Heterocyclic Ketene Aminals

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research 2964 spotlight Heterocyclic Ketene Aminals Compiled by Li-Fen YangLi-Fen Yang was born in Yunnan, P. R. of China. She received her B.Sc. in chemistry from Yunnan Normal University in 2011. Currently she is a second-year postgraduate student with Professor Sheng-Jiao Yan and Professor Jun Lin at Yunnan University. Her research is focused on the development of new synthetic methodologies and on the synthesis of heterocycles.

Diastereoselective Synthesis of Morphan Derivatives by Michael and Hetero-Michael Addition of 1,1-Enediamines to Quinone Monoketals

“…Cyclic 1,1-enediamines (EDAMs) are a fascinating and versatile building block that is widely used to synthesize various fused heterocyclic compounds including quinolones, isoquinolin-1-imines, indoles, indolin-2-ones, isocoumarins, pyridines, and pyrroles . Many of these compounds have a wide range of biological activities, such as antitumor, herbicide, pesticide, antianxiety, antileishmanial, and antibacterial .…”

A Convenient Synthesis of 3,7′-Bisindole Derivatives

“…Heterocyclic ketene aminals (HKAs) are versatile building blocks used to construct a variety of fused heterocyclic compounds [31,32,33], such as quinolones [34,35], pyridines [36,37,38,39,40,41,42], pyrroles [43,44,45,46,47], spirooxindoles [48,49], etc. In recent years, we have developed some protocols to synthesize different substituted indole derivatives based on HKA building blocks [50,51,52] (Figure 2).…”

Synthesis of Pyrimidopyrrolopyridazines via a Tandem Reaction of Heterocyclic Ketene Aminals with 1,2-Diaza-1,3-dienes

“…Heterocyclic ketene aminals (HKAs, Figure ) possess an electron-rich carbon that can serve as a nucleophile, and 1,2-diaza-1,3-dienes (DDs, Figure ) can be viewed as hydrazide precursors with electrophilic properties . These two classes of building blocks have found use in the construction of various heterocyclic systems .…”