Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation

Mahmoud, Ayman M.; Mohammed, Hanaa M.; Khadrawy, Sally M.; Galaly, Sanaa R.

doi:10.1016/j.cbi.2017.09.015

Cited by 113 publications

(67 citation statements)

References 83 publications

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“…In this context, Carica papaya leaf extract rich in phenolics and saponins showed anti-pancreatic cancer activity [29], and anthocyanins extracted from Zea mays exhibited antiproliferative activity against colon cancer cell lines [30]. Previous work from our lab has demonstrated the potent anti-carcinogenic effect of polyphenols as well as phenolics-rich extracts against HCC and colon carcinogenesis both in vivo and in vitro [31,32]. Here, HCC and lung cancer cell lines showed different sensitivity to each extract.…”

Section: Discussionmentioning

confidence: 86%

Metabolomic Profiling and Antioxidant, Anticancer and Antimicrobial Activities of Hyphaene thebaica

et al. 2020

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This study investigated the metabolic content and biological activities of Hyphaene thebaica leaves, male parts and fruits methanolic extracts. The phytochemical constituents were determined, and multivariate data analysis discriminated the evaluated three parts into three groups according to the content of phenolics, flavonoids, flavonols, saponins, anthocyanins and tannins. High-performance liquid chromatography (HPLC) profiling of polyphenols revealed the dominance of catechins, rutin and apigenin-7-glucosides in leaves, protocatechuin, p-hydroxybenzoic, syringic, vanillic, rosmarinic, p-coumaric acids and chrysin in male parts, and chlorogenic acid in fruits. Leaves and male parts showed stronger free radical scavenging activity than the fruits. Positive correlations between total antioxidant capacity and carbohydrates, phenolics and flavonols were observed. The three extracts exhibited potent anti-cancer activity against liver and lung carcinoma cell lines. All extracts exhibited antibacterial activity, while only fruits showed antifungal efficacy. In conclusion, H. thebaica leaves, male parts and fruits contain a variety of phytochemicals with antioxidant, anticancer and antimicrobial activities.

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Section: Discussionmentioning

confidence: 86%

Metabolomic Profiling and Antioxidant, Anticancer and Antimicrobial Activities of Hyphaene thebaica

et al. 2020

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“…[ 36 , 37 ]. Flavonoids have been reported to exert multiple effects such as antioxidant, anti-inflammatory, anticarcinogenic, antihyperlipidemic, hepatoprotective, and antidiabetic effects [ 38 – 40 ].…”

Section: Discussionmentioning

confidence: 99%

Monolluma quadrangula Protects against Oxidative Stress and Modulates LDL Receptor and Fatty Acid Synthase Gene Expression in Hypercholesterolemic Rats

Bin-Jumah

2018

Oxidative Medicine and Cellular Longevity

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Hypercholesterolemia is a metabolic disorder associated with oxidative stress. The present study investigated the protective effect of Monolluma quadrangula extract on hypercholesterolemia-induced oxidative stress in the liver and heart of high-cholesterol-diet- (HCD-) fed rats. The experimental animals received HCD for 10 weeks and were concurrently treated with 300 or 600 mg/kg M. quadrangula extract. HCD-fed rats showed a significant increase in serum triglycerides, total cholesterol, LDL-cholesterol, vLDL-cholesterol, and cardiovascular risk indices along with decreased HDL-cholesterol and antiatherogenic index. The M. quadrangula extract significantly improved dyslipidemia and atherogenesis in HCD-fed rats. HCD induced a significant increase in serum transaminases, creatine kinase-MB, and proinflammatory cytokines. In addition, HDC induced a significant increase in hepatic and cardiac lipid peroxidation and decreased antioxidant enzymes. Treatment with the M. quadrangula extract significantly alleviated liver and heart function markers, decreased proinflammatory cytokines and lipid peroxidation, and enhanced the antioxidant defenses. Also, the M. quadrangula extract significantly reduced the expression of fatty acid synthase (FAS) and increased the expression of LDL receptor in the liver of HCD-fed rats. In conclusion, the M. quadrangula extract has a potent antihyperlipidemic and cholesterol-lowering effect on HCD-fed rats. The beneficial effects of the M. quadrangula extract were mediated through the increased antioxidant defenses, decreased inflammation and lipid peroxidation, and modulated hepatic FAS and LDL receptor gene expression.

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“…These effects were mediated through the activation of Nrf2 following treatment with feruloyl oligosaccharides. Activation of Nrf2 has been reported to enhance the antioxidant defenses and protect against oxidative stress in drug-induced liver injury [103][104][105], endothelial dysfunction [106,107], hyperammonemia [108] and hepatocarcinogenesis [109,110]. Therefore, further studies are required to trace out the mechanisms underlying AXs-mediated activation of Nrf2.…”

Section: Antioxidant Capacity Of Axsmentioning

confidence: 99%

Health-related effects and improving extractability of cereal arabinoxylans

Fadel

Mahmoud

Ashworth

et al. 2018

International Journal of Biological Macromolecules

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Arabinoxylans (AXs) are major dietary fibers. They are composed of backbone chains of β-(1-4)-linked xylose residues to which α-l-arabinose are linked in the second and/or third carbon positions. Recently, AXs have attracted a great deal of attention because of their biological activities such as their immunomodulatory potential. Extraction of AXs has some difficulties; therefore, various methods have been used to increase the extractability of AXs with varying degrees of success, such as alkaline, enzymatic, mechanical extraction. However, some of these treatments have been reported to be either expensive, such as enzymatic treatments, or produce hazardous wastes and are non-environmentally friendly, such as alkaline treatments. On the other hand, mechanical assisted extraction, especially extrusion cooking, is an innovative pre-treatment that has been used to increase the solubility of AXs. The aim of the current review article is to point out the health-related effects and to discuss the current research on the extraction methods of AXs.

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Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation

Cited by 113 publications

References 83 publications

Metabolomic Profiling and Antioxidant, Anticancer and Antimicrobial Activities of Hyphaene thebaica

Metabolomic Profiling and Antioxidant, Anticancer and Antimicrobial Activities of Hyphaene thebaica

Monolluma quadrangula Protects against Oxidative Stress and Modulates LDL Receptor and Fatty Acid Synthase Gene Expression in Hypercholesterolemic Rats

Health-related effects and improving extractability of cereal arabinoxylans

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