Herpesvirus Antibodies and Vascular Complications in Essential Hypertension

Kristensen, Bent Bruun; Andersen, Paul; Vestergaard, Bent Faber; Andersen, Hans M. K.

doi:10.1111/j.0954-6820.1982.tb03232.x

Cited by 11 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with the findings of the mouse trial, HCMV might infect different types of human cells and induce expression of cytokines such as (interleukin‐2, interleukin‐6, tumor necrosis factor, and monocyte chemoattractant protein‐1) [Bentz et al, ; Botero et al, ; Zheng et al, ]. In addition, HCMV infection is a risk factor for increased arterial blood pressure and aortic atherosclerosis [Kristensen et al, ; Roberts et al, ]. It is here concluded that the results of animal model and cell‐based studies are consistent with those of epidemiological studies showing that HCMV infection is a risk factor for human EH.…”

Section: Discussionsupporting

confidence: 81%

Is human cytomegalovirus infection associated with essential hypertension? A meta‐analysis of 11,878 participants

Wang

Peng

et al. 2015

Journal of Medical Virology

View full text Add to dashboard Cite

Human cytomegalovirus (HCMV) has been reported to be highly expressed in essential hypertension (EH), and it has been proposed that HCMV infection may contribute to EH development. However, different studies showed opposite results. The present meta-analysis was performed to investigate the association between HCMV infection and the risk of EH. All relevant literature from 1980 to 2015 was extracted from six electronic databases. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of the association of HCMV infection and risk of EH. Sensitivity analysis and examination for bias were conducted to evaluate cumulative evidence of the association. The random-effect model using the Mantel-Haenszel method was used to give the individual effect-size estimates. Of the 11,878 participants included in this study, there were 3,864 EH patients and 8,014 control subjects. Meta-analysis of nine studies performed in a random-effect model found that EH patients had a higher risk of HCMV infection than normal control subjects (OR = 1.47, 95%CI: 1.13-1.90, P = 0.004; heterogeneity: I(2) = 66%, P = 0.002). Sensitivity analysis and bias examination showed the overall quality and consistency of the studies to be acceptable. For subgroup analysis, studies of Chinese populations were selected for further analysis. There was a significant association between HCMV infection and EH among Chinese patients (OR = 2.18, 95%CI:1.43-3.31, P = 0.0003) but not among other ethnic groups (OR = 1.11, 95%CI:0.95-1.31, P = 0.19). These findings provide quantitative support for the association between HCMV infection and high risk of EH in individuals of Chinese ethnicity.

show abstract

Section: Discussionsupporting

confidence: 81%

Is human cytomegalovirus infection associated with essential hypertension? A meta‐analysis of 11,878 participants

Wang

Peng

et al. 2015

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…C. pneumoniae seropositivity has also been linked to the so‐called metabolic syndrome and dyslipidemia (26, 27, 28, 29) and to type 2 diabetes (30). Type 2 diabetes and hypertension have also been reported to be linked to herpes simplex virus (HSV) type 1 IgG (31, 32), HSV‐2 IgG seropositivity (33), and cytomegalovirus (34).…”

Section: Introductionmentioning

confidence: 99%

Burden of Infection and Fat Mass in Healthy Middle‐aged Men

Fernández-Real

Ferri

Vendrell

et al. 2007

Obesity

View full text Add to dashboard Cite

FERNÁ NDEZ-REAL, JOSÉ -MANUEL, MARIA-JOSÉ FERRI, JOAN VENDRELL, AND WIFREDO RICART. Burden of infection and fat mass in healthy middle-aged men. Obesity. 2007;15:245-252. Objective: Our aim was to study the effect of exposure to four infections on fat mass. Research Methods and Procedures: This was a crosssectional study of healthy middle-aged men from the general population (n ϭ 74). Each study subject's serum was tested for specific IgG class antibodies against herpes simplex virus (HSV)-1, HSV-2, enteroviruses, and Chlamydia pneumoniae through the use of quantitative in vitro enzymelinked immunosorbent assays (ELISAs). A total pathogen burden score based on these seropositivities [Quantitative Seropositivity Index (QSI)] was constructed. Fat mass was measured by bioelectrical impedance. Results: We observed significant relationships between the HSV-1 titer and fat mass and percentage fat mass. The associations were stronger when considering the infection burden. The QSI was significantly associated with fat mass (r ϭ 0.30, p ϭ 0.009) and percentage fat mass (r ϭ 0.27, p ϭ 0.01). Those subjects in the highest tertile of fat mass showed significantly higher QSI (259.5 Ϯ 74.1 vs. 206.9 Ϯ 78.2, p ϭ 0.007). In subjects that were seropositive for Enteroviruses, the relationship between the QSI and fat mass was strengthened (r ϭ 0.51, p ϭ 0.02). In a multivariate regression analysis, the QSI, independently of age and C-reactive protein, contributed to 9% of fat mass variance. Discussion: Pathogen burden showed an association with fat mass. Subjects with increased fat mass could be more susceptible to developing multiple infections resulting in a chronic low-grade inflammation. We can not exclude the possibility that exposure to multiple infections leads to increased fat mass.

show abstract

Cytomegalovirus and Cardiovascular Disease: A Hypothetical Role for Viral G-Protein-Coupled Receptors in Hypertension

Bomfim

Priviero

Poole

et al. 2023

American Journal of Hypertension

View full text Add to dashboard Cite

Cytomegalovirus (CMV) is a member of the β- herpesviruses and is ubiquitous, infecting 50-99% of the human population depending on ethnic and socioeconomic conditions. CMV establishes lifelong, latent infections in their host. Spontaneous reactivation of CMV is usually asymptomatic, but reactivation events in immunocompromised or immunosuppressed individuals can lead to severe morbidity and mortality. Moreover, herpesvirus infections have been associated with several cardiovascular and post-transplant diseases (stroke, atherosclerosis, post-transplant vasculopathy and hypertension). Herpesviruses, including CMV, encode viral G protein–coupled receptors (vGPCRs) that alter the host cell by hijacking signaling pathways that play important roles in the viral life cycle and these cardiovascular diseases. In this brief review, we discuss the pharmacology and signaling properties of these vGPCRs, and their contribution to hypertension. Overall, these vGPCRs can be considered attractive targets moving forward in the development of novel hypertensive therapies.

show abstract

Herpesvirus Antibodies and Vascular Complications in Essential Hypertension

Cited by 11 publications

References 14 publications

Is human cytomegalovirus infection associated with essential hypertension? A meta‐analysis of 11,878 participants

Is human cytomegalovirus infection associated with essential hypertension? A meta‐analysis of 11,878 participants

Burden of Infection and Fat Mass in Healthy Middle‐aged Men

Cytomegalovirus and Cardiovascular Disease: A Hypothetical Role for Viral G-Protein-Coupled Receptors in Hypertension

Contact Info

Product

Resources

About