Herpes vegetans of the vulva

Abril‐Pérez, Carlos; Roca-Ginés, Juncal; Sánchez-Arráez, Javier; Torres‐Navarro, Ignacio; Botella‐Estrada, Rafael

doi:10.1016/j.ajog.2021.05.024

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“…Atypical condylomatous or tumor-like fleshy lesions are a rarely observed phenomenon in the immunocompromised population. 1 Such lesions have been documented in the anogenital region 2 , on the face, 3 and surrounding the eyes/eyelids. 4 In the body of literature, this phenomenon has been referred to by many names including (but not limited to): Herpes vegetans, chronic hypertrophic herpes, herpes simplex vegetans, vegetative tumor‐like herpes simplex, and pseudotumoral herpes simplex.…”

Section: Discussionmentioning

confidence: 99%

Herpesvirus Infection Masquerading as a Neoplasm in an HIV-Positive Patient: A Potential Diagnostic Pitfall

Levett¹,

Youngs²,

Hoppenot

et al. 2023

The American Journal of Dermatopathology

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:Herpesvirus infection classically presents as a clustered, vesicular rash over mild erythema. However, unusual presentations may mimic tumors and be a potential pitfall. We describe the case of a 55-year-old HIV positive woman with this unusual manifestation of a common disease which was initially diagnosed as a benign neoplasm. Review of pathology revealed histologic features characteristic of this form of herpesvirus eruption. Awareness of this rare clinical and microscopic presentation is important to guide appropriate use of immunostains, prevent misdiagnosis, and promptly institute of antiviral therapy.

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