“…7 On the other hand, there is a limited number of analogs where the stilbene core of CA-4 has been replaced with 1,3-substituted heterocycles. Examples of heterocyclic bridges include isoxazolines, 8 oxadiazolines, 9 and pyrazoles. 10 In our efforts to discover new potential anti-cancer CA-4 based chemotherapeutic agents, 11 we decided to explore series of 3,5-diaryl-4,5-dihydropyrazole compounds bearing a 3,4,5-trimethoxyphenyl moiety as the prerequisite for potent cytotoxicity, 6d combined with a variety of substituted phenyl rings, while the ethenyl bridge in the CA-4 skeleton was replaced with a structurally flexible non-aromatic nitrogen heterocycle which would augment biological solubility.…”