HES1 as an Independent Prognostic Marker in Esophageal Squamous Cell Carcinoma

Taleb, Shaghayegh; Abbaszadegan, Mohammad Reza; Moghbeli, Meysam; Roudbari, Nasim Hayati; Forghanifard, Mohammad Mahdi

doi:10.1007/s12029-014-9648-1

Cited by 25 publications

(9 citation statements)

References 40 publications

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“…The used thermal profile for genes amplification was consisted of initial denaturing at 95°C for 10 min followed by 40 cycles of 15 seconds at 95°C, 30 seconds at 57°C and 45 seconds at 72°C. Glyceraldehyde 3‐phosphate dehydrogenase was used as an internal control for data normalization via the comparative threshold cycle method . For measuring the efficiency of PCR, the related standard curve was generated by using serial dilution of cDNA.…”

Section: Methodsmentioning

confidence: 99%

Correlation between SALL4 stemness marker and bone morphogenetic protein signaling genes in esophageal squamous cell carcinoma

Assarnia

Khales

Forghanifard

2018

J Biochem & Molecular Tox

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SALL4, as a stemness marker, plays a key role in the maintenance of pluripotency and self‐renewal of cancer stem cells. To elucidate probable linkage between SALL4 stemness marker and bone morphogenetic protein (BMP) cell signaling pathway, we aimed to analyze the expression levels of the related genes in esophageal squamous cell carcinoma (ESCC) patients. Tumoral and corresponding margin normal tissues from 50 treatment‐naive ESCC patients were subjected for expression analysis using relative comparative real‐time reverse transcription polymerase chain reaction. There were significant correlations between SALL4 mRNA and BMP signaling target genes expression including SIZN1, VENTX, and DIDO1 (P < 0.01). Tight associations of gene expression were observed in primary stages of tumor progression (stages I/II), and the invaded tumors to the adventitia (T3/T4). Furthermore, significant correlations between the expression of BMP signaling target genes were observed (P < 0.01). SALL4 may play role in tumorigenesis and tumor cell invasiveness of ESCC through correlation with BMP signaling genes.

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Section: Methodsmentioning

confidence: 99%

Correlation between SALL4 stemness marker and bone morphogenetic protein signaling genes in esophageal squamous cell carcinoma

Assarnia

Khales

Forghanifard

2018

J Biochem & Molecular Tox

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“…In another study, mRNA levels of HEY1 (a target gene of Notch/CSL/MAML‐mediated signaling pathway) were found to be underexpressed in a subset (26%) of ESCC sample, which was significantly correlated with tumor depth of invasion 59.…”

Section: Notch Signaling In Head and Neck Squamous Cell Carcinoma (Hnmentioning

confidence: 95%

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

et al. 2016

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The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro‐oncogenic, typically depending on the cellular context. Squamous cell carcinoma (SCC) is a cancer of the squamous cell, which can occur in diverse human tissues. SCCs are one of the most frequent human malignancies for which the pathologic mechanisms remain elusive. Recent genomic analysis of diverse SCCs identified marked levels of mutations in NOTCH1, implicating Notch signaling pathways in the pathogenesis of SCCs. In this review, evidences highlighting NOTCH's role in different types of SCCs are summarized. Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH1 gene mutations identified from diverse SCCs are analyzed, emphasizing loss of function of Notch in these cancers. Finally, we discuss the convergent view on an intriguing possibility that Notch may function as tumor suppressor in SCCs across different tissues. These mechanistic insights into Notch signaling pathways will help to guide the research of SCCs and development of therapeutic strategies for these cancers.

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“…All of the clinicopathological features (sex, age, tumor size and grade, histopathological stage, etc.) of the patients are mentioned in our recent studies (Table 1) [22,20,23,21,24].…”

Section: Study Populationmentioning

confidence: 99%

Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

Moghbeli

Forghanifard

Sadrizadeh

et al. 2015

J Gastrointest Canc

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HES1 as an Independent Prognostic Marker in Esophageal Squamous Cell Carcinoma

Abstract: Although we have not observed any significant correlation between the HES1 expression and notch activation in ESCC, this study is the first report that elucidated the HES1 underexpression in ESCC and revealed its correlation with the invasiveness of ESCC.

Cited by 25 publications

References 40 publications

Correlation between SALL4 stemness marker and bone morphogenetic protein signaling genes in esophageal squamous cell carcinoma

Correlation between SALL4 stemness marker and bone morphogenetic protein signaling genes in esophageal squamous cell carcinoma

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

Role of Msi1 and MAML1 in Regulation of Notch Signaling Pathway in Patients with Esophageal Squamous Cell Carcinoma

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