Herpesviral–bacterial interrelationships in aggressive periodontitis

Saygun, Işıl; Kubar, Ayhan; Özdemir, Atilla; Yapar, Mehmet; Slots, Jørgen

doi:10.1111/j.1600-0765.2004.00728.x

Cited by 102 publications

(145 citation statements)

References 26 publications

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“…3 The herpesviruses, especially Epstein-Barr virus (EBV) and the human cytomegalovirus (HCMV) have been detected at destructive periodontitis and sites with active periodontal disease. 4 The higher prevalence of these viruses in combination with the anaerobic bacteria and the host immune factors may aggravate the progress of the disease. 5 There has been conflicting evidence found in a few studies from around the globe which suggest that the EBV and the HCMV are present at fewer periodontal sites than considered otherwise.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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Objective: The identification of new uncultured species and viruses supports the possibility of combination of the herpesvirus-bacterial periodontal infection for periodontitis. The paucity of data and studies with larger sample size in Indian subjects provides an unclear picture of the presence of the herpesvirus in this population. Materials and methods:This was a cross-sectional study consisting of 100 each in the healthy group and chronic periodontitis (CP) group. The subgingival plaque was collected and polymerase chain reaction was performed post deoxyribonucleic acid (DNA) extraction by using specific primers for human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). The data were analyzed using Fisher's exact test, Mann-Whitney U test and Spearman's coefficient correlation.Results: Human cytomegalovirus and EBV viruses were significantly higher in the CP group as compare to the healthy group. A higher percentage of those with CMV positive had EBV also positive (28.3%) compared to only 9.1% of CMV negative being EBV positive in the CP group. When both the healthy and CP group in total was compared, there was a significant correlation with all clinical parameters. Conclusion:Both the viruses dominated in disease as compared to health were similar to the earlier findings. The CP group had higher pocket depth and clinical attachment loss in the virus positive subjects. These findings could suggest that 91-9620127630, e-mail: drvinayakjoshi@gmail.com virus serves as a prelude to the disease and the combination of the two viruses could play a role in the pathogenesis. Prevalence of Herpesvirus and Correlation with Clinical

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Section: Introductionmentioning

confidence: 99%

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

show abstract

“…In other research, it has been associated with aggressive and chronic periodontitis (Bilichodmath et al, 2009;Botero et al, 2007;Contreras et al, 2000;Ling et al, 2004, Yapar et al, 2003Saygun et al, 2004). We found that 8% of the individuals in our study from northeastern Mexico suffering from chronic periodontitis had HSV-1 present in the periodontal pockets.…”

Section: Discussionmentioning

confidence: 59%

“…It is important to consider the composition of the subgingival microflora since this varies significantly when the periodontium is pathologically affected. Previous research on this disorder has focused on putative periodontal bacteria and their products (Saygun et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Identification of Herpes virus in patients with chronic periodontitis from Northeastern Mexico

Mauricio¹,

Ernesto²,

Rosa³

et al. 2013

Afr. J. Microbiol. Res.

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Periodontitis is an inflammatory process that occurs in the tissues surrounding the teeth. It is caused by microorganisms and groups of microorganisms and results in loss of periodontal ligament and alveolar bone. Herpes virus has emerged as a putative pathogen in periodontal disease. Periodontal disease was demonstrated in 50 patients by careful probing of pockets and completion of a medical record. Three saliva samples were collected in individuals with deep pockets. Samples were obtained with a sterile swab and placed in 10% glucose solution for storage at -80°C. DNA purification and PCR, in addition to electrophoresis, were performed. Of the 50 samples processed, two were positive for HSV-1 and two for HSV-2. Three were from women with mild, moderate, and severe chronic periodontitis, respectively, and one (HSV-1) from a man with mild chronic periodontitis. Due to the low prevalence of herpes simplex virus in periodontal pockets, it was not possible to determine its role in the progression of periodontitis.

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“…Research during the past 15 years has implied that herpesviruses are involved in the etiopathogeny of destructive periodontal disease (Saygun et al, 2004;Slots et al, 2004). Hopefully, increased knowledge of the immunovirology of cytomegalovirus and other herpes viruses in periodontitis may lead to a greater understanding of periodontal host responses and to more effective preventive and therapeutic interventions, including future vaccination against periodontopathic Herpes viruses.…”

Section: Treatmentmentioning

confidence: 99%