Herpes simplex virus infection of the hand

Gill, M. John; Ariette, John; Buchan, K.

doi:10.1016/0190-9622(90)70018-d

Cited by 40 publications

(30 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fifty years later, it was recognized that herpetic whitlow was a potential occupational hazard among health care workers [13]. Most cases in the literature reviewed the occupational nature of herpetic whitlow until a review of 79 cases of herpes simplex virus infection of the hand was published by Gill in 1988 [1,14]. Of the 79 cases, only 7 (8%) patients were health care workers, which may represent a greater awareness of herpetic whitlow and improved implementation of infection control precautions [1,14].…”

Section: Discussionmentioning

confidence: 99%

“…The process usually lasts 10À14 days without systemic manifestations [14,15]. Recurrences are usually associated with HSV type 2 infections and account for the majority of cases of HSV infection of the hand [5,14].…”

Section: Discussionmentioning

confidence: 99%

“…Recurrences are usually associated with HSV type 2 infections and account for the majority of cases of HSV infection of the hand [5,14]. Adults aged 20À40 years represent most of the cases of recurrent herpetic whitlow with a 2:1 female to male predominance [14]. However, atypical presentations of HSV infections are not uncommon in immunosuppressed patients [5,8À10].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Multiple herpetic whitlow lesions in a patient with chronic lymphocytic leukemia

Smith¹,

Hallman²,

Pardasani³

et al. 2002

American J Hematol

View full text Add to dashboard Cite

Herpetic whitlow, a herpes simplex virus infection involving the digits, most commonly presents as a vesicular eruption involving a single digit. Diagnosis of herpetic whitlow can usually be made with the history of exposure, the characteristic vesicular eruption, and a positive Tzank smear and/or viral culture. We describe a case of herpetic whitlow in a patient ®nishing 6 cycles of chemotherapy for refractory chronic lymphocytic leukemia that presented with a bilateral, multi-digit, crusted eruption of the hands. This is an illustrative case of an immunocompromised host status altering appearance and course of cutaneous disease such that the history and physical exam alone may not help in diagnosing atypical presentations of herpetic infections. This case underscores the necessity for clinico-histopathologic correlation. Am.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Multiple herpetic whitlow lesions in a patient with chronic lymphocytic leukemia

Smith¹,

Hallman²,

Pardasani³

et al. 2002

American J Hematol

View full text Add to dashboard Cite

show abstract

“…Although the vast majority of recurrent HSV infections of the hand are HSV-2, HSV-1 infection of the hand is occasionally recurrent (3). Studies of recurrent HSV-1 infections of the lips suggest that they, too, respond to such treatment (9).…”

mentioning

confidence: 99%

Oral acyclovir therapy of recurrent herpes simplex virus type 2 infection of the hand

Gill

Bryant

1991

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Acydovir was evaluated as treatment of recurrent herpes simplex virus type 2 infection of the hand in a double-blind, placebo-controed crossover study. In nine fully evaluable patients, oral acyclovir (2 g/day in three doses for 10 days) initiated during the earlist phase of a recurrence reduced the mean durations (± standard deviation) of clinkal symptoms from 10.1 (±3.6) to 3.7 (±3.0) days (P = 0.008), signs from 11.1 (±3.7) to 6.2 (±3.3) days (P = 0.024), and viral positivity from 5.3 (+3.8) to 0.6 (±1.1) days (P = 0.011).Effective treatments for most human herpes simplex virus (HSV) infections have been well documented (7,(9)(10)(11)(12). However, recurrent HSV infection of the band, which can be frequent, painful, and cosmetically unacceptable, has attracted little therapeutic attention (1-3, 5, 6, 8). After an earlier uncontrolled observation, we evaluated in this double-blind, placebo-controlled crossover study the effects of early intervention with oral acyclovir on the durations of symptoms, signs, and virl culture positivity of recurrent HSV type 2 (HSV-2) infection of the hand (4).Fourteen patients (11 males and 3 females) with documented HSV-2 infection of the hand participated in a study that was approved by the University of Calgary Committee on Medical Bioethics. All the patients were between 18 and 50 years old and had between 2 and 12 recurrent infections per year. They were otherwise in good health with no evidence of any underlying immunodeficiency. All the females were using a recognized form of contraception and were not pregnant at the time of treatment.A double-blind, placebo-controlled crossover design was adopted in view of the limited number of eligible patients. Due to uncertainties about the bioavailability of acyclovir at the time of the study design, a high-dose regimen was selected. Active drug or placebo (provided by Burroughs Weilcome, Kirkland, Quebec, Canada) was randomized to either cycle A or B by a computer program. The patients were given written instructions and a bottle of 100 tablets (cycle A). They were advised to take four tablets when prodromal symptoms which they felt likely to result in HSV infection of the hand were first noticed, followed by two doses each of three tablets in a 24-h period. A total of 10 tablets per day in three doses was given for a total of 10 days. The patients were reviewed within 24 h of initiating therapy and then daily until the episode resolved. After the first course of therapy, the patients returned the cycle A bottle and were given a second bottle (cycle B) with identical instructions.The presence and severity of symptoms (pain, swelling, tingling, tenderness, and discomfort) and both local and systemic signs of infection (erythema, papule, vesicle, pustule, scab, lymphangitis, and lymphadenopathy) were recorded at each visit. analyzed by using within-patijnt paired t tests.

show abstract

“…In 1909 Adamson published the first report of herpetic infections of the hand. 2 The term herpetic whitlow was first applied by Stern in his 1959 description of 54 neurosurgical unit nurses with infections of the finger.…”

mentioning

confidence: 99%

Herpetic Whitlow of the Toe

Mohler

2000

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

Herpes simplex virus infection of the hand

Cited by 40 publications

References 32 publications

Multiple herpetic whitlow lesions in a patient with chronic lymphocytic leukemia

Multiple herpetic whitlow lesions in a patient with chronic lymphocytic leukemia

Oral acyclovir therapy of recurrent herpes simplex virus type 2 infection of the hand

Herpetic Whitlow of the Toe

Contact Info

Product

Resources

About