Heteroadamantanes and their derivatives. 23. Reduction of nitroaryl derivatives of 3,6-diazahomoadamantane

Synthesis of New Diazahomoadamantanone and Study the Reactivity of Carbonyl group

“…Its known diazahomoadamantanone and its derivatives have biological activity [9]. The present investigation describes the synthesis of new diazahomoadamantanone, containing a substituted aliphatic ring in the nodal positions [1][2][3][4][5][6]. We prepared 13,16-diazatetracyclo [9.…”

“…First one should realize how several simple molecules organize themselves into a larger one. It is well-known that by condensing a cyclic ketone with 1,3,6,8tetraazatricyclo [4.4.1.13,8]dode-cane (1) in 2propanol in the presence of acetic acid by Mannich,s reaction can give 3,6-diazahomoadamantan-9-one and its derivatives with substituents in the nodal positions [1][2][3][4][5][6].…”

“…6.1.11,13.111,16] eicosan-18-one) (2) (Scheme 1) by similar procedure applying the condensation of cyclic ketone (cyclododecanone) with compound (1). The reactivity of carbonyl group of (a cyclic ketone) diazahomoadamantanone with various chemical agents is common [1][2][3][4][5][6].…”