Heterocyclic Chemistry – A Mature Area in Its Infancy!

Abstract

For a long time, the construction of heterocycles reliably forged a carbonheteroatom bond by the interaction between a nucleophilic heteroatom and an electrophilic C=X or C–X‐moiety. This concept has been greatly expanded with the development of many synthetic methods that seemingly defy standard reactivities in molecules. The collection of almost 100 articles in the special issues of Eur. J. Org. Chem. and Asian Org. Chem. impressively attest to the creativity and efforts that are going on in this field: mature, but still young at heart.

Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)- quinazolinone derivatives

“…[ 4 , 5 ] Therefore, developing tailored chemotherapeutic drugs with minimal side effects and good selectivity is crucial for cancer treatment. Heterocyclic compounds are key synthetic targets for the creation of new chemotherapeutics with good selectivity and are being studied extensively as bioactive molecules [ [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] ]. Quinazolines are well-studied phenyl pyrimidine heterocycles with potential biological applications [ 16 , 17 ].…”

Brønsted Acid-Catalyzed Diastereoselective Synthesis of Spiroisoindolinones from Enamides

“…Nitrogen-containing heterocycles are of central importance in organic chemistry and constitute a prominent scaffold in natural products and active pharmaceutical ingredients . Among different heterocyclic scaffolds, spirocyclic compounds are attracting more attention in medicinal chemistry and drug discovery, particularly due to their intricate three-dimensional structures .…”