2024
DOI: 10.1080/13510002.2024.2341470
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Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage

Jintao Lou,
Fan Wu,
Wuhui He
et al.

Abstract: Cisplatin is widely employed in clinical oncology as an anticancer chemotherapy drug in clinical practice and is known for its severe ototoxic side effects. Prior research indicates that the accumulation of reactive oxygen species (ROS) plays a pivotal role in cisplatin's inner ear toxicity. Hesperidin is a flavanone glycoside extracted from citrus fruits that has anti-inflammatory and antioxidant effects. Nonetheless, the specific pharmacological actions of hesperidin in alleviating cisplatin-induced ototoxic… Show more

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