2014
DOI: 10.1128/jvi.01627-14
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Herpes Simplex Virus gE/gI Extracellular Domains Promote Axonal Transport and Spread from Neurons to Epithelial Cells

Abstract: Following reactivation from latency, there are two distinct steps in the spread of herpes simplex virus (HSV) from infected neurons to epithelial cells: (i) anterograde axonal transport of virus particles from neuron bodies to axon tips and (ii) exocytosis and spread of extracellular virions across cell junctions into adjacent epithelial cells. The HSV heterodimeric glycoprotein gE/gI is important for anterograde axonal transport, and gE/gI cytoplasmic domains play important roles in sorting of virus particles… Show more

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Cited by 38 publications
(43 citation statements)
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“…Our current findings with the three-chamber system using an HSV-1 pUS9 basic domain mutant also are similar to our observations with a complete deletion of pUS9 (53). A role for HSV-1 gE/gI extracellular domains in contributing to both anterograde axonal transport and possibly also in the spread from distal axons to nonneuronal cells has been reported recently (14) and adds further support to the notion of redundancy in transport processes essential for viral replication (49).…”
Section: Discussionsupporting
confidence: 79%
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“…Our current findings with the three-chamber system using an HSV-1 pUS9 basic domain mutant also are similar to our observations with a complete deletion of pUS9 (53). A role for HSV-1 gE/gI extracellular domains in contributing to both anterograde axonal transport and possibly also in the spread from distal axons to nonneuronal cells has been reported recently (14) and adds further support to the notion of redundancy in transport processes essential for viral replication (49).…”
Section: Discussionsupporting
confidence: 79%
“…For PrV there is also evidence for pUS9-independent anterograde axonal transport of some viral components (8, 9). In HSV-1 the contribution of pUS9 to these processes is less clearly defined (10-13), although a cooperative role for HSV-1 pUS9 and the viral glycoproteins gE/gI in axonal sorting and/or anterograde axonal transport has been documented (11,12,14).…”
mentioning
confidence: 99%
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“…Virus reactivation from latency is frequent and results in either asymptomatic virus shedding or recurrent herpes disease (1). Two essential events following reactivation of HSV from latently infected sensory neurons are the transport of the virus down nerves to the nerve terminals (anterograde direction) and subsequent spread of the virus from the nerve terminals across into the skin (2, 3).Three highly conserved viral envelope proteins, pUS9, gE, and gI, of HSV-1 and pseudorabies virus (PRV), a swine herpesvirus, are important for virus anterograde axonal transport and spread of infection both in vivo and in vitro (4)(5)(6)(7)(8)(9)(10)(11)(12). pUS9 is the only one of these three envelope proteins essential for PRV anterograde transport and spread.…”
mentioning
confidence: 99%
“…The heterodimer of the products of these genes play important role in cell-to-cell spreading of the virus and other connected functions (Snyder et al 2008;Kratchmarov et al 2013;Howard et al 2014;D C Johnson et al 2001). However we were interested in its part in viral gene expression, an area not well documented.…”
Section: Discussionmentioning
confidence: 99%