Heterocyclic compounds with potential biological activity coupled on poly(maleic anhydride-alt-vinyl acetate)

Şunel, Valeriu; Popa, Marcel; Dumitriu, Corina Lavinia; Ciobanu, A.; Bunia, I.; Popa, Aura Angelica

doi:10.1016/j.reactfunctpolym.2005.07.019

Cited by 17 publications

(12 citation statements)

References 16 publications

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“…Starting from the premise that the benzoxazole derivatives have important biological properties, our research was directed towards compounds V , VI , and VII immobilization by chemical binding (esterification) on the maleic anhydride‐ alt ‐vinyl acetate copolymer ( VIII ). Our purpose was obtaining a number of polymer‐active matter systems with a low level of toxicity, better and longer pharmacological effects because of the polymeric support, and a longer release as proven by other studies .…”

Section: Resultsmentioning

confidence: 99%

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Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride‐alt‐vinyl acetate)

Aparaschivei

Şunel

Popa

et al. 2014

Journal of Heterocyclic Chem

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New compounds with biological activity based on hydroxy‐amino derivatives of benzoxazolyl‐2‐mercaptoformic acid, benzoxazolyl‐2‐mercaptoacetic acid, and chloracetyl‐2‐mercaptobenzoxazole have been synthesized. The chemical bonding of these compounds to poly(maleic anhydride‐alt‐vinyl acetate), through esterification, leads in obtaining conjugates of polymer biologically active compound type, tests indicating a sustained release of the active chemical, with time (between 5 and 6 h). Reaction products were characterized through elemental and spectral analysis (FTIR and 1H NMR). Toxicology and antimicrobial activity tests recommend compounds with small molecule, as well as their conjugates as therapeutical candidates (antimicrobial inhibitors) for pharmacological application.

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Section: Resultsmentioning

confidence: 99%

“…It was synthesized by maleic anhydride copolymerization with vinyl acetate at 80°C in the presence of benzoyl peroxide . The copolymer was obtained as a white solid of 10,000 g mol −1 molecular weight.…”

Section: Methodsmentioning

confidence: 99%

Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride‐alt‐vinyl acetate)

Aparaschivei

Şunel

Popa

et al. 2014

Journal of Heterocyclic Chem

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“…The 1 H-NMR spectra of the resultant co-polymers spectra were recorded on a DPX-400 (400 MHz) spectrometer with DMSO-d 6 as solvent. The 13 C-NMR spectra of the resultant copolymers were recorded on a INOVA600 (600 MHz) spectrometer with DMSO-d 6 as solvent. IBVE/MA and HBVE/MA co-polymer solutions were uniformly prepared (10 wt%) in DMSO-d 6 .…”

Section: Co-polymer Characterizationmentioning

confidence: 99%

“…Through co-polymerization polymers with different structures and significant properties can be obtained. The difference on the microstructures of IBVE-MA (HBVE-MA) co-polymers greatly affects the properties of the obtained co-polymers [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Co-polymerization of Isobutyl/4-Hydroxybutyl Vinyl Ether and Maleic Anhydride

Wang

Tian

2010

Designed Monomers and Polymers

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A series of co-polymers of isobutyl vinyl ether (IBVE)/4-hydroxybutyl vinyl ether (HBVE) and maleic anhydride (MA) was synthesized and the structures were analysed using FT-IR, 1 H-NMR and 13 C-NMR. The results showed that the co-polymer of mono-functional vinyl ether (IBVE) and MA was completely alternating, but the co-polymer of dual-functional vinyl ether (HBVE) and MA was quite different, and this co-polymer usually exists as a gel. The influence of feed ratio of monomers, initiator concentration and reaction temperature on the co-polymerization was also studied. Novel complex materials (IBVE-MA/PVA) were obtained. The results showed that IBVE-MA could markedly improve flexibility of poly(vinyl alcohol) (PVA); the elongation of the PVA could improve to 300% after addition of 2% IBVE-MA from 30% of pure PVA.

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“…Among the various methods for the synthesis of pyrazoles 2 + 3 or 3 + 2 principle of an olefin with diazomethane ylide or hydrazine hydrate is an important and versatile one. In addition, substituted benzoxazoles display antimicrobial , antitumor, anti‐tubercular, anti‐inflammatory, and HIV‐1 reverse transcriptase inhibitory activities . On the other hand, benzothiazole is an important constituent in various marine and terrestrial natural products .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of a New Class of Benzazolyl Pyrazoles

Durgamma

Thatha

Padmavathi

et al. 2017

Journal of Heterocyclic Chem

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A new class of benzazolyl pyrazoles were prepared from the simple substrates benzoxazol‐2‐thiol, benzothiazol‐2‐thiol, 1H‐benzimidazol‐2‐thiol and cinnamoyl chloride and tested for antimicrobial activity. The compounds 2‐(benzothiazol‐2‐ylthio)‐1‐(3‐(benzothiazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl)ethanone and 2‐(benzothiazol‐2‐ylamino)‐1‐(3‐(benzothiazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl)ethanone showed pronounced antibacterial activity against Klebsiella pneumoniae whereas 2‐(1H‐benzimidazol‐2‐ylthio)‐1‐(3‐(1H‐benzimidazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl)ethanone and 2‐(1H‐benzimidazol‐2‐ylamino)‐1‐(3‐(1H‐benzimidazol‐2‐ylthio)‐5‐phenyl‐1H‐pyrazol‐1‐yl) ethanone displayed excellent antifungal activity against Penicillium chrysogenum.

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Heterocyclic compounds with potential biological activity coupled on poly(maleic anhydride-alt-vinyl acetate)

Cited by 17 publications

References 16 publications

Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride‐alt‐vinyl acetate)

Conjugates with an Antimicrobial Effect Based on New Derivatives of Mercaptobenzoxazole Esterified onto Poly(maleic anhydride‐alt‐vinyl acetate)

Co-polymerization of Isobutyl/4-Hydroxybutyl Vinyl Ether and Maleic Anhydride

Synthesis and Antimicrobial Activity of a New Class of Benzazolyl Pyrazoles

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