Herpes zoster: A possible early clinical sign for development of acquired immunodeficiency syndrome in high-risk individuals

Friedman-Kien, AlvinE.; Lafleur, Francois; Gendler, Ellen C.; Hennessey, N. P.; Montagna, Richard A.; Halbert, Seymour P.; Rubinstein, Pablo; Krasinski, Keith; Zang, Edith; Poiesz, BJ

doi:10.1016/s0190-9622(86)70127-8

Cited by 164 publications

(40 citation statements)

References 19 publications

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“…In one of the studies, 91% of the cases of H zoster referred were seropositive for HIV [23]. Some authors are of the opinion that there is an increased risk of development of AIDS in those patients who develop H zoster [24,25]. Others feel that it is not a reliable sign of profound immunodeficiency as it can occur at any stage of HIV-1 disease [26].…”

Section: Herpes Zoster and Cd4 Countmentioning

confidence: 99%

Orocutaneous Manifestations as Markers of Disease Progression in HIV Infection in Indian Setting

Sawhney¹,

Bhakuni

Gera

2004

Medical Journal Armed Forces India

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Section: Herpes Zoster and Cd4 Countmentioning

confidence: 99%

Orocutaneous Manifestations as Markers of Disease Progression in HIV Infection in Indian Setting

Sawhney¹,

Bhakuni

Gera

2004

Medical Journal Armed Forces India

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“…[5]. A eight year follow up study of herpes zoster in HIV infected patients is presented in this study.…”

Section: ][3][4]mentioning

confidence: 99%

Study on Herpes Zoster Conducted in HIV/AIDS Albanian Adults

2015

IJSR

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Herpes zoster is currently recognized as one of the major opportunistic infections of HIV / AIDS.It may appear at the first time of HIV infection or AIDS, and in the case of immune recovery after the initiation of ART. We studied 481 cases with HIV / AIDS registered in Infectious diseases services and out patient clinic of HIV / AIDS, of UHC "Mother Theresa". 61 of them resulted Hepes zoster .We analyzed the time of occurrence of Zoster in these subjects, the CD4 + level at the time of diagnosis, localization of vesicles, the type and density of them, his appearance at the time of immune recovery. We analyzed also some of the epidemiological aspects and co-infections manifested at the same time in these subjects. From them 63.9% were male, age group 31-40 years old and 41-50 years old respectively resulted affected 31.14% and 34.45% ,was encountered 24 types concomitant opportunistic infections; In 31.1% of cases CD4 + was seen in limits 100 cel/mm3 -250 cel / mm3. In 40.32% predominated thoracic localization of vesicular elements followed by 19.35% from that thoraco-lumbar. Ulcero hemorrhagic forms were encountered in 12.16%. Morality occurred in 6.55%

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“…However, these further amino acid substitutions did result in variations in the degree of resistance or hypersusceptibility to ACVTP and phosphonoacetate, respectively. When they were used to evaluate the novel cyclobutyl nucleoside analog 9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine triphosphate and the nucleotide analog 9-[2-(phosphonomethoxy)-ethyl]guanine diphosphate, all of the altered HSV pols, as well as the wild-type HSV pol, retained identical susceptibilities (92 (21), and it was recognized that herpes zoster could be an early clinical sign of the development of AIDS (52).…”

Section: Introductionmentioning

confidence: 99%

"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs

Field¹,

Biron²

1994

Clin Microbiol Rev

171

109

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In the past 4 years, interest in drug-resistant herpesviruses has evolved from the realm of academic laboratory studies to that of great clinical importance. Recurrent and persistent infections due to the herpes simplex viruses, varicella-zoster virus, and human cytomegalovirus have been an unwelcome consequence of immunosuppression in graft recipients, cancer patients, and those suffering from AIDS. Treatment of these infections with the available antiviral drugs, such as acyclovir, ganciclovir, and foscarnet, has resulted in both clinical benefit and the emergence of drug-resistant variants. In addition, the role of Epstein-Barr virus is being clarified for an array of disease syndromes, and therapeutic approaches are beginning to emerge. In the present review, the emergence and clinical importance of drug resistance among the herpesviruses have been explored. Furthermore, particular attention has been focused on our understanding of the mechanisms of drug resistance and how that understanding will guide us in the development of more effective antiviral drugs and drug usage.

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Herpes zoster: A possible early clinical sign for development of acquired immunodeficiency syndrome in high-risk individuals

Cited by 164 publications

References 19 publications

Orocutaneous Manifestations as Markers of Disease Progression in HIV Infection in Indian Setting

Orocutaneous Manifestations as Markers of Disease Progression in HIV Infection in Indian Setting

Study on Herpes Zoster Conducted in HIV/AIDS Albanian Adults

"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs

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