Heterocyclic Compounds Bearing Triazine Scaffold and Their Biological Significance: A Review

Abstract

Benzene is a six-membered hydrocarbon ring system and if three carbon-hydrogen units of benzene ring are replaced by nitrogen atoms then triazine is formed. Triazines are present in three isomeric forms 1,2,3- triazine, 1,2,4-triazine, and 1,3,5-triazine according to the position of the nitrogen atom. These are weak bases having weaker resonance energy than benzene, so nucleophilic substitution is preferred than electrophilic substitution. Triazine is an interesting class of heterocyclic compounds in medicinal chemistry. Numerous synthetic derivatives of triazine have been prepared and evaluated for a wide spectrum of biological activities in different models with desired findings such as antibacterial, antifungal, anti-cancer, antiviral, antimalarial, antiinflammatory, antiulcer, anticonvulsant, antimicrobial, insecticidal and herbicidal agents. Triazine analogs have exposed potent pharmacological activity. So, triazine nucleus may be considered as an interesting core moiety for researchers for the development of future drugs.

Formulation of a new broad‐spectrum UVB + UVA and blue light SPF50+ sunscreen containing Phenylene Bis‐Diphenyltriazine (TriAsorB), an innovative sun filter with unique optical properties

“…40 The filter has the empirical formula of C 36 H 24 N 6 and has a high molecular weight (540.61 g/mol). It is a heterocyclic compound and member of the 1,2,4-triazine family, 41 bearing a triazine scaffold in which three carbon-hydrogen units of the benzene ring are replaced by nitrogen atoms. It is therefore a chromophore for sunlight.…”

Phenylene Bis-Diphenyltriazine (TriAsorB), a new sunfilter protecting the skin against both UVB + UVA and blue light radiations

“…TriAsorB belongs to the 1,2,4-triazine family [43][44][45]. This chemical group has six membered rings bearing three nitrogens as shown in Fig.…”

“…Therefore, a new sunfilter from the 1,2,4-triazine family was recently described for improving performance and efficacy in solar protection. The members of the triazine family are heterocyclic compounds bearing triazine scaffold where three carbon-hydrogen units of benzene ring are replaced by nitrogen atoms [43][44][45]. The filter was 5,6,5′,6′-tetraphenyl-3,3′-(1,4-phenylene)bis [1,2, and was called TriAsorB (CAS N°55514-22-2).…”

Investigation on Photophysical, Solvatochromism and Biological Significance of Substituted 2H‐Indazole Derivatives

“…When compared to carbocyclic compounds, these heterocyclics contain additional heteroatoms like nitrogen, oxygen, Sulphur, etc. They also possess a wide spectrum of biological activities like antibacterial, antitumor, antifungal, antioxidant, antiviral, antimalarial and anthelmintic . Several reports on the anticancer activity of fused heterocyclic compounds with IC 50 values are available in the literature .…”