Herstellung und antivirale Wirksamkeit von Polyacrylsäure und Polymethacrylsäure

Abstract

The antiviral activity of a number of fractions of poly(acry1ic acid)s and poly(methacry1ic acid)s with different tacticities, different molecular weights and molecular weight distributions has been investigated. Isotactic poly(acry1ic acid)s are essentially more antiviral active in the whole area of efficacy than the atactic ones. Independent of the tacticity poly(acry1ic acid)s with molecular weights smaller than 5000 show no significant effects, polymers with molecular weights greater than 25000 are toxic in the used doses. The optimum of efficacy is between 6000 and 15000. Isotactic poly(acry1ic acid)s with narrow molecular weight distributions are more active than those with broad distributions. The atactic poly(acry1ic acid)s with lower efficacy do not show this relationship. Atactic poly(methacry1ic acid)s are not antiviral active in vivo compared with untreated controls. Isotactic ones have a just detectable efficacy which is essentially lower than the activity of the atactic poly(acry1ic acid)s.

Syntheses and antitumor activities of polymers containing amino acid and 5-fluorouracil moieties

“…The M n s were in the 4,600 -10,700 range, and polydispersity indices (M w /M n ) fell between 1.5 and 2.7. Ottenbrite et al 42 reported that optimum antitumor activity can be obtained with average molecular weights ranging from 10,000 to 30,000, depending on the polymer. The average molecular weights of the synthesized polymers were in a reasonable range to exhibit the antitumor activity.…”

Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment

“…Indeed, even fully synthetic macromolecules, which do not contain any peptide, nucleotide, or saccharide units, were recognized for their therapeutic activity already in 70s [ 38,39 ] and from this time polymer materials were recognized also as potential drug‐free therapeutics for overcoming multidrug resistance [ 40 ] or in the antibacterial treatment. [ 41 ] In the following chapters, the various approaches are described in detail and the macromolecular systems acting as therapeutics themselves together with macromolecules decorated by the biorecognition ligands are reviewed thoroughly.…”

Macromolecular therapeutics

“…Polyelectrolytes stimulate interferon production in cells and living organisms [3,4]. Stereochemistry may have an impact on activity: isotactic poly(acrylic acid) possesses antiviral properties whereas atactic poly(acrylic acid) does not [5]. …”