Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes: Synthesis, electrochemistry and antiplasmodial evaluation

Palladium (II) and platinum (II) complexes containing organometallic thiosemicarbazone ligands: Synthesis, characterization, X-ray structures and antitubercular evaluation

“…As expected in all cases, the 31 P-{ 1 H} NMR spectra exhibited a single resonance for the phosphorus nuclei, attesting to the purity of these complexes. According to literature reports, the absence of the resonance for the N-NH-C_S moiety (expected to occur at approximately 9.0 ppm) is further proof that the organometallic TSCs are coordinated under the anionic thiolate form [36][37][38].Suitable crystals of 2b and 3d were obtained by slowly diffusing hexane into dichloromethane. A full description of the crystal data, data collection and refinement parameters are given in the Supplementary material.…”

“…For the complexes (3a-d), the typical pattern of the ferrocenyl group was observed: a singlet at 4.0-4.2 ppm and two triplets at 4.4-5.1 ppm. These peaks were assigned to the C 5 H 5 and C 5 H 4 rings, respectively [36,38].It is important to note that the resonances of the imine groups (8.25-8.66 ppm) in the complexes 3a-d were shifted downfield compared with the signals of the corresponding organometallic TSC free ligand (Δδ = 0.8). This observation is in agreement with previously reports [36,38] and indicates the coordination of imine nitrogen atom to the metal centre.…”

“…We found that incorporating organometallic fragments into the thiosemicarbazone scaffold resulted in a complex that exhibited moderate activity against Trypanosoma cruzi and M. tuberculosis strains. In addition, Chibale and co-workers described the synthesis and antimalarial evaluation of palladium (II), ruthenium (II) and gold (III) complexes containing ferrocenyl thiosemicarbazones [38,40,41]. In all cases, the heterobimetallic complexes exhibited moderate activity against chloroquine-susceptible (NF54) and chloroquineresistant (Dd2) Plasmodium falciparum strains.…”

“…Transition metal complexes involving organic-TSCs have emerged as a new alternative to current therapeutic agents [32][33][34][35][36][37][38]. In this regard, we report the synthesis and biological evaluation of cyrhetrenyl and ferrocenyl thiosemicarbazones as potential trypanocidal and antitubercular agents [39].…”

“…For the complexes (3a-d), the typical pattern of the ferrocenyl group was observed: a singlet at 4.0-4.2 ppm and two triplets at 4.4-5.1 ppm. These peaks were assigned to the C 5 H 5 and C 5 H 4 rings, respectively [36,38].…”