2023
DOI: 10.1002/advs.202300470
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hESC‐Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine

Xiao‐Ling Luo,
Yun Jiang,
Qiang Li
et al.

Abstract: Myocardial infarction (MI) causes excessive damage to the myocardium, including the epicardium. However, whether pluripotent stem cell‐derived epicardial cells (EPs) can be a therapeutic approach for infarcted hearts remains unclear. Here, the authors report that intramyocardial injection of human embryonic stem cell‐derived EPs (hEPs) at the acute phase of MI ameliorates functional worsening and scar formation in mouse hearts, concomitantly with enhanced cardiomyocyte survival, angiogenesis, and lymphangiogen… Show more

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