Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage

Martínez, Renata M.; Pinho‐Ribeiro, Felipe A.; Steffen, Vinicius S.; Caviglione, Carla V.; Vignoli, Josiane Alessandra; Baracat, Marcela M.; Georgetti, Sandra R.; Verri, Waldiceu A.; Casagrande, Rúbia

doi:10.1016/j.jphotobiol.2015.03.030

Cited by 45 publications

(53 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be attributed to the antioxidant properties of HSP against oxidative stress which is consistent with other studies that have reported protective role of HSP against oxidative stress [55][56][57][58][59]. HSP also inhibits oxidative stress and inflammation in ultraviolet B irradiation-induced skin damage in mice [60].…”

Section: Discussionsupporting

confidence: 90%

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

View full text Add to dashboard Cite

Zinc oxide nanoparticles (ZnONPs) are widely used in food packaging and may enter the body directly if exposed. Hereby, in this study, the oral administration was selected as the route of exposure for rats to nanoparticles and the effect of hesperidin (HSP, 100 mg/kg bwt) was evaluated on ZnONP (600 mg/kg bwt)-induced neurotoxicity in rats. ZnONPs were characterized using transmission electron microscopy. Neurotoxicity was observed as seen by elevation in serum inflammatory markers including tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), and activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) content in rat brains. Pretreatment of rats with HSP in ZnONP-treated group elevated activities of antioxidant enzymes. HSP also caused decrease in TNF-α, IL-1β, IL-6, and CRP levels which was higher in the ZnONP-treated group. The results suggest that HSP augments antioxidant defense with anti-inflammatory response against ZnONP-induced neurotoxicity. The increased antioxidant enzymes enhance the antioxidant potential to reduce oxidative stress.

show abstract

Section: Discussionsupporting

confidence: 90%

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…The anti-inflammatory and antioxidant potentials of hesperidin were also evident in the present investigation as well as in the earlier one [64] . It was claimed by many authors that such effects of hesperidin may be attributed show central arteriole (arrow head) and well-defined marginal zone (white arrow).…”

Section: Discussionsupporting

confidence: 90%

Protective Effects of Simvastatin and Hesperidin against Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rats

2015

View full text Add to dashboard Cite

Background/Aims: Rheumatoid arthritis (RA) is a disabling autoimmune disease for which most current treatments cause massive complications, thereby limiting treatment dose and duration. The anti-arthritic effects of the 3-hydroxy-3-metylglutary-CoA reductase inhibitor, simvastatin, and the natural flavonoid, hesperidin, were investigated against complete Freund's adjuvant-induced RA in rats. Methods: A normal control group, an arthritis control group, 2 reference treatment groups receiving dexamethasone (1.5 mg/kg/day) and methotrexate (1 mg/kg/day), and 2 treatment groups receiving simvastatin (0.5 mg/kg/day) and hesperidin (200 mg/kg/day) were included in the study. Serum rheumatoid factor, matrix metalloprotinease-3 (MMP-3) and cartilage oligomeric matrix protein (COMP) as specific rheumatoid biomarkers, serum immunoglobulin G (IgG) and antinuclear antibody (ANA) as immunological biomarkers, serum tumor necrosis factor-alpha and interleukin-10 as immunomodulatory cytokines, serum myeloperoxidase (MPO) and C-reactive protein as inflammatory biomarkers, and malondialdehyde (MDA) and glutathione (GSH) as oxidative stress biomarkers were assessed, supported by joint and spleen histopathological study. Results: Simvastatin significantly improved all the measured biomarkers, with MMP-3, COMP, and GSH restored to normal levels. Hesperidin significantly improved all the measured biomarkers, with COMP, IgG, ANA, MPO, MDA and GSH restored to normal levels. Conclusion: Simvastatin and hesperidin may be promising protective agents against RA through immunomodulatory, anti-inflammatory and antioxidant potentials.

show abstract

“…The UVB source was a Philips TL/12 RS 40W (Medical -Holland) with a peak emission at 313 nm. [12,14,17,27] The irradiation dose used to stimulate skin injury was 4.14 J/ cm 2 . [12,14,17,27] The UVB lamp was mounted 20 cm above the hairless mice with a radiation of 0.384 mW/cm 2 for 5.5 h (total of 4.14 J/cm 2 ).…”

Section: Irradiationmentioning

confidence: 99%

“…In this context, the utilization of anti‐inflammatory and antioxidant molecules can suppress interleukins and ROS production, thus preventing photoinactivation of antioxidant enzymes, LPO and induction of oxidative‐generated DNA damage after UVB irradiation exposure . UVB irradiation also triggers neutrophils and keratinocytes to produce matrix metalloproteinase‐9 (MMP‐9), which correlates with inflammatory skin diseases, accelerates photoageing and increases the metastatic potential of cancer cells . Therefore, strategies targeting the biological alterations induced by UVB irradiation in the skin are promising therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

“…[8,[11][12][13][14][15] UVB irradiation also triggers neutrophils and keratinocytes to produce matrix metalloproteinase-9 (MMP-9), which correlates with inflammatory skin diseases, accelerates photoageing and increases the metastatic potential of cancer cells. [16,17] Therefore, strategies targeting the biological alterations induced by UVB irradiation in the skin are promising therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin

Martínez

Ivan

Vale

et al. 2018

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage

Cited by 45 publications

References 63 publications

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Protective Effects of Simvastatin and Hesperidin against Complete Freund's Adjuvant-Induced Rheumatoid Arthritis in Rats

Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin

Contact Info

Product

Resources

About