Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

Yang, Yong; Wolfram, Joy; Boom, Kathryn; Fang, Xiaohong; Shen, Haifa; Ferrari, Mauro

doi:10.1002/cbf.2905

Cited by 104 publications

(62 citation statements)

References 46 publications

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“…Indeed, harmful solvents have been used extensively in vitro and in vivo to permit the delivery of non-water-soluble drugs. For instance, dimethyl sulfoxide (DMSO) is usually the first agent of choice for cell culture [34, 35]. However, DMSO has displayed toxicity in multiple studies [36–39].…”

Section: Reduction Of Drug Toxicity Through Nanomedicinementioning

confidence: 99%

Safety of Nanoparticles in Medicine

Wolfram¹,

Zhu

Yang

et al. 2015

CDT

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441

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Nanomedicine involves the use of nanoparticles for therapeutic and diagnostic purposes. During the past two decades, a growing number of nanomedicines have received regulatory approval and many more show promise for future clinical translation. In this context, it is important to evaluate the safety of nanoparticles in order to achieve biocompatibility and desired activity. However, it is unwarranted to make generalized statements regarding the safety of nanoparticles, since the field of nanomedicine comprises a multitude of different manufactured nanoparticles made from various materials. Indeed, several nanotherapeutics that are currently approved, such as Doxil and Abraxane, exhibit fewer side effects than their small molecule counterparts, while other nanoparticles (e.g. metallic and carbon-based particles) tend to display toxicity. However, the hazardous nature of certain nanomedicines could be exploited for the ablation of diseased tissue, if selective targeting can be achieved. This review discusses the mechanisms for molecular, cellular, organ, and immune system toxicity, which can be observed with a subset of nanoparticles. Strategies for improving the safety of nanoparticles by surface modification and pretreatment with immunomodulators are also discussed. Additionally, important considerations for nanoparticle safety assessment are reviewed. In regards to clinical application, stricter regulations for the approval of nanomedicines might not be required. Rather, safety evaluation assays should be adjusted to be more appropriate for engineered nanoparticles.

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Section: Reduction Of Drug Toxicity Through Nanomedicinementioning

confidence: 99%

Safety of Nanoparticles in Medicine

Wolfram¹,

Zhu

Yang

et al. 2015

CDT

Self Cite

441

246

View full text Add to dashboard Cite

show abstract

“…RNA extraction was performed using the ALLPrep RNA Kit (QIAGEN), according to the manufacturer's instructions, and samples were quantified by absorption spectroscopy. Real‐time RT‐PCR was conducted as previously described [15].…”

Section: Methodsmentioning

confidence: 99%

Live‐cell single‐molecule imaging reveals clathrin and caveolin‐1 dependent docking of SMAD4 at the cell membrane

et al. 2013

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Transforming growth factor β (TGF-β) signaling is important for many biological processes. Although the sequential events of this cascade are known, the dynamics remain speculative. Here, live-cell single-molecule total internal reflection fluorescence microscopy was used to monitor the dynamics of SMAD4, a TGF-β downstream effector, in MDA-MB-231 breast cancer cells. Contrary to previous belief, SMAD4 was detectable at the cytoplasmic membrane, displaying two subpopulations with different membrane docking behaviors. These subpopulations were regulated by clathrin and caveolin-1, and had opposing roles in the nuclear shuttling of SMAD4 and the subsequent transcriptional regulation of genes associated with cell migration. The notion that membrane-docking behaviors of downstream molecules could predict the cellular response to growth factors may revolutionize the way we view cell signaling.

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“…In addition, the binding of CDK4 with p21Cip1 was boosted by hesperetin, showing their involvement in anti-cancer activity in MCF-7 cells. Hesperetin impaired the uptake of insulin-generated glucose and inhibited proliferation in MDA-MB-231 cancer cells 112 . This was followed by inhibition of insulin-related redistribution of GLUT4, phosphorylation of insulin receptor and AKT, finally causing antiproliferation of breast cancer cells.…”

Section: Hesperetinmentioning

confidence: 97%

An Insight into the Putative Role of Victuals Like Honey and its Polyphenols in Breast Cancer

et al. 2017

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Diet plays a crucial role in cancer advancement as well as prevention. Breast cancer is the second leading cause of cancer death among women. Recent research links breast cancer with diet and some evidence for the preventive effect of diet against breast cancer was also documented. The growth of cancer cells is influenced by natural sweetener honey and its multitude of phenolic phytochemical components. Honey has been used medicinally by ancient Greeks and Egyptians and also traditionally exploited in Ayurveda and Chinese medicine. In this paper, the anti-cancer properties of honey and its phytochemical's action against breast cancer have been summarized. They result in apoptosis by enhancing reactive oxygen species level, activating mitochondrial pathway, initiation of pro-apoptotic and anti-apoptotic proteins, induction of p53 pathway that finally cause DNA fragmentation. However, there is a necessity for more proteomic and genetic-based experiments to understand its molecular mechanism to promote honey and its phenolic markers as plausible candidates for breast cancer treatment. Further, there is a need for quality check of honey available in the market, which warrants significant investigation by researchers in the food industry to ensure their attributes.

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Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

Cited by 104 publications

References 46 publications

Safety of Nanoparticles in Medicine

Safety of Nanoparticles in Medicine

Live‐cell single‐molecule imaging reveals clathrin and caveolin‐1 dependent docking of SMAD4 at the cell membrane

An Insight into the Putative Role of Victuals Like Honey and its Polyphenols in Breast Cancer

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