Herpesviruses in Abscesses and Cellulitis of Endodontic Origin

Chen, Vicky; Chen, Yanwen; Li, Hong; Kent, Karla S.; Baumgartner, J. Craig; Machida, Curtis A.

doi:10.1016/j.joen.2008.11.018

Cited by 48 publications

(64 citation statements)

References 30 publications

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“…We used same sampling techniques applied by Chen et al [1]. This may be the reason of our results consistency with the findings of Chen et al [1], who found HCMV and EBV in 29 and 6.5% of abscess specimens, respectively.…”

Section: Discussionsupporting

confidence: 87%

“…The discrepancies in the findings among our study and the three studies mentioned above might arise for several reasons, including differences in the primers used, methods used for DNA extraction, and host and environmental factors such as genetic background, ethnicity, and socioeconomic status [8,[20][21][22][23]. We used same sampling techniques applied by Chen et al [1]. This may be the reason of our results consistency with the findings of Chen et al [1], who found HCMV and EBV in 29 and 6.5% of abscess specimens, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Herpesviral and "Red Complex" Bacterial Analysis of Acute Apical Abscesses many different epithelial cells, endothelial cells, smooth muscle cells, mesenchymal cells, hepatocytes, granulocytes, and monocyte-derived macrophages and resides in the bone marrow myeloid progenitor cells during latency [1,9,12].…”

Section: Research Articlementioning

confidence: 99%

“…An acute apical abscess is an inflammatory disease of endodontic origin caused by a mixed bacterial infection, dominated by anaerobic species and characterised by rapid onset, spontaneous pain, tenderness of the tooth to pressure, purulent fluid formation, and associated swelling [1,2]. The microbial diversity in different forms of periapical pathology, including acute apical abscesses, has traditionally been assessed using anaerobic cultures and cultureindependent molecular methods.…”

Section: Introductionmentioning

confidence: 99%

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Herpesviral and “Red Complex” Bacterial Analysis of Acute Apical Abscesses

Ozbek¹

2015

J Dent Probl Solut

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Introduction: To investigate the possible association between presence of Epstein-Barr virus, human cytomegalovirus and three endodontic bacterial pathogens (Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia) "red complex" in samples from patients with acute apical abscesses using real-time PCR.Methods: Periapical samples were collected from 18 acute apical abscess specimens and 6 control samples. The apical area of each study tooth was examined in periapical radiographs obtained using a long cone paralleling technique. The study included only single-rooted teeth that had carious lesions, necrotic pulps, and radiographic evidence of periradicular bone loss. No apparent communication from the abscess to the oral cavity or skin surface was observed. DNA extracts from purulent exudate aspirates of acute apical abscess and six control samples were evaluated for the presence of microbial and viral loads using real-time polymerase chain reaction (PCR) following the kit protocols recommended by the manufacturers. The chi squared test was used for statistical analysis.Results: HCMV, EBV, T. denticola, P. gingivalis, and T. forsythia were detected in 16.7 %, 5.6 %, 44.4 %, 27.7 %, and 22.2 % of the samples, respectively. As for the healthy pulps used as noninflamed controls, no control specimens contained bacterial or viral DNA. The pair HCMV/ T. denticola and HCMV/ T. forsythia was detected in one case. The association between HCMV, T denticola and T. forsythia was not statistically significant. Conclusion:Within the limitations of the present study, our PCR based findings revealed that in "red complex" bacteria, T. denticola and T. forsythia tended to occur in co-infection with HCMV.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Research Articlementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Herpesviral and “Red Complex” Bacterial Analysis of Acute Apical Abscesses

Ozbek¹

2015

J Dent Probl Solut

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“…an increase in B-cell secretion of the receptor activator NF-κB ligand and the development of the CP pattern [23] occur.…”

Section: Thus After Inoculation Of a Actinomycetemcomitans And Specmentioning

confidence: 99%

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Batyrbekova¹

2017

AJP

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Pyoinflammatory diseases of maxillofacial area (MFA) are one of the most serious problems of maxillofacial surgery. The high medical and social significance of these diseases are due to their frequent occurrence in persons of working age and the risk of life-threatening complications: Bleeding from the great vessel, brain abscess, the spread of infection into the deep cellular spatium of the collum. In more than 1/3 of all patients, pyogenic lesions of MFA develop on the background of secondary immunodeficiency, accompanied by impaired regulation of the secretion of pro-inflammatory cytokines, and predisposing to prolonged smoldering flow or, on the contrary, rapid spread of inflammation with extensive tissue damage. This fact determines the importance of developing integrated approaches to diagnostics and treatment. The aim of the study is to generalize modern ideas about causative agents and their effect on the features of the inflammatory diseases of the MFA. We systematized and analyzed contemporary works of Russian and foreign authors on the study of the effects of causative agents of bacterial and viral nature and characteristic changes in the immune status. The modern data on the role of microbial factors in the development and maintenance of local and systemic immunological status disorders in case of inflammatory disease of MFA are presented, the impact on the development of bacterial and viral microflora diseases is given, with special attention paid to immunomodulatory effects of causative agents. The factors of pathogens influence most frequently associated with inflammatory diseases of theMFA and collum, as well as the relationship of individual microorganisms with the clinical manifestations of this pathology type and the detection of the pathogenetic role of immune disorders, allow to conduct studies on the formation of optimal correction schemes for each patient (personified) depending on the features of the course of the disease.

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Root Canal Infection and Endodontic Apical Disease

Cohenca

Amaro

2014

Disinfection of Root Canal Systems

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Herpesviruses in Abscesses and Cellulitis of Endodontic Origin

Cited by 48 publications

References 30 publications

Herpesviral and “Red Complex” Bacterial Analysis of Acute Apical Abscesses

Herpesviral and “Red Complex” Bacterial Analysis of Acute Apical Abscesses

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Root Canal Infection and Endodontic Apical Disease

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