Hesperidin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th17 activity

Nagashio, Yuuki; Matsuura, Yuichirou; Miyamoto, Junpei; Kometani, Takashi; Suzuki, Takuya; Tanabe, Soichi

doi:10.1016/j.jff.2013.07.005

Cited by 24 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although prior studies have shown preventive benefit of hesperidin in allergic and irritant dermatitis model , in the present study, we did not observe any therapeutic effect of hesperidin in irritant dermatitis model. Moreover, our results from anti‐inflammatory study suggest that topical hesperidin does not attenuate anti‐inflammatory benefit of GC.…”

Section: Discussioncontrasting

confidence: 99%

Topical hesperidin prevents glucocorticoid‐induced abnormalities in epidermal barrier function in murine skin

Man

Mauro

Kim

et al. 2014

Experimental Dermatology

View full text Add to dashboard Cite

Systemic and topical glucocorticoids (GC) can cause significant adverse effects not only on the dermis, but also on epidermal structure and function. In epidermis, a striking GC-induced alteration in permeability barrier function occurs that can be attributed to an inhibition of epidermal mitogenesis, differentiation and lipid production. As prior studies in normal hairless mice demonstrated that topical applications of a flavonoid ingredient found in citrus, hesperidin, improve epidermal barrier function by stimulating epidermal proliferation and differentiation, we assessed here whether its topical applications could prevent GC-induced changes in epidermal function in murine skin and the basis for such effects. When hairless mice were co-treated topically with GC and 2% hesperidin twice-daily for 9 days, hesperidin co-applications prevented the expected GC-induced impairments of epidermal permeability barrier homoeostasis and stratum corneum (SC) acidification. These preventive effects could be attributed to a significant increase in filaggrin expression, enhanced epidermal β-glucocerebrosidase activity and accelerated lamellar bilayer maturation, the last two likely attributable to a hesperidin-induced reduction in stratum corneum pH. Furthermore, co-applications of hesperidin with GC largely prevented the expected GC-induced inhibition of epidermal proliferation. Finally, topical hesperidin increased epidermal glutathione reductase mRNA expression, which could counteract multiple functional negative effects of GC on epidermis. Together, these results show that topical hesperidin prevents GC-induced epidermal side effects by divergent mechanisms.

show abstract

Section: Discussioncontrasting

confidence: 99%

Topical hesperidin prevents glucocorticoid‐induced abnormalities in epidermal barrier function in murine skin

Man

Mauro

Kim

et al. 2014

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…All study protocols were preapproved by the Animal Use Committee of Hiroshima University (authorization No. C19- 19), and animal experiments were performed in accordance with Hiroshima University guidelines for the care and use of laboratory animals. Male 7-week old Balb/c mice were purchased from Charles River Japan (Yokohama, Japan).…”

Section: Animals and Dietsmentioning

confidence: 99%

“…Structurally, the LP consists of the outer layer, called flavedo, and the inner layer, called albedo; the flavedo contains high amounts of polyphenolic compounds, such as hesperidin, diosmin, eriocitrin, and narirutin [18], whereas the albedo is rich in fibers, particularly pectin. Hesperidin, one of the principal polyphenols in lemon, have been shown to possess various biological properties, such as anti-oxidant, anti-inflammatory, and anti-cancer effects [19][20][21]. Diosmin, eriocitrin, and narirutin are also reported to contribute to health care [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model

Tinh

Sitolo

Yamamoto

et al. 2021

Foods

Self Cite

View full text Add to dashboard Cite

This study examines the ameliorative effects of lemon (Citrus limon) peel (LP) powder on intestinal inflammation and barrier defects in dextran sulfate sodium (DSS)-induced colitic mice. The whole LP powder was fractionated into methanol (MetOH) extract and its extraction residue (MetOH residue), which were rich in polyphenolic compounds and dietary fibers, respectively. Mice were fed diets containing whole LP powder, MetOH extract, and MetOH residue for 16 d. DSS administration for 9 d induced bodyweight loss, reduced colon length, reduced the colonic expression of tight junction proteins including zonula occludens-1 and -2, and claudin-3 and -7, and upregulated colonic mRNA expression of interleukin 6, chemokine (C-X-C motif) ligand 2, and C-C motif chemokine ligand 2. Feeding LP powder restored these abnormalities, and the MetOH residue, but not MetOH extract, also showed similar restorations. Feeding LP powder and MetOH residue increased fecal concentrations of acetate and n-butyrate. Taken together, LP powder reduced intestinal damage through the protection of tight junction barriers and suppressed an inflammatory reaction in colitic mice. These results suggest that acetate and n-butyrate produced from the microbial metabolism of dietary fibers in LP powder contributed to reducing colitis.

show abstract

“…Previous studies have reported that these compounds exhibit therapeutic effects in both dermatological and neuropsychiatric diseases. In an earlier study, hesperidin alleviated the clinical severity of AD symptoms in the NC/Nga mouse model by modulating the T cell response [79]. A previous study also demonstrated the antiatopic effect of glycyrrhizic acid in DNCB-induced BALB/c mice by inhibiting mast cell activation [80].…”

Section: Discussionmentioning

confidence: 91%

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

Nguyen

Choi

Shin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Psychological stress is a major exacerbating factor of atopic dermatitis (AD), a chronic in ammatory skin disease. Sopoongsan (SPS), a traditional herbal formula, has been indicated for the treatment of various skin disorders, including AD. is study investigated the e ects of SPS on a 2,4-dinitrochlorobenzene-(DNCB-) induced AD mice model exposed to social isolation (SI) stress. e severity of the AD symptoms and behavioral abnormalities was evaluated. SPS reduced the clinical skin score as evaluated with the SCORing Atopic Dermatitis (SCORAD) index and suppressed the cutaneous in ltration of T-lymphocyte cells, mast cells, and eosinophils in SI-AD mice. e SPS treatment decreased the total distance and mean speed and increased resting time in the open eld test (OFT) for these mice. In addition, the time spent in the social zone in the social interaction test also improved when SPS treatment was given. e levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in the prefrontal cortex (PFC) in the SI-AD mice were reduced by the oral administration of SPS. HaCaT and BV2 cells were used for the in vitro experiments. e pretreatment with SPS reduced the protein levels of the thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in the HaCaT cells stimulated with TNF-α and interferon-gamma (IFN-c) (TI). SPS also suppressed TNF-α and IL-6 secretion in lipopolysaccharide-(LPS-) stimulated BV2 cells. ese results imply that SPS could be a promising candidate for the treatment of AD in patients under stress conditions and at risk of exacerbation.

show abstract

Hesperidin inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th17 activity

Cited by 24 publications

References 38 publications

Topical hesperidin prevents glucocorticoid‐induced abnormalities in epidermal barrier function in murine skin

Topical hesperidin prevents glucocorticoid‐induced abnormalities in epidermal barrier function in murine skin

Citrus limon Peel Powder Reduces Intestinal Barrier Defects and Inflammation in a Colitic Murine Experimental Model

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

Contact Info

Product

Resources

About