Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats

Küçükler, Sefa; Caglayan, Cuneyt; Özdemir, Selçuk; Çomaklı, Selim; Kandemir, Fatih Mehmet

doi:10.1007/s11011-023-01339-8

Metab Brain Dis

2023

DOI: 10.1007/s11011-023-01339-8

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Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats

Sefa Küçükler,

Cuneyt Caglayan,

Selçuk Özdemir

et al.

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Cited by 3 publications

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Analytic and In Silico Methods to Understand the Interactions between Dinotefuran and Haemoglobin

Yadav,

Sewariya,

Singh

et al. 2024

Chemistry & Biodiversity

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This work lies in the growing concern over the potential impacts of pesticides on human health and the environment. Pesticides are extensively used to protect crops and control pests, but their interaction with essential biomolecules like haemoglobin remains poorly understood. Spectrofluorometric, electrochemical, and simulations investigations have been chosen as potential methods to delve into this issue, as they offer valuable insights into the molecular‐level interactions between pesticides and haemoglobin. The research aims to address the gaps in knowledge and contribute to the development of safer and more sustainable pesticide practices. The interaction was studied by spectroscopic techniques (UV‐Visible & Fluorescence), in silico studies (molecular docking & molecular dynamics simulations) and electrochemical techniques (cyclic voltammetry and tafel). The studies showed effective binding of dinotefuran with the Hb and will cause toxicity to human. The formation of a stable molecular complex between ofloxacin and hemoglobin was shown via molecular docking and the binding energy was found to ‐5.37 kcal/mol. Further, molecular dynamics simulations provide an insight for the stability of the complex (Hb‐dinotefuran) for a span of 250 ns with a binding free energy of ‐53.627 kJ/mol. Further, cyclic voltammetry and tafel studies for the interaction of dinotefuran with Hb effectively.

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Analytic and In Silico Methods to Understand the Interactions between Dinotefuran and Haemoglobin

Yadav,

Sewariya,

Singh

et al. 2024

Chemistry & Biodiversity

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Maternal exposure to pesticides induces perturbations in the gut microbiota and blood–brain barrier of dams and the progeny, prevented by a prebiotic

Abou Diwan,

Djekkoun,

Boucau

et al. 2024

Environ Sci Pollut Res

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Exposure to pesticide residues during the first 1000 days of life can disrupt body homeostasis and contribute to chronic metabolic diseases. Perinatal chlorpyrifos (CPF) exposure alters gut microbiota (GM) balance, potentially affecting offspring’s health. Given the GM influence on brain function, the primary aim is to determine if pesticide-induced dysbiosis (microbial imbalance) affects indirectly other organs, such as the blood–brain barrier (BBB). The secondary objective is to evaluate the prebiotics protective effects, particularly inulin in promoting microbial balance (symbiosis), in both mothers and offspring. A total of 15 or more female rats were divided in 4 groups: control, oral CPF-exposed (1 mg/kg/day), exposed to inulin (10 g/L), and co-exposed to CPF and inulin from pre-gestation until weaning of pups. Samples from intestines, spleen, liver, and brain microvessels underwent microbiological and biomolecular analyses. Bacterial culture assessed GM composition of living bacteria and their translocation to non-intestinal organs. RT qPCR and Western blotting detected gene expression and protein levels of tight junction markers in brain microvessels. CPF exposure caused gut dysbiosis in offspring, with decreased Lactobacillus and Bifidobacterium and increased Escherichia coli ( p < 0.01) leading to bacterial translocation to the spleen and liver. CPF also decreased tight junction’s gene expression levels (50 to 60% decrease of CLDN3, p < 0.05). In contrast, inulin partially mitigated these adverse effects and restored gene expression to control levels. Our findings demonstrate a causal link between GM alterations and BBB integrity disruptions. The protective effects of inulin suggest potential therapeutic strategies to counteract pesticide-induced dysbiosis.

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Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis

Akamo,

Ojelabi,

Somade

et al. 2025

Phytomedicine Plus

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Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats

Cited by 3 publications

References 57 publications

Analytic and In Silico Methods to Understand the Interactions between Dinotefuran and Haemoglobin

Analytic and In Silico Methods to Understand the Interactions between Dinotefuran and Haemoglobin

Maternal exposure to pesticides induces perturbations in the gut microbiota and blood–brain barrier of dams and the progeny, prevented by a prebiotic

Hesperidoside abolishes dichlorvos-mediated neurotoxicity in rats by suppressing oxidative stress, acetylcholinesterase inhibition, and NF-κB-p65/p53/caspase-3-mediated apoptosis

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