2021
DOI: 10.1111/jocd.14679
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Herpes zoster involving trigeminal nerve: An early cutaneous predictor of COVID‐19—a case series and review of the literature

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“…10 COVID-19 has been shown to be associated with a persistent decrease in lymphocytes during the disease, 10 and it is thought that the lymphocyte reduction caused by COVID-19, especially CD3+ CD8+ lymphocytes, may activate latent VZV. [11][12][13] All 10 patients in one case series 14 developed HZ within 3 weeks of being diagnosed with COVID-19 infection, which suggested the important role of COVID-19 in the occurrence of HZ. In one study, the results indicated that the risk of HZ is significantly increased in patients over 50 years of age diagnosed with COVID-19, and COVID-19 infection may trigger VZV reactivation.…”
Section: Discussionmentioning
confidence: 96%
“…10 COVID-19 has been shown to be associated with a persistent decrease in lymphocytes during the disease, 10 and it is thought that the lymphocyte reduction caused by COVID-19, especially CD3+ CD8+ lymphocytes, may activate latent VZV. [11][12][13] All 10 patients in one case series 14 developed HZ within 3 weeks of being diagnosed with COVID-19 infection, which suggested the important role of COVID-19 in the occurrence of HZ. In one study, the results indicated that the risk of HZ is significantly increased in patients over 50 years of age diagnosed with COVID-19, and COVID-19 infection may trigger VZV reactivation.…”
Section: Discussionmentioning
confidence: 96%