Hesperidin suppresses the migration and invasion of non-small cell lung cancer cells by inhibiting the SDF-1/CXCR-4 pathway

Xia, Rongmu; Xu, Gang; Huang, Yanfang; Sheng, Xin; Xu, Xianlin; Lu, Haojie

doi:10.1016/j.lfs.2018.03.046

Cited by 62 publications

(41 citation statements)

References 37 publications

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“…Lung cancer is the most commonly diagnosed and reports high mortality, with 2.1 million new cases and 1.8 million deaths in 2018, accounting for 18.4% of cancer deaths (Bray et al, ). Lung cancer is composed of small cell lung cancer (SCLC) and non‐SCLC (NSCLC) according to histological characters, and NSCLC is responsible for up to 85% of the lung cancer (Xia et al, ). NSCLC is further divided into three subtypes adenocarcinoma (LAC), squamous cell carcinoma (SCC), and large cell carcinoma (LCC) (Oser et al, ).…”

Section: Introductionmentioning

confidence: 99%

TCF19 contributes to cell proliferation of non‐small cell lung cancer by inhibiting FOXO1

Zhou

Chen

Deng

et al. 2019

Cell Biology International

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Transcription factor 19 (TCF19) harbors a forkhead association (FHA) domain, a proline-rich region, a PHD or RING finger region, suggesting that TCF19 possesses a powerful function. However, its expression and function remains unknown in non-small-cell lung cancer (NSCLC). The function cluster analysis was carried out using Metascape website. 3-(4,5-Dimethyl-2-thiazolyl)2,5-diphenyl-2H-tetrazolium bromide (MTT), colony formation, and anchorage-independent growth ability assay were carried out to detect the effect of TCF19 on cell proliferation. Bromodeoxyuridine (Brdu) labeling and flow cytometry assay were used to evaluate the effect of TCF19 on cell-cycle progression. Quantitative polymerase chain reaction and chromatin immunoprecipitation assay were performed to investigate the mechanism by which TCF19 is involved in cell-cycle transition. By analyzing the publicly available dataset, The Cancer Genome Atlas (TCGA), we found that TCF19 is significantly increased in the lung adenocarcinoma (LAC) and squamous cell carcinoma (SCC), two primary histological subtype of NSCLC. Besides, further function cluster analysis exhibited that TCF19 may mainly participate in cell cycle. MTT, colony formation, and anchorage-independent growth ability assay confirmed that overexpression of TCF19 enhances the proliferation of both LAC and SCC cells. Besides, further experiments revealed that TCF19 contributes to cell cycle G1/S transition. Not only that, upregulation of TCF19 can inhibit the expression of p21, p27, and p57, while promote the expression of cyclin D1 by inhibiting FOXO1. Our research offers important evidence that TCF19 can promote cell-cycle progression of NSCLC cells, and TCF19 may served as novel therapeutic targets.

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Section: Introductionmentioning

confidence: 99%

TCF19 contributes to cell proliferation of non‐small cell lung cancer by inhibiting FOXO1

Zhou

Chen

Deng

et al. 2019

Cell Biology International

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“…In addition, naringin have antimetastatic activity in human prostate cancer DU145 cells (Erdogan, Doganlar, Doganlar, & Turkekul, 2018). Furthermore, it is reported that hesperidin has suppressive effect of cell mobility in nonsmall cell lung cancer A549 cells (Xia et al, 2018) and…”

Section: Discussionmentioning

confidence: 97%

“…In addition, naringin have antimetastatic activity in human prostate cancer DU145 cells (Erdogan, Doganlar, Doganlar, & Turkekul, ). Furthermore, it is reported that hesperidin has suppressive effect of cell mobility in nonsmall cell lung cancer A549 cells (Xia et al, ) and human osteosarcoma MG‐63 cells (Du et al, ). Yu et al also demonstrated that hesperin attenuated the epithelial to mesenchymal transition in A549 cells (Yu, Li, Ren, & Shen, ).…”

