is the first case demonstrating cytomegalovirus and HSV coinfection gastritis and colitis in a patient with HIV/AIDS.

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Herpes Simplex Virus Colitis in a Patient with Newly Diagnosed Crohn’s Disease

Cited by 7 publications

References 13 publications

Herpes simplex virus colitis mimicking acute severe ulcerative colitis: a case report and review of the literature

Herpes simplex virus colitis mimicking acute severe ulcerative colitis: a case report and review of the literature

A Case of Herpes Simplex Virus Colitis in an Immunosuppressed Patient

A Rare Case of Cytomegalovirus and Herpes Simplex Virus Coinfection Gastritis and Colitis in a Person Living With HIV/AIDS

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