Heterobimetallic complexes of platinum(II) with diferrocenylphenylphosphine and theirin vitro activity against P388 leukaemia

Abstract

Four platinum(II) complexes of the general formula cis‐[Pt{(Ferr)2PhP}(DMSO)X2], where X2 = Cl2, C2O4, O2(CO)2(C6H11)2 and O2(CO)2CCH2CH2CH2, have been synthesized and­characterized physicochemically and spec‐­troscopically as the first heterobimetallic platinum(II) complexes with the ligand diferrocenylphenylphosphine (Ferr = ferrocenyl). These complexes were tested in vitro against leukaemia cell line P388 using the MTT assay. The results obtained were compared with those of cisplatin, carboplatin, oxaliplatin and 5‐fluorouracil. Copyright © 1999 John Wiley & Sons, Ltd.

Application of ferrocene and its derivatives in cancer research

“…Among them, complexes containing ferrocenyl groups were also studied. 105,110,111 Al-Allaf et al prepared a few Pt(II) complexes with the formula cis-[Pt(Fc 2 PhP)(DMSO)X 2 ] and tested their antitumor activity in vitro, against leukemia cell line P388. 110 Complexes 39 and 40 (Fig.…”

“…105,110,111 Al-Allaf et al prepared a few Pt(II) complexes with the formula cis-[Pt(Fc 2 PhP)(DMSO)X 2 ] and tested their antitumor activity in vitro, against leukemia cell line P388. 110 Complexes 39 and 40 (Fig. 16) showed IC50 values close to those of cisplatin and 5-fluorouracil.…”

Simple route to ferrocenylalkyl nucleobases. Antitumor activity in vivo

“…The activities were found for positively charged ferricenium salts,19, 20 uncharged ferrocene derivatives,20 potentially anionogenic Fc‐compounds21 and compounds with negative charge22 as well. The further development of these investigations included modification of ferrocene compounds by some cytostatic drugs and vitamins (sarcolysin,23 cisplatin,24 tamoxifen,5, 25 thiamin and hydroxythiamine26), as well as the synthesis of new original compounds. DNA is considered to be the more probable cellular target for ferrocene compounds 3.…”

Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands – Synthesis, Characterization, and Cytotoxicity

“…[4] Besides platinum-based metallodrugs, transitionmetal-based complexes, such as ferrocene-bearing compounds, have shown strong antiproliferative effects in vitro as well as antitumor effects in vivo. [9,[11][12][13] Some of these compounds have shown promising IC 50 values ( Figure 3): (i) Nieto et al recently published the successful synthesis and first cell culture tests of a cis-configured ferrocene-platinum derivative, which showed in vitro activity in human breast, cervix, lung and colon cancer cells in the low micromolar range (partially exceeding the antiproliferative activity of cisplatin); [11] (ii) a trans-dichloridoplatinum(II) complex featuring two ferrocene-bound phosphane units was designed by Schulz et al, which yielded low IC 50 values in the micromolar range in the ovarian cancer cell line A2780. In 1996, Jaouen et al coupled ferrocene to 4-hydroxytamoxifen and modified the length of the carbon chain in order to optimize its pharmacological properties ( Figure 2).…”