Herpes simplex virus infection in infants: A spectrum of disease

Torphy, Daniel E.; Ray, C. George; McAlister, Robert; Du, Joseph N. H.

doi:10.1016/s0022-3476(70)80480-2

Cited by 45 publications

(10 citation statements)

References 9 publications

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“…Campylobacter-Infektion können sein: Meningitis (l, 32,41,43), Endo-oder Pericarditis (26,29), septische oder reaktive Arthritiden (2, 27, 47), Pneumonien und Lungenabszesse (28,46) sowie Hepatitis (49). Bei diesen schweren Krank• heitsbildern findet sich überwiegend C. fetus ss.…”

Section: Andere Primärmanifestationen Oder Komplikationen Einerunclassified

Campylobacter-Enteritis bei Kleinkindern

Bosch¹,

Sahl²,

Rotthauwe³

1981

Klin Padiatr

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9 children with campylobacter enteritis aging from 3 days to 4 years were seen over a 8-month period. In 2 cases prompt recovery was achieved by erythromycin therapy. In the remaining 7 cases, the course was most often very mild, and symptomatic therapy was sufficient. Epidemiologically, the incidence of campylobacter enteritis is comparable to that of salmonella enteritis. Obviously, birds and poultry, but also dogs, cats, sheep and other domestic and farm animals are important sources of infection. Spread among human beings has also been made probable. The most frequent clinical features are fever, abdominal pain and bloody diarrhoea. Complications are most often associated with subspecies intestinalis whereas infections with subspecies jejuni almost exclusively cause enteritis. C. fetus is usually sensitive to erythromycin, tetracycline and aminoglycosides. The advantage of antibiotic therapy, however, has not yet been established.

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Section: Andere Primärmanifestationen Oder Komplikationen Einerunclassified

Campylobacter-Enteritis bei Kleinkindern

Bosch¹,

Sahl²,

Rotthauwe³

1981

Klin Padiatr

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“…Several reported neonates with disseminated herpes had prominent skin lesions or pneumonitis, suggesting skin and respiratory tract as places of early virus replication. Torphy et al (12) have stressed the wide range of disease which may result from perinatal herpetic infection with HSV type 2, ranging from very mild, self-limited lesions to fatal disease. This spectrum obviously makes it difficult to evaluate the possible efficacy of a prophylactic or therapeutic measure.…”

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confidence: 99%

Inactivation of Herpesvirus hominis Types 1 and 2 by Silver Nitrate In Vitro and In Vivo

Coleman

Wilkie

Levinson

et al. 1973

Antimicrob Agents Chemother

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Herpes simplex virus (HSV) types 1 and 2 (two strains each) were inactivated at different rates in vitro by 40 The present striking increase in the incidence of venereal diseases in the United States has been accompanied by a marked increase in observed genital infections caused by herpesviruses, mostly Herpesvirus hominis (herpes simplex virus [HSVJ) type 2. This rise in genital herpetic infections can be expected to produce an increasing exposure of newborns to the virus during passage through the birth canal, with a possible risk of serious illness (6, 7). The eyes of the neonate are one of the highly susceptible potential sites for infection with herpesviruses. However, immediately after delivery, 1% silver nitrate is instilled into the eyes of all newborns. This "Crede prophylaxis" is highly effective in controlling ocular infection due to gonococci acquired from the mother's genital tract (3). The question arises whether this silver nitrate prophylaxis might also have an effect on herpesvirus eye infection of the neonate acquired during passage through the birth canal. Cell culture. Vero (African green monkey kidney) cells were used in all culture procedures and for the preparation of infective pools of virus. The growth medium was Eagle's minimal essential medium (MEM) with the addition of 5% heat-inactivated fetal calf serum, nonessential amino acids, penicillin (100 units/ml), and streptomycin (100 ug/m4. When confluent monolayers were formed, the growth medium was replaced with maintenance medium (MM) consisting of MEM with 2% heat-inactivated fetal calf serum, nonessential amino acids, penicillin, and streptomycin.For plaque assays, the cells were grown in 16-oz (0.47-liter) prescription bottles. The cell sheets were removed with a mixture of 0.05% pancreatin, 0.05% ethylenediaminetetraacetate, and 0.05% trypsin in phosphate-buffered saline, and were resuspended in growth medium to a concentration of 1.5 million cells/5 ml. This volume was seeded into plastic tissue culture dishes (60 by 15 mm) and incubated at 37 C in 5% CO2 for 2 to 3 days. The medium was removed from confluent monolayers, and plates were inoculated with 0.2 ml of the material to be assayed. After a 2-to 2.5-h adsorption period at on May 12, 2018 by guest http://aac.asm.org/ Downloaded from

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“…Three general patterns of infection due to herpes simplex virus in the neonate have been described: [1][2][3][4] (1) disseminated infection with or without CNS involvement; (This usually involves the liver, adrenal glands, and the lungs. This pattern of infection typically mimics neonatal bacterial sepsis.)…”

Section: Discussionmentioning

confidence: 99%