Herpes Zoster and Subsequent Cancer Risk: A Nationwide Population-Based Cohort Study in Korea

Kim, Miri; Han, Kyungdo; Yoo, Seung Ah; Lee, Ji Hyun

doi:10.1159/000505911

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…This may be the result of ours being a matched control study (by age, gender, and CCI) rather than a conventional cohort study or may actually reflect a true trend in the Korean race that is different from other races. Recently, Kim et al reported that the incidence of liver, esophagus, and pharyngeal cancers is lower in the HZ group [ 40 ], and this result is consistent with our findings. In addition, the prevalence of digestive system cancers, such as stomach and esophageal cancers, differs significantly between the West and East, and this is known to be related to various factors, including diet and lifestyle [ 41 , 42 ].…”

Section: Discussionsupporting

confidence: 93%

The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study

et al. 2021

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Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer risk. Methods: Of 134,454 patients diagnosed with HZ between 2002 and 2015, 81,993 HZ patients were matched 1:1 with non-HZ individuals by age, sex, and Charlson comorbidity index. Both groups were examined at 1, 3, and 5 years for cancer diagnosis. A Cox proportional hazard regression model was used to estimate cancer risk in both groups. The postherpetic neuralgia (PHN) and non-HZ groups were compared for specific cancer risk. Results: The HZ group showed a slightly decreased overall cancer risk compared with the non-HZ group (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.90–0.97, p = 0.002). The HRs for specific cancer risk were 0.41 (95% CI, 0.33–0.50, p < 0.001); 0.86 (95% CI, 0.81–0.91, p < 0.001); 0.87 (95% CI, 0.78–0.97, p = 0.014); 0.80 (95% CI 0.73–0.87, p < 0.001); 1.20 (95% CI, 1.07–1.34, p = 0.001); and 1.66 (95% CI, 1.35–2.03, p < 0.001) for cancers of the lips, mouth, and pharynx; digestive system; respiratory system; unknown secondary and unspecified sites; thyroid and endocrine glands; and lymphoid and hematopoietic systems, respectively. The HZ with PHN group showed higher HR for specific cancer risk, such as lymphoid and hematopoietic systems (95% CI, 1.27–2.39, p < 0.001). Conclusion: HZ was associated with increased or decreased incidence of specific cancers. PHN further increased the risk of developing certain cancers in HZ patients.

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Section: Discussionsupporting

confidence: 93%

The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study

et al. 2021

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“…The relationship between HZ and cancer has been drawing more and more attention from clinical and scientific researchers [ 22 , 23 ]. Qian et al reported a cohort study indicating that cancer was associated with an increased risk of developing HZ (adjusted hazard ratio [HR] 1.41; 95% CI 1.32–1.52), which was partially compatible with a meta-analysis showing a positive association between HZ and occult cancer [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Poor Pain Control in Zoster-Associated Pain: A Retrospective Study

et al. 2022

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Introduction:The objective was to investigate the risk factors for poor pain control in patients with herpes zoster (HZ)-associated neuropathic pain treated with drugs combined with nerve block therapy. Neuropathic pain commonly follows HZ. Nerve block therapy is the most commonly used clinical treatment for such pain, combining anti-inflammation and analgesia to prevent peripheral sensitization of nerve. Methods: Using clinical practice data from a cohort study at our research center, we established a multivariate logistic regression model to investigate potential risk factors for poor control of zoster-associated pain (ZAP) treated with drugs plus nerve block therapy, including demographic characteristics, complications, laboratory tests, and characteristics of HZ attacks. Results: Of the 429 patients with ZAP who received drugs plus nerve block therapy, 95 (22.14%) had poor pain control after treatment. The risk of poor pain control was closely related to presence of cancer (odds ratio (OR) 4.173, 95% confidence interval (CI) 1.342-12.970), numerical rating scale score on admission (OR 1.929, 95% CI 1.528-2.434), and red blood cell count (OR 0.560, 95% CI 0.328-0.954). Area under the receiver operator characteristic curve was 0.730. Goodness of fit (Hosmer-Lemeshow) was 0.874. Conclusions: The risk of poor pain control in patients with ZAP increased as a result of certain patient characteristics and complications, especially severe pain before treatment and cancer.

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“…The herpes zoster group exhibited a significantly increased risk of hematologic malignancies, including multiple myeloma (HR 1.63, 95% CI 1.37–1.95), leukemia (HR 1.20, 1.03–1.39), and lymphoma (HR 1.15, 11.02–1.30), compared with the non-herpes zoster group [ 66 ]. Conversely, the risk of liver (HR 0.87, 95% CI 0.82–0.93) and larynx (HR 0.73, 0.58–0.92) cancers was significantly decreased in the herpes zoster group compared to the non-herpes zoster group.…”

Section: Postherpetic Complicationsmentioning

confidence: 99%

Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination

Yamaoka-Tojo,

Tojo

2024

Vaccines

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Herpes zoster, induced by the reactivation of the varicella-zoster virus (VZV), is a unilaterally distributed vesicular rash that can cause multiple complications. VZV not only causes neurological problems, including postherpetic neuralgia and ocular zoster, but also causes inflammatory vasculopathy and increases the incidence of hemorrhagic or ischemic complications. Therefore, understanding the association between the development of herpes zoster and the subsequent occurrence of acute stroke or cardiovascular diseases, including myocardial infarction and heart failure, is of great interest. Conversely, many risk factors are involved in the development of herpes zoster. Recently, it has become clear that aging, insufficient immune function, and diseases related to lifestyle habits (for example, stroke and cardiovascular disease), can trigger the onset of herpes zoster. Preventing the onset of herpes zoster, which substantially reduces quality of life, will lead to lower medical costs for countries and extend healthy life expectancy for general populations. Thus, because herpes zoster is a vaccine-preventable disease, active vaccination is recommended for high-risk groups. This review summarizes the association between herpes zoster and cardiovascular disease and vaccination against herpes zoster as a useful disease management and prevention measure for cardiovascular disease.

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Herpes Zoster and Subsequent Cancer Risk: A Nationwide Population-Based Cohort Study in Korea

Cited by 10 publications

References 16 publications

The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study

The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study

Risk Factors for Poor Pain Control in Zoster-Associated Pain: A Retrospective Study

Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination

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