Section: Discussionmentioning

confidence: 99%

Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo

Choi

Lee

Hwangbo

et al. 2019

Phytotherapy Research

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The peel of Citrus unshiu Marcow. fruits (CU) has long been used as a traditional medicine that has therapeutic effects against pathogenic diseases, including asthma, vomiting, dyspepsia, blood circulation disorders, and various types of cancer. In this study, we investigated the effect of CU peel on metastatic melanoma, a highly aggressive skin cancer, in B16F10 melanoma cells, and in B16F10 cells inoculated‐C57BL/6 mice. Our results show that ethanol extracts of CU (EECU) inhibited cell growth and increased the apoptotic cells in B16F10 cells. EECU also stimulated the induction of mitochondria‐mediated intrinsic pathway, with reduced mitochondrial membrane potential and increased generation of intracellular reactive oxygen species. Furthermore, EECU suppressed the migration, invasion, and colony formation of B16F10 cells. In addition, the oral administration of EECU reduced serum lactate dehydrogenase activity without weight loss, hepatotoxicity, nor nephrotoxicity in B16F10 cell‐inoculated mice. Moreover, EECU markedly suppressed lung hypertrophy, the number and expression of metastatic tumor nodules, and the expression of inflammatory tumor necrosis factor‐alpha in lung tissue. In conclusion, our findings suggest that the inhibitory effect of EECU on the metastasis of melanoma indicates that it may be regarded as a potential therapeutic herbal drug for melanoma.

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“…chinese herbs and their natural extracts have exhibited beneficial anticancer properties by mediating the expression of epithelial-to-mesenchymal transition-associated markers and the expression of genes associated with drug resistance, apoptosis and cell cycle progression (30,31). Tangerine peel is a common chinese herbal medicine containing a variety of natural compounds, of which hesperidin and its derivative, hesperetin, have exhibited antitumor properties in vitro and in vivo (19,24,32,33). Hesperetin derived from the catabolism of hesperidin in the intestine has been widely used and investigated (34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

“…Hesperidin inhibits proliferation and induces apoptosis in lung cancer cells, without notable toxic effects on normal lung epithelial cells (18). Furthermore, hesperidin inhibits the migration and invasion of lung cancer cells by regulating the SdF1/cXcR4 axis (19). In vivo, hesperidin pretreatment protects against the development of carcinogen-induced lung cancer from multiple carcinogens (20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway

Kong¹,

Ling

Chen³

et al. 2020

Int J Mol Med

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Lung cancer is the leading cause of cancer-associated mortality worldwide. cisplatin (ddP) is a first-line chemotherapeutic drug for the treatment of lung cancer; however, the majority of patients develop resistance to ddP. P-glycoprotein (P-gp), also referred to as multidrug resistance (MdR) protein 1, is associated with an MdR phenotype, which results in failure of cancer chemotherapy; thus, identifying effective MdR pump inhibitors may improve the outcomes of patients who develop resistance to treatment. Hesperetin is a derivative of hesperidin, which is extracted from tangerine peel and exhibits multiple antitumor properties. In the present study, human lung adenocarcinoma A549 and A549/ddP cells were treated with different concentrations of hesperetin and DDP, respectively. Furthermore, rhodamine 123 efflux assays, cell counting Kit-8 assays, immunofluorescence, reverse transcription-quantitative PcR and western blot analysis were used to elucidate the mechanisms underlying the effects of hesperetin On A549/ddP cells. Additionally, a xenograft model of lung cancer in nude mice was established to explore the effects of hesperetin on A549/ddP cell growth in vivo. The results demonstrated that hesperetin sensitized A549/ddP cells to ddP. In vivo, hesperetin pretreatment significantly inhibited tumor growth. Mechanistically, hesperetin markedly decreased the expression of P-gp and increased the intracellular accumulation of the P-gp substrate, rhodamine 123, in A549/ddP cells. In addition, pretreatment of A549/ddP cells with hesperetin significantly inhibited nuclear factor (NF)-κB (p65) activity and its nuclear translocation. Taken together, the results of the present study suggest that hesperetin reversed P-gp-mediated MdR by decreasing P-gp expression in A549/ddP cells, which was associated with inhibition of the NF-κB signaling pathway. These findings may provide the basis for the use of hesperetin clinically to reverse MdR.

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Hesperidin suppresses the migration and invasion of non-small cell lung cancer cells by inhibiting the SDF-1/CXCR-4 pathway

Cited by 62 publications

References 37 publications

TCF19 contributes to cell proliferation of non‐small cell lung cancer by inhibiting FOXO1

TCF19 contributes to cell proliferation of non‐small cell lung cancer by inhibiting FOXO1

Citrus unshiu peel suppress the metastatic potential of murine melanoma B16F10 cells in vitro and in vivo

Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway

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