Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications

Sausen, Daniel G.; Shechter, Oren; Gallo, Elisa; Dahari, Harel; Borenstein, Ronen

doi:10.3390/cancers15143692

Cited by 10 publications

(3 citation statements)

References 225 publications

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“…Of those who develop cervical cancer, 4360 women will die from the disease [ 2 ]. Most cervical cancer cases result from genital infection with human papillomavirus (HPV) [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous research conducted on the occurrence of cancer among individuals with Human Immunodeficiency Virus (HIV) has mostly been restricted to cancers that are considered Acquired Immunodeficiency Syndrome (AIDS)-defining [ 6 ]. Invasive cervical cancer, non-Hodgkin’s lymphoma, and Kaposi sarcoma are considered AIDS-defining malignancies [ 5 ]. Prior to modern highly active antiretroviral therapy (HAART), individuals who were HIV-positive were nearly twice as likely to develop cancer at much higher rates than the general population [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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An Epidemiological Study of Cervical Cancer Trends among Women with Human Immunodeficiency Virus

Mathis,

Smith,

Crowther

et al. 2024

Healthcare

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The purpose of this study was to examine cervical cancer among women with Human Immunodeficiency Virus (HIV) and to discuss targeted strategies to reduce the risk of developing cervical cancer. This study used retrospective data from surveillance reports collected between January 2001 and December 2012. Women with HIV/Acquired Immunodeficiency Syndrome (AIDS) were linked through a crosswalk file to Florida’s cancer registry database to determine which women developed cervical cancer during this period. We examined the cervical cancer trends using age-adjusted cervical cancer rates to examine the changes over time; the geographic variations in cervical cancer and HIV across service areas using a Geographic Information System (GIS); and finally, the cervical cancer rates among women with HIV compared with the cervical cancer rates in the general population. The results show that, over time, the cervical cancer rates in women with HIV/AIDS decreased; however, we detected increases in the cervical cancer rates among women in the general population. The findings of this study show that more work is required to address cervical cancer. This growing burden of cervical cancer implies that targeted interventions are imperative to improving the health status of women with cervical cancer. If properly addressed, the potential to reduce and prevent cervical cancer is achievable.

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“…Of those who develop cervical cancer, 4360 women will die from the disease [ 2 ]. Most cervical cancer cases result from genital infection with human papillomavirus (HPV) [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Epidemiological Study of Cervical Cancer Trends among Women with Human Immunodeficiency Virus

Mathis,

Smith,

Crowther

et al. 2024

Healthcare

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“…A patient with both HIV-1 and HSV-2 infections has a higher likelihood of transmitting HIV-1 to another [ 7 , 8 ]. There have also been arguments about the relationship between HSV and human papillomavirus (HPV) and HPV-associated cervical carcinoma [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity and Therapeutic Efficacy of a Sendai-Virus-Vectored HSV-2 Vaccine in Mouse and Guinea Pig Models

Ren,

Su,

et al. 2023

Vaccines

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Background: To date, there is no licensed vaccine for preventing herpes simplex virus type 2 (HSV-2). The current treatment to address the infection and prevent its transmission is not always satisfactory. Methods: We constructed two recombinant vectors, one encoding HSV-2 glycoprotein D (gD, SeV-dF/HSV-2-gD) and one encoding HSV-2-infected cell protein 27 (ICP27, SeV-dF/HSV-2-ICP27), based on a replication-defective Sendai virus through reverse genetics, collectively comprising a combinatorial HSV-2 therapeutic vaccine candidate. The immunogenicity and proper immunization procedure for this vaccine were explored in a murine model. The therapeutic effect that helps prevent recurrent HSV-2 disease was evaluated in HSV-2-infected guinea pigs. Results: Both a robust humoral immune response and a cellular immune response, characterized by the neutralizing antibody titer and the IFN-γ level, respectively, were elicited in BALB/c mice. A further study of cellular immunogenicity in mice revealed that T lymphocytes were successfully enhanced with the desirable secretion of several cytokines. In HSV-2-seropositive guinea pigs, vaccination could reduce the severity of HSV-2 in terms of recurrent lesions, duration of recurrent outbreak, and frequency of recurrence by 58.66%, 45.34%, and 45.09%, respectively, while viral shedding was also significantly inhibited in the vaccine-treated group compared to the group treated with phosphate-buffered saline. Conclusions: The replication-defective recombinant Sendai viruses conveying HSV-2-gD and ICP27 proteins showed great immunogenicity and potential for preventing recurrent HSV-2 disease.

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Oral Sex May Serve as Low Mate Value Compensation Among Men: Evidence from a Pre-registered Study

Frankowska,

Szymkow,

Galbarczyk

2024

Arch Sex Behav

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From the evolutionary perspective, maintaining a committed relationship is beneficial for reproductive success but involves risks such as losing a partner or infidelity. People typically prefer partners with similar mate value (MV) to avoid rejection. However, when a mate value discrepancy (MVD) arises, the partner with lower MV might employ mate retention strategies to maintain the relationship. This study investigated whether men with lower MV compared to their female partners used cunnilingus more often and whether this effect was mediated by their motivation to satisfy the partner. Additionally, it tested the moderating role of men’s perceived vulnerability to disease (PVD), predicting that men less concerned about disease would show a stronger link between MVD and cunnilingus frequency, given the health risks associated with oral sex. Data from 540 men in committed heterosexual relationships confirmed that a higher MVD—where the man's MV was lower than his partner's—led to more frequent cunnilingus, and this relationship was mediated by a greater motivation to sexually satisfy the partner. However, the moderating role of PVD was not confirmed. We explore the evolutionary perspective that men may perform oral sex on their partners as a mate retention strategy. This behavior potentially serves as a benefit-provisioning mechanism, compensating for discrepancies in mate value.

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Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications

Cited by 10 publications

References 225 publications

An Epidemiological Study of Cervical Cancer Trends among Women with Human Immunodeficiency Virus

An Epidemiological Study of Cervical Cancer Trends among Women with Human Immunodeficiency Virus

Immunogenicity and Therapeutic Efficacy of a Sendai-Virus-Vectored HSV-2 Vaccine in Mouse and Guinea Pig Models

Oral Sex May Serve as Low Mate Value Compensation Among Men: Evidence from a Pre-registered Study

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