Heterocoagulation of polysaccharide-coated platinum nanoparticles with ovarian-cancer cells

Estrela-Llopis, V. R.; Chevichalova, A. V.; Trigubova, N. A.; Ryzhuk, E. V.

doi:10.1134/s1061933x14050081

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…It was found that the endocytosis was the driving mechanism for the penetration of nanoparticles through the cellular membrane in cells. [159] Ali et al, biosynthesized PtNPs (30-45 nm size) using Iraqi Zahidi dates as reducing agent. PtNPs effectively was investigated against SKO-3 Ovarian cells.…”

Section: Ptnps In Ovarian Cancer Treatmentmentioning

confidence: 99%

Usage of Platinum Nanoparticles for Anticancer Therapy over Last Decade: A Review

Pawar

Sahoo

Verma

et al. 2021

Part & Part Syst Charact

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The quest for new functional nanomaterials is one of the defining purposes of nanoscience and nanotechnology. A large number of metal nanoparticles (NPs) are extensively exploited for biomedical applications. Metal NPs, in particular platinum NPs (PtNPs), possess remarkable properties that make them a potential candidate as a diagnostic or therapeutic agent. Due to potential technological interest over the last decade, PtNPs have attracted much attention in the field of anticancer research. PtNPs, when conjugated with many functionalizing agents such as polymers, ligands, drugs, peptides, and surfactants, exhibit improved targeting and reduced cytotoxic effects in various cancers. The PtNPs conjugated with folic acid, graphene oxide, and iron NPs are gained more attention due to their stability, large surface area, and reduced toxicity. To achieve this goal, PtNPs are co‐loaded with drugs or other modalities that offer an opportunity for multimodal activity in the frame of treating cancer types focusing on breast, blood, lung, ovarian, skin, liver, etc. However, a review of PtNPs’ function in diagnosis and treatment is still lacking. In this review, the effectiveness of PtNPs toward inducing and elevating death of the cancerous cells proving its delivery approaches and antitumor nature, concluding with future perspectives, are summarized.

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Section: Ptnps In Ovarian Cancer Treatmentmentioning

confidence: 99%

Usage of Platinum Nanoparticles for Anticancer Therapy over Last Decade: A Review

Pawar

Sahoo

Verma

et al. 2021

Part & Part Syst Charact

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“…The potent anticancer reagents of Ir-based compounds have triggered extensively interest as well [134,135]. In some studies, PGEbased nanomaterials have been explored as possible alternatives or associated with compounds for anticancer treatment [136][137][138][139][140][141]. However, researchers are developing more efficient treatments against tumors in consideration of the toxic effects of chemotherapies.…”

Section: Cancer Therapymentioning

confidence: 99%

Platinum group element-based nanozymes for biomedical applications: An overview

Yang

Lin

et al. 2020

Biomed. Mater.

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With a rapid advancement of nanotechnology and the close integration of disciplines, research on nanozymes (nanomaterials with enzyme-like activities), is becoming an expeditiously developing field. In recent years, platinum group element (PGE)-based (Pt, Pd, Ru, Rh, Ir, and Os) nanozymes developed successively, have not only promoted the research of nanozymes but also expanded the biomedical applications of nanomaterials. Generally speaking, PGE-based nanozymes process high catalytic efficiency, specific surface area, stability, and other physical/chemical properties, which benefit for their applications in biosensing, biological medicine, biomedical imaging, and environmental protection. This paper will introduce the research progress of PGE-based nanozymes including their synthesis, characterization, enzyme-like activities, stability, biocompatibility, toxicity, and applications for biological detection and clinical relevance. Our emphasis is put on unfolding the roles of PGE-based nanozymes in biomedical applications and how they overcome the limitations. Last but not least, trends and future perspectives of PGE-based nanozymes in biomedical applications are also provided.

